Reviewed, UniProtKB/Swiss-Prot Q338B9 (GCN5_ORYSJ)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase GCN5
    EC=2.3.1.48

Gene names

Name:	GCN5
Ordered Locus Names:	Os10g0415900, LOC_Os10g28040

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acetylates histone H3. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators. Acts via the formation of large multiprotein complexes that modify the chromatin By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Bromodomain
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Histone acetyltransferase GCN5		PRO_0000269749
Regions
	Domain	168 – 315	148	N-acetyltransferase
	Domain	415 – 486	72	Bromo
	Compositional bias	8 – 67	60	Ser-rich
	Compositional bias	68 – 73	6	Poly-Asp
	Compositional bias	104 – 124	21	Ala-rich

Sequences

	Sequence		Length	Mass (Da)
	Q338B9-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: A506C27F8D96D673	FASTA	511	56,685
	10 20 30 40 50 60 MDGLAAPSPS HSGATSGGGA SHRKRKLPPS SLSDATADED DDTTAPSSPS TSPSSPSRPS 70 80 90 100 110 120 SPSSSHSDDD DDDSLHTFTA ARLDGAPPSS SGRPPKPESS TVSAAAAAAA AAAAPKPDSA 130 140 150 160 170 180 SAAAGDGKED PKGLFTDNIQ TSGAYSAREE GLKREEEAGR LKFLCYSNDG VDEHMIWLVG 190 200 210 220 230 240 LKNIFARQLP NMPKEYIVRL VMDRTHKSMM VIRNNIVVGG ITYRPYTSQK FGEIAFCAIT 250 260 270 280 290 300 ADEQVKGYGT RLMNHLKQHA RDADGLTHFL TYADNNAVGY FVKQGFTKEI TLDKERWQGY 310 320 330 340 350 360 IKDYDGGILM ECRIDQKLPY VDLATMIRRQ RQAIDEKIRE LSNCHIVYSG IDFQKKEAGI 370 380 390 400 410 420 PRRTMKPEDI QGLREAGWTP DQWGHSKSRS AFSPDYSTYR QQLTNLMRSL LKNMNEHPDA 430 440 450 460 470 480 WPFKEPVDSR DVPDYYDIIK DPIDLKTMSK RVESEQYYVT LEMFVADMKR MFSNAKTYNS 490 500 510 PDTIYYKCAS RLESFFSNKV ASQLAQASTK N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"In-depth view of structure, activity, and evolution of rice chromosome 10." Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H. , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A. Science 300:1566-1569(2003) [PubMed: 12791992] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DP000086 Genomic DNA. Translation: ABB47615.1. AP008216 Genomic DNA. Translation: BAF26518.1. AK111779 mRNA. No translation available.
RefSeq	NP_001064604.1.
UniGene	Os.21782
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4348629.
GenomeReviews	Gene locus GCN5 in contig AP008216_GR.
KEGG	osa:4348629.
Organism-specific databases
Gramene	Q338B9.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR000182. GCN5-rel_AcTrfase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.20.920.10. Bromodomain. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 1 hit. [Graphical view]
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCN5_ORYSJ

Accession

Primary (citable) accession number: Q338B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 6, 2005
Last modified:	September 22, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)