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Q338B9

- GCN5_ORYSJ

UniProt

Q338B9 - GCN5_ORYSJ

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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acetylates histone H3. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators. Acts via the formation of large multiprotein complexes that modify the chromatin By similarity.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei233 – 2331Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. DNA binding Source: EnsemblPlants/Gramene
  2. H3 histone acetyltransferase activity Source: EnsemblPlants/Gramene

GO - Biological processi

  1. cullin deneddylation Source: EnsemblPlants/Gramene
  2. flower development Source: EnsemblPlants/Gramene
  3. histone methylation Source: EnsemblPlants/Gramene
  4. photomorphogenesis Source: EnsemblPlants/Gramene
  5. positive regulation of transcription, DNA-templated Source: EnsemblPlants/Gramene
  6. post-translational protein modification Source: EnsemblPlants/Gramene
  7. protein deubiquitination Source: EnsemblPlants/Gramene
  8. protein ubiquitination Source: EnsemblPlants/Gramene
  9. response to xenobiotic stimulus Source: EnsemblPlants/Gramene
  10. root morphogenesis Source: EnsemblPlants/Gramene
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:Os10g0415900, LOC_Os10g28040
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 10

Organism-specific databases

GrameneiQ338B9.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. histone acetyltransferase complex Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Histone acetyltransferase GCN5PRO_0000269749Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ338B9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os10g28040.1.

Structurei

3D structure databases

ProteinModelPortaliQ338B9.
SMRiQ338B9. Positions 160-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 315148N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST
Domaini415 – 48672BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2393Acetyl-CoA bindingBy similarity
Regioni244 – 2507Acetyl-CoA bindingBy similarity
Regioni276 – 2794Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 6760Ser-richAdd
BLAST
Compositional biasi68 – 736Poly-Asp
Compositional biasi104 – 12421Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
InParanoidiQ338B9.
KOiK06062.
OMAiMVIRNNI.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q338B9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGLAAPSPS HSGATSGGGA SHRKRKLPPS SLSDATADED DDTTAPSSPS
60 70 80 90 100
TSPSSPSRPS SPSSSHSDDD DDDSLHTFTA ARLDGAPPSS SGRPPKPESS
110 120 130 140 150
TVSAAAAAAA AAAAPKPDSA SAAAGDGKED PKGLFTDNIQ TSGAYSAREE
160 170 180 190 200
GLKREEEAGR LKFLCYSNDG VDEHMIWLVG LKNIFARQLP NMPKEYIVRL
210 220 230 240 250
VMDRTHKSMM VIRNNIVVGG ITYRPYTSQK FGEIAFCAIT ADEQVKGYGT
260 270 280 290 300
RLMNHLKQHA RDADGLTHFL TYADNNAVGY FVKQGFTKEI TLDKERWQGY
310 320 330 340 350
IKDYDGGILM ECRIDQKLPY VDLATMIRRQ RQAIDEKIRE LSNCHIVYSG
360 370 380 390 400
IDFQKKEAGI PRRTMKPEDI QGLREAGWTP DQWGHSKSRS AFSPDYSTYR
410 420 430 440 450
QQLTNLMRSL LKNMNEHPDA WPFKEPVDSR DVPDYYDIIK DPIDLKTMSK
460 470 480 490 500
RVESEQYYVT LEMFVADMKR MFSNAKTYNS PDTIYYKCAS RLESFFSNKV
510
ASQLAQASTK N
Length:511
Mass (Da):56,685
Last modified:December 6, 2005 - v1
Checksum:iA506C27F8D96D673
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000086 Genomic DNA. Translation: ABB47615.1.
AP008216 Genomic DNA. Translation: BAF26518.1.
AK111779 mRNA. No translation available.
RefSeqiNP_001064604.1. NM_001071139.1.
UniGeneiOs.21782.

Genome annotation databases

EnsemblPlantsiOS10T0415900-01; OS10T0415900-01; OS10G0415900.
GeneIDi4348629.
KEGGiosa:4348629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000086 Genomic DNA. Translation: ABB47615.1 .
AP008216 Genomic DNA. Translation: BAF26518.1 .
AK111779 mRNA. No translation available.
RefSeqi NP_001064604.1. NM_001071139.1.
UniGenei Os.21782.

3D structure databases

ProteinModelPortali Q338B9.
SMRi Q338B9. Positions 160-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os10g28040.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS10T0415900-01 ; OS10T0415900-01 ; OS10G0415900 .
GeneIDi 4348629.
KEGGi osa:4348629.

Organism-specific databases

Gramenei Q338B9.

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000192257.
InParanoidi Q338B9.
KOi K06062.
OMAi MVIRNNI.

Gene expression databases

ExpressionAtlasi Q338B9. baseline.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
    Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
    , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
    Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiGCN5_ORYSJ
AccessioniPrimary (citable) accession number: Q338B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3