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Q33439 (COX1_EPHEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COX1
Synonyms:COI, COXI
Encoded onMitochondrion
OrganismEphedra equisetifolia
Taxonomic identifier49760 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaGnetidaeEphedralesEphedraceaeEphedra

Protein attributes

Sequence length172 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›172›172Cytochrome c oxidase subunit 1
PRO_0000183332

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane134 – 15421Helical; Potential

Sites

Metal binding371Copper B Probable
Metal binding411Copper B Probable
Metal binding861Copper B Probable
Metal binding871Copper B Probable
Metal binding1721Iron (heme A3 axial ligand) Probable

Amino acid modifications

Cross-link37 ↔ 411'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1721

Sequences

Sequence LengthMass (Da)Tools
Q33439 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 40B1CD5A5A9643C0

FASTA17218,799
        10         20         30         40         50         60 
GAITMLLTDR NFNTTFFDPA GGGDPILYQH LFWFFGHPEV YILILPGFGI ISQIVSTLSG 

        70         80         90        100        110        120 
KQVFGYLGMV YAMISIGVLG FMVWAHHMFT VGLDVDTRAY FTAATMIIAV PTGIKIFSWI 

       130        140        150        160        170 
ATMWGGSIRS ITPMLFAVGF LFLFTIGGLT GIVLANSGLD IALHDTYYVV AH 

« Hide

References

[1]"Universality of mitochondrial RNA editing in cytochrome-c oxidase subunit I (coxI) among the land plants."
Sper-Whitis G.L., Moody J.L., Vaughn J.C.
Biochim. Biophys. Acta 1307:301-308(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94586 Genomic DNA. Translation: CAA64279.1.

3D structure databases

ProteinModelPortalQ33439.
SMRQ33439. Positions 2-172.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_EPHEQ
AccessionPrimary (citable) accession number: Q33439
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways