Reviewed, UniProtKB/Swiss-Prot Q33439 (COX1_EPHEQ)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I

Gene names

Name:	COX1
Synonyms:	COI, COXI

Encoded on

Mitochondrion

Organism

Ephedra equisetifolia

Taxonomic identifier

49760 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Gnetophyta › Gnetopsida › Ephedrales › Ephedraceae › Ephedra

Protein attributes

Sequence length	172 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›172	›172	Cytochrome c oxidase subunit 1		PRO_0000183332
Regions
	Transmembrane	31 – 51	21	Potential
	Transmembrane	63 – 83	21	Potential
	Transmembrane	106 – 126	21	Potential
	Transmembrane	134 – 154	21	Potential
Sites
	Metal binding	37	1	Copper B Probable
	Metal binding	41	1	Copper B Probable
	Metal binding	86	1	Copper B Probable
	Metal binding	87	1	Copper B Probable
	Metal binding	172	1	Iron (heme A3 axial ligand) Probable
Amino acid modifications
	Cross-link	37 ↔ 41		1'-histidyl-3'-tyrosine (His-Tyr) By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	172	1

Sequences

	Sequence		Length	Mass (Da)
	Q33439-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 40B1CD5A5A9643C0	FASTA	172	18,799
	10 20 30 40 50 60 GAITMLLTDR NFNTTFFDPA GGGDPILYQH LFWFFGHPEV YILILPGFGI ISQIVSTLSG 70 80 90 100 110 120 KQVFGYLGMV YAMISIGVLG FMVWAHHMFT VGLDVDTRAY FTAATMIIAV PTGIKIFSWI 130 140 150 160 170 ATMWGGSIRS ITPMLFAVGF LFLFTIGGLT GIVLANSGLD IALHDTYYVV AH

References

[1]	"Universality of mitochondrial RNA editing in cytochrome-c oxidase subunit I (coxI) among the land plants." Sper-Whitis G.L., Moody J.L., Vaughn J.C. Biochim. Biophys. Acta 1307:301-308(1996) [PubMed: 8688465] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94586 Genomic DNA. Translation: CAA64279.1.
3D structure databases
SMR	Q33439. Positions 2-172.
ModBase	Search...
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_EPHEQ

Accession

Primary (citable) accession number: Q33439

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	October 13, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)