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Q336X9

- MPK6_ORYSJ

UniProt

Q336X9 - MPK6_ORYSJ

Protein

Mitogen-activated protein kinase 6

Gene

MPK6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPPROSITE-ProRule annotation
    Active sitei169 – 1691Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205014. CREB phosphorylation through the activation of Ras.
    REACT_214549. Signalling to ERK5.
    REACT_215626. ERK2 activation.
    REACT_221522. ERKs are inactivated.
    REACT_221537. ERK1 activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 6 (EC:2.7.11.24)
    Short name:
    MAP kinase 6
    Gene namesi
    Name:MPK6
    Ordered Locus Names:Os10g0533600, LOC_Os10g38950
    ORF Names:OSJNBa0053C23.4
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 10

    Organism-specific databases

    GrameneiQ336X9.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Mitogen-activated protein kinase 6PRO_0000239749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei201 – 2011PhosphothreonineBy similarity
    Modified residuei203 – 2031PhosphotyrosineCurated

    Post-translational modificationi

    Dually phosphorylated on Thr-201 and Tyr-203, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ336X9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ336X9. 1 interaction.
    MINTiMINT-7234445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ336X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 329287Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi201 – 2033TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK04371.
    OMAiHENIISV.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q336X9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSSGGAGG GGGAQIKGMG THGGRYVLYN VYGNFFEVSS KYAPPIRPIG    50
    RGAYGIVCAA VNSENGEEVA IKKIGNAFDN HIDAKRTLRE IKLLRHMDHE 100
    NIIAIKDIIR PPRRDNFNDV YIVSELMDTD LHQIIRSNQP LTDDHCQYFL 150
    YQLLRGLKYV HSANVLHRDL KPSNLFLNAN CDLKIADFGL ARTTTETDLM 200
    TEYVVTRWYR APELLLNCSQ YTAAIDVWSV GCILGEIVTR QPLFPGRDYI 250
    QQLKLITELI GSPDDSSLGF LRSDNARRYM KQLPQYPRQD FRLRFRNMSA 300
    GAVDLLEKML VFDPSRRITV DEALHHPYLA SLHDINEEPT CPAPFSFDFE 350
    QPSFTEEHIK ELIWRESLAF NPDPPY 376
    Length:376
    Mass (Da):42,773
    Last modified:December 6, 2005 - v1
    Checksum:i700EC7AAEE91AA45
    GO

    Sequence cautioni

    The sequence AK111579 differs from that shown. Reason: Frameshift at position 359.
    The sequence AAM88622.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092389 Genomic DNA. Translation: AAM88622.1. Sequence problems.
    DP000086 Genomic DNA. Translation: ABB47925.1.
    AP008216 Genomic DNA. Translation: BAF27070.1.
    AK111579 mRNA. No translation available.
    RefSeqiNP_001065156.1. NM_001071691.1.
    UniGeneiOs.15044.

    Genome annotation databases

    EnsemblPlantsiOS10T0533600-01; OS10T0533600-01; OS10G0533600.
    GeneIDi4349225.
    KEGGiosa:4349225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092389 Genomic DNA. Translation: AAM88622.1 . Sequence problems.
    DP000086 Genomic DNA. Translation: ABB47925.1 .
    AP008216 Genomic DNA. Translation: BAF27070.1 .
    AK111579 mRNA. No translation available.
    RefSeqi NP_001065156.1. NM_001071691.1.
    UniGenei Os.15044.

    3D structure databases

    ProteinModelPortali Q336X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q336X9. 1 interaction.
    MINTi MINT-7234445.

    Proteomic databases

    PRIDEi Q336X9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS10T0533600-01 ; OS10T0533600-01 ; OS10G0533600 .
    GeneIDi 4349225.
    KEGGi osa:4349225.

    Organism-specific databases

    Gramenei Q336X9.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K04371.
    OMAi HENIISV.

    Enzyme and pathway databases

    Reactomei REACT_205014. CREB phosphorylation through the activation of Ras.
    REACT_214549. Signalling to ERK5.
    REACT_215626. ERK2 activation.
    REACT_221522. ERKs are inactivated.
    REACT_221537. ERK1 activation.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
      Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
      , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
      Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    5. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMPK6_ORYSJ
    AccessioniPrimary (citable) accession number: Q336X9
    Secondary accession number(s): Q0IW45, Q8LN33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3