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Q336X9

- MPK6_ORYSJ

UniProt

Q336X9 - MPK6_ORYSJ

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Protein

Mitogen-activated protein kinase 6

Gene

MPK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPPROSITE-ProRule annotation
Active sitei169 – 1691Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_203586. ERK/MAPK targets.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.
REACT_224658. Regulation of HSF1-mediated heat shock response.
REACT_233484. Signal transduction by L1.
REACT_248492. ISG15 antiviral mechanism.
REACT_261734. Signaling by FGFR.
REACT_268490. Signalling to ERK5.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 6 (EC:2.7.11.24)
Short name:
MAP kinase 6
Gene namesi
Name:MPK6
Ordered Locus Names:Os10g0533600, LOC_Os10g38950
ORF Names:OSJNBa0053C23.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 10

Organism-specific databases

GrameneiQ336X9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Mitogen-activated protein kinase 6PRO_0000239749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011PhosphothreonineBy similarity
Modified residuei203 – 2031PhosphotyrosineCurated

Post-translational modificationi

Dually phosphorylated on Thr-201 and Tyr-203, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ336X9.

Expressioni

Gene expression databases

ExpressionAtlasiQ336X9. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ336X9. 1 interaction.
MINTiMINT-7234445.

Structurei

3D structure databases

ProteinModelPortaliQ336X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 329287Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi201 – 2033TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ336X9.
KOiK04371.
OMAiHENIISV.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q336X9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSSSGGAGG GGGAQIKGMG THGGRYVLYN VYGNFFEVSS KYAPPIRPIG
60 70 80 90 100
RGAYGIVCAA VNSENGEEVA IKKIGNAFDN HIDAKRTLRE IKLLRHMDHE
110 120 130 140 150
NIIAIKDIIR PPRRDNFNDV YIVSELMDTD LHQIIRSNQP LTDDHCQYFL
160 170 180 190 200
YQLLRGLKYV HSANVLHRDL KPSNLFLNAN CDLKIADFGL ARTTTETDLM
210 220 230 240 250
TEYVVTRWYR APELLLNCSQ YTAAIDVWSV GCILGEIVTR QPLFPGRDYI
260 270 280 290 300
QQLKLITELI GSPDDSSLGF LRSDNARRYM KQLPQYPRQD FRLRFRNMSA
310 320 330 340 350
GAVDLLEKML VFDPSRRITV DEALHHPYLA SLHDINEEPT CPAPFSFDFE
360 370
QPSFTEEHIK ELIWRESLAF NPDPPY
Length:376
Mass (Da):42,773
Last modified:December 6, 2005 - v1
Checksum:i700EC7AAEE91AA45
GO

Sequence cautioni

The sequence AAM88622.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AK111579 differs from that shown. Reason: Frameshift at position 359. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092389 Genomic DNA. Translation: AAM88622.1. Sequence problems.
DP000086 Genomic DNA. Translation: ABB47925.1.
AP008216 Genomic DNA. Translation: BAF27070.1.
AK111579 mRNA. No translation available.
RefSeqiNP_001065156.1. NM_001071691.1.
UniGeneiOs.15044.

Genome annotation databases

EnsemblPlantsiOS10T0533600-01; OS10T0533600-01; OS10G0533600.
GeneIDi4349225.
KEGGiosa:4349225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092389 Genomic DNA. Translation: AAM88622.1 . Sequence problems.
DP000086 Genomic DNA. Translation: ABB47925.1 .
AP008216 Genomic DNA. Translation: BAF27070.1 .
AK111579 mRNA. No translation available.
RefSeqi NP_001065156.1. NM_001071691.1.
UniGenei Os.15044.

3D structure databases

ProteinModelPortali Q336X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q336X9. 1 interaction.
MINTi MINT-7234445.

Proteomic databases

PRIDEi Q336X9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS10T0533600-01 ; OS10T0533600-01 ; OS10G0533600 .
GeneIDi 4349225.
KEGGi osa:4349225.

Organism-specific databases

Gramenei Q336X9.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q336X9.
KOi K04371.
OMAi HENIISV.

Enzyme and pathway databases

Reactomei REACT_203586. ERK/MAPK targets.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.
REACT_224658. Regulation of HSF1-mediated heat shock response.
REACT_233484. Signal transduction by L1.
REACT_248492. ISG15 antiviral mechanism.
REACT_261734. Signaling by FGFR.
REACT_268490. Signalling to ERK5.

Gene expression databases

ExpressionAtlasi Q336X9. baseline.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
    Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
    , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
    Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  5. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMPK6_ORYSJ
AccessioniPrimary (citable) accession number: Q336X9
Secondary accession number(s): Q0IW45, Q8LN33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3