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Protein

Cytochrome c oxidase subunit 3

Gene

COIII

Organism
Patiria pectinifera (Starfish) (Asterina pectinifera)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COIII
Encoded oniMitochondrion
OrganismiPatiria pectinifera (Starfish) (Asterina pectinifera)
Taxonomic identifieri7594 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaAsterozoaAsteroideaValvataceaValvatidaAsterinidaePatiria

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837431 – 260Cytochrome c oxidase subunit 3Add BLAST260

Structurei

3D structure databases

ProteinModelPortaliQ33824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q33824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQHPYHLV DQSPWPLTGA ISALMMTSGL ILWFHTNSNH LLLAGTILLL
60 70 80 90 100
LTVINWWRDV IREATFQGSH TLPVNTGLRY GMILFITSEV CFFFAFFWAF
110 120 130 140 150
FHSSLAPTVE LGVSWPPTGI SPINPFLVPL LNTAVLLSSG VTVTWAHHSI
160 170 180 190 200
LTQNRTEAIQ GLFLTVILGI YFTGLQAWEY YDSPFTIADS VYGSSFFVAT
210 220 230 240 250
GFHGLHVLIG TTFLFICFLR LITFHFSNNH HFGFEAAAWY WHFVDVVWLF
260
LYICICWWGS
Length:260
Mass (Da):29,587
Last modified:May 30, 2000 - v2
Checksum:iEF72F6E603E4053B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16387 Genomic DNA. Translation: BAA03885.2.
M17619 Genomic DNA. Translation: AAA65514.2.
PIRiS70589.
RefSeqiNP_008160.1. NC_001627.1.

Genome annotation databases

GeneIDi807818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16387 Genomic DNA. Translation: BAA03885.2.
M17619 Genomic DNA. Translation: AAA65514.2.
PIRiS70589.
RefSeqiNP_008160.1. NC_001627.1.

3D structure databases

ProteinModelPortaliQ33824.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi807818.

Organism-specific databases

CTDi4514.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_PATPE
AccessioniPrimary (citable) accession number: Q33824
Secondary accession number(s): P11958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.