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Protein

Cytochrome c oxidase subunit 3

Gene

COIII

Organism
Patiria pectinifera (Starfish) (Asterina pectinifera)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COIII
Encoded oniMitochondrion
OrganismiPatiria pectinifera (Starfish) (Asterina pectinifera)
Taxonomic identifieri7594 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaAsterozoaAsteroideaValvataceaValvatidaAsterinidaePatiria

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 3PRO_0000183743Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ33824.
SMRiQ33824. Positions 1-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q33824-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQHPYHLV DQSPWPLTGA ISALMMTSGL ILWFHTNSNH LLLAGTILLL
60 70 80 90 100
LTVINWWRDV IREATFQGSH TLPVNTGLRY GMILFITSEV CFFFAFFWAF
110 120 130 140 150
FHSSLAPTVE LGVSWPPTGI SPINPFLVPL LNTAVLLSSG VTVTWAHHSI
160 170 180 190 200
LTQNRTEAIQ GLFLTVILGI YFTGLQAWEY YDSPFTIADS VYGSSFFVAT
210 220 230 240 250
GFHGLHVLIG TTFLFICFLR LITFHFSNNH HFGFEAAAWY WHFVDVVWLF
260
LYICICWWGS
Length:260
Mass (Da):29,587
Last modified:May 30, 2000 - v2
Checksum:iEF72F6E603E4053B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16387 Genomic DNA. Translation: BAA03885.2.
M17619 Genomic DNA. Translation: AAA65514.2.
PIRiS70589.
RefSeqiNP_008160.1. NC_001627.1.

Genome annotation databases

GeneIDi807818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16387 Genomic DNA. Translation: BAA03885.2.
M17619 Genomic DNA. Translation: AAA65514.2.
PIRiS70589.
RefSeqiNP_008160.1. NC_001627.1.

3D structure databases

ProteinModelPortaliQ33824.
SMRiQ33824. Positions 1-260.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi807818.

Organism-specific databases

CTDi4514.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence and gene organization of the starfish Asterina pectinifera mitochondrial genome."
    Asakawa S., Himeno H., Miura K., Watanabe K.
    Genetics 140:1047-1060(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Ovary.
  2. "Unusual genetic codes and a novel gene structure for tRNA(AGYSer) in starfish mitochondrial DNA."
    Himeno H., Masaki H., Kawai T., Ohta T., Kumagai I., Miura K., Watanabe K.
    Gene 56:219-230(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 193-260.

Entry informationi

Entry nameiCOX3_PATPE
AccessioniPrimary (citable) accession number: Q33824
Secondary accession number(s): P11958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: January 7, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.