Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q336X9 (MPK6_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 6

Short name=MAP kinase 6
EC=2.7.11.24
Gene names
Name:MPK6
Ordered Locus Names:Os10g0533600, LOC_Os10g38950
ORF Names:OSJNBa0053C23.4
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-201 and Tyr-203, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAM88622.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AK111579 differs from that shown. Reason: Frameshift at position 359.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Mitogen-activated protein kinase 6
PRO_0000239749

Regions

Domain43 – 329287Protein kinase
Nucleotide binding49 – 579ATP By similarity
Motif201 – 2033TXY

Sites

Active site1691Proton acceptor By similarity
Binding site721ATP By similarity

Amino acid modifications

Modified residue2011Phosphothreonine By similarity
Modified residue2031Phosphotyrosine Probable

Sequences

Sequence LengthMass (Da)Tools
Q336X9 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 700EC7AAEE91AA45

FASTA37642,773
        10         20         30         40         50         60 
MDSSSGGAGG GGGAQIKGMG THGGRYVLYN VYGNFFEVSS KYAPPIRPIG RGAYGIVCAA 

        70         80         90        100        110        120 
VNSENGEEVA IKKIGNAFDN HIDAKRTLRE IKLLRHMDHE NIIAIKDIIR PPRRDNFNDV 

       130        140        150        160        170        180 
YIVSELMDTD LHQIIRSNQP LTDDHCQYFL YQLLRGLKYV HSANVLHRDL KPSNLFLNAN 

       190        200        210        220        230        240 
CDLKIADFGL ARTTTETDLM TEYVVTRWYR APELLLNCSQ YTAAIDVWSV GCILGEIVTR 

       250        260        270        280        290        300 
QPLFPGRDYI QQLKLITELI GSPDDSSLGF LRSDNARRYM KQLPQYPRQD FRLRFRNMSA 

       310        320        330        340        350        360 
GAVDLLEKML VFDPSRRITV DEALHHPYLA SLHDINEEPT CPAPFSFDFE QPSFTEEHIK 

       370 
ELIWRESLAF NPDPPY 

« Hide

References

« Hide 'large scale' references
[1]"In-depth view of structure, activity, and evolution of rice chromosome 10."
Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H. expand/collapse author list , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.
[5]"Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
Reyna N.S., Yang Y.
Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC092389 Genomic DNA. Translation: AAM88622.1. Sequence problems.
DP000086 Genomic DNA. Translation: ABB47925.1.
AP008216 Genomic DNA. Translation: BAF27070.1.
AK111579 mRNA. No translation available.
RefSeqNP_001065156.1. NM_001071691.1.
UniGeneOs.15044.

3D structure databases

ProteinModelPortalQ336X9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ336X9. 1 interaction.
MINTMINT-7234445.

Proteomic databases

PRIDEQ336X9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS10T0533600-01; OS10T0533600-01; OS10G0533600.
GeneID4349225.
KEGGosa:4349225.

Organism-specific databases

GrameneQ336X9.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK04371.
OMATIDEFHA.
ProtClustDBCLSN2698224.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPK6_ORYSJ
AccessionPrimary (citable) accession number: Q336X9
Secondary accession number(s): Q0IW45, Q8LN33
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations