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Q33439

- COX1_EPHEQ

UniProt

Q33439 - COX1_EPHEQ

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COI, COXI
Organism
Ephedra equisetifolia
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Copper B Inferred
Metal bindingi41 – 411Copper B Inferred
Metal bindingi86 – 861Copper B Inferred
Metal bindingi87 – 871Copper B Inferred
Metal bindingi172 – 1721Iron (heme A3 axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COI, COXI
Encoded oniMitochondrion
OrganismiEphedra equisetifolia
Taxonomic identifieri49760 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaGnetidaeEphedralesEphedraceaeEphedra

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Transmembranei134 – 15421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›172›172Cytochrome c oxidase subunit 1
PRO_0000183332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki37 ↔ 411'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ33439.
SMRiQ33439. Positions 2-172.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q33439-1 [UniParc]FASTAAdd to Basket

« Hide

GAITMLLTDR NFNTTFFDPA GGGDPILYQH LFWFFGHPEV YILILPGFGI    50
ISQIVSTLSG KQVFGYLGMV YAMISIGVLG FMVWAHHMFT VGLDVDTRAY 100
FTAATMIIAV PTGIKIFSWI ATMWGGSIRS ITPMLFAVGF LFLFTIGGLT 150
GIVLANSGLD IALHDTYYVV AH 172
Length:172
Mass (Da):18,799
Last modified:November 1, 1997 - v1
Checksum:i40B1CD5A5A9643C0
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei172 – 1721

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94586 Genomic DNA. Translation: CAA64279.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94586 Genomic DNA. Translation: CAA64279.1 .

3D structure databases

ProteinModelPortali Q33439.
SMRi Q33439. Positions 2-172.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Universality of mitochondrial RNA editing in cytochrome-c oxidase subunit I (coxI) among the land plants."
    Sper-Whitis G.L., Moody J.L., Vaughn J.C.
    Biochim. Biophys. Acta 1307:301-308(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiCOX1_EPHEQ
AccessioniPrimary (citable) accession number: Q33439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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