ID CDKE1_ORYSJ Reviewed; 475 AA. AC Q336M2; B7ECP4; Q9FRN5; DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2006, sequence version 2. DT 27-MAR-2024, entry version 130. DE RecName: Full=Cyclin-dependent kinase E-1; DE Short=CDKE;1; DE EC=2.7.11.22; DE EC=2.7.11.23; GN Name=CDKE-1; OrderedLocusNames=Os10g0580300, LOC_Os10g42950; GN ORFNames=OsJ_32608 {ECO:0000312|EMBL:EEE51472.1}, OSJNBa0056G17.11; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=12791992; DOI=10.1126/science.1083523; RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M., RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.; RT "In-depth view of structure, activity, and evolution of rice chromosome RT 10."; RL Science 300:1566-1569(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [4] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=24280374; DOI=10.1186/1939-8433-6-4; RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R., RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L., RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H., RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.; RT "Improvement of the Oryza sativa Nipponbare reference genome using next RT generation sequence and optical map data."; RL Rice 6:4-4(2013). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038; RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L., RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.; RT "The genomes of Oryza sativa: a history of duplications."; RL PLoS Biol. 3:266-281(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Nipponbare; RX PubMed=12869764; DOI=10.1126/science.1081288; RG The rice full-length cDNA consortium; RT "Collection, mapping, and annotation of over 28,000 cDNA clones from RT japonica rice."; RL Science 301:376-379(2003). RN [7] RP INDUCTION, AND GENE FAMILY. RX PubMed=17443292; DOI=10.1007/s11103-007-9154-y; RA Guo J., Song J., Wang F., Zhang X.S.; RT "Genome-wide identification and expression analysis of rice cell cycle RT genes."; RL Plant Mol. Biol. 64:349-360(2007). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; CC EC=2.7.11.22; CC -!- CATALYTIC ACTIVITY: CC Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- CC [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- CC COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, CC ChEBI:CHEBI:456216; EC=2.7.11.23; CC -!- INDUCTION: By auxin. Down-regulated by cytokinin. CC {ECO:0000269|PubMed:17443292}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr CC protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC018727; AAG46164.1; -; Genomic_DNA. DR EMBL; DP000086; ABB48043.2; -; Genomic_DNA. DR EMBL; AP008216; BAF27349.1; -; Genomic_DNA. DR EMBL; AP014966; BAT12249.1; -; Genomic_DNA. DR EMBL; CM000147; EEE51472.1; -; Genomic_DNA. DR EMBL; AK066824; BAG90141.1; -; mRNA. DR RefSeq; XP_015614383.1; XM_015758897.1. DR AlphaFoldDB; Q336M2; -. DR SMR; Q336M2; -. DR STRING; 39947.Q336M2; -. DR PaxDb; 39947-Q336M2; -. DR EnsemblPlants; Os10t0580300-01; Os10t0580300-01; Os10g0580300. DR GeneID; 4349519; -. DR Gramene; Os10t0580300-01; Os10t0580300-01; Os10g0580300. DR KEGG; osa:4349519; -. DR eggNOG; KOG0666; Eukaryota. DR HOGENOM; CLU_000288_181_6_1; -. DR InParanoid; Q336M2; -. DR OMA; YFKNGGP; -. DR OrthoDB; 46620at2759; -. DR Proteomes; UP000000763; Chromosome 10. DR Proteomes; UP000007752; Chromosome 10. DR Proteomes; UP000059680; Chromosome 10. DR GO; GO:0016592; C:mediator complex; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central. DR GO; GO:0008353; F:RNA polymerase II CTD heptapeptide repeat kinase activity; IEA:UniProtKB-EC. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR CDD; cd07842; STKc_CDK8_like; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR24056; CELL DIVISION PROTEIN KINASE; 1. DR PANTHER; PTHR24056:SF495; CYCLIN-DEPENDENT KINASE 8; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR Genevisible; Q336M2; OS. PE 2: Evidence at transcript level; KW ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; KW Reference proteome; Serine/threonine-protein kinase; Transferase. FT CHAIN 1..475 FT /note="Cyclin-dependent kinase E-1" FT /id="PRO_0000296104" FT DOMAIN 19..337 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REGION 366..397 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 438..475 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 368..391 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 158 FT /note="Proton acceptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, FT ECO:0000255|PROSITE-ProRule:PRU10027" FT BINDING 25..33 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 59 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT MOD_RES 29 FT /note="Phosphothreonine" FT /evidence="ECO:0000250" FT MOD_RES 30 FT /note="Phosphotyrosine" FT /evidence="ECO:0000250" SQ SEQUENCE 475 AA; 52808 MW; D7CD5C959C39C349 CRC64; MGDGRVGGGT NRPAWLQQYE LVGKIGEGTY GLVFLARLKQ SHPHAAAGVG RRGSPIAIKK FKQSKEGDGV SPTAIREIML LREINHENVV KLVNVHINHA DMSLYLAFDY AEHDLYEIIR HHREKLNLPI NPYTVKSLLW QLLNGLNYLH SNWIIHRDLK PSNILVMGEG EEHGIIKIAD FGLARIYQAP LKPLSDNGVV VTIWYRAPEL LLGAKHYTSA VDMWAVGCIF AELLTLKPLF QGVEAKATPN PFQLDQLDKI FKVLGHPTVE KWPTLANLPC WQNDQQHIQG HKYENTGLHN IVHLPQKSPA FDLLSKMLEY DPRKRITAAQ ALEHEYFRMD PLPGRNALLP SQAGEKIVQY PVRPVDTTTD FEGTTSLQPT QAPSGNAAPG NQSVVPRPIP RQMQQPMVGM SRMGGTNMAA FGAAPQGGIA GMNPGNIPMQ RGAGAQSHPH QLRRKADQGM GMQNPGYPTQ QKRRF //