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Protein

Phospholipid phosphatase-related protein type 5

Gene

PLPPR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 5Curated (EC:3.1.3.-)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 5Curated
Phosphatidic acid phosphatase type 2d1 Publication
Plasticity-related gene 5 protein1 Publication
Short name:
PRG-5
Gene namesi
Name:PLPPR5Imported
Synonyms:LPPR5Imported, PAP2D1 Publication, PRG51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31703. PLPPR5.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Transmembranei196 – 21318HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiLPPR5.
DMDMi172046620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Phospholipid phosphatase-related protein type 5PRO_0000321933Add
BLAST

Proteomic databases

PaxDbiQ32ZL2.
PeptideAtlasiQ32ZL2.
PRIDEiQ32ZL2.

PTM databases

DEPODiQ32ZL2.
iPTMnetiQ32ZL2.
PhosphoSiteiQ32ZL2.

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiQ32ZL2.
GenevisibleiQ32ZL2. HS.

Organism-specific databases

HPAiHPA018072.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263177.

Structurei

3D structure databases

ProteinModelPortaliQ32ZL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ32ZL2.
KOiK19581.
OMAiQGFFCYE.
PhylomeDBiQ32ZL2.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028680. LPPR5.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF17. PTHR10165:SF17. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32ZL2-1) [UniParc]FASTAAdd to basket

Also known as: PAP2d_v1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLLPAALTS SMLYFQMVIM AGTVMLAYYF EYTDTFTVNV QGFFCHDSAY
60 70 80 90 100
RKPYPGPEDS SAVPPVLLYS LAAGVPVLVI IVGETAVFCL QLATRDFENQ
110 120 130 140 150
EKTILTGDCC YINPLVRRTV RFLGIYTFGL FATDIFVNAG QVVTGNLAPH
160 170 180 190 200
FLALCKPNYT ALGCQQYTQF ISGEEACTGN PDLIMRARKT FPSKEAALSV
210 220 230 240 250
YAAMYLTMYI TNTIKAKGTR LAKPVLCLGL MCLAFLTGLN RVAEYRNHWS
260 270 280 290 300
DVIAGFLVGI SIAVFLVVCV VNNFKGRQAE NEHIHMDNLA QMPMISIPRV
310 320
ESPLEKVTSV QNHITAFAEV T
Length:321
Mass (Da):35,427
Last modified:February 26, 2008 - v2
Checksum:i2B1915ED740EE572
GO
Isoform 2 (identifier: Q32ZL2-2) [UniParc]FASTAAdd to basket

Also known as: PAP2d_v2

The sequence of this isoform differs from the canonical sequence as follows:
     307-311: Missing.

Show »
Length:316
Mass (Da):34,913
Checksum:i8BE4612CEA0356F3
GO

Sequence cautioni

The sequence AAH40174.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei307 – 3115Missing in isoform 2. 2 PublicationsVSP_031828

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574039 mRNA. Translation: AAS76645.1.
AY634620 mRNA. Translation: AAT64918.1.
FJ472844 mRNA. Translation: ACJ60628.1.
AL445433, AL161744, AL590110 Genomic DNA. Translation: CAH71558.1.
AL590110, AL161744, AL445433 Genomic DNA. Translation: CAH71749.1.
AL161744, AL445433, AL590110 Genomic DNA. Translation: CAI22993.1.
CH471097 Genomic DNA. Translation: EAW72994.1.
BC040174 mRNA. Translation: AAH40174.1. Different initiation.
BC136350 mRNA. Translation: AAI36351.1.
BC144000 mRNA. Translation: AAI44001.1.
CCDSiCCDS30778.1. [Q32ZL2-1]
CCDS30779.1. [Q32ZL2-2]
RefSeqiNP_001010861.1. NM_001010861.2. [Q32ZL2-2]
NP_001032394.1. NM_001037317.1. [Q32ZL2-1]
UniGeneiHs.483948.

Genome annotation databases

EnsembliENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1]
ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2]
GeneIDi163404.
KEGGihsa:163404.
UCSCiuc001dsb.4. human. [Q32ZL2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574039 mRNA. Translation: AAS76645.1.
AY634620 mRNA. Translation: AAT64918.1.
FJ472844 mRNA. Translation: ACJ60628.1.
AL445433, AL161744, AL590110 Genomic DNA. Translation: CAH71558.1.
AL590110, AL161744, AL445433 Genomic DNA. Translation: CAH71749.1.
AL161744, AL445433, AL590110 Genomic DNA. Translation: CAI22993.1.
CH471097 Genomic DNA. Translation: EAW72994.1.
BC040174 mRNA. Translation: AAH40174.1. Different initiation.
BC136350 mRNA. Translation: AAI36351.1.
BC144000 mRNA. Translation: AAI44001.1.
CCDSiCCDS30778.1. [Q32ZL2-1]
CCDS30779.1. [Q32ZL2-2]
RefSeqiNP_001010861.1. NM_001010861.2. [Q32ZL2-2]
NP_001032394.1. NM_001037317.1. [Q32ZL2-1]
UniGeneiHs.483948.

3D structure databases

ProteinModelPortaliQ32ZL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263177.

PTM databases

DEPODiQ32ZL2.
iPTMnetiQ32ZL2.
PhosphoSiteiQ32ZL2.

Polymorphism and mutation databases

BioMutaiLPPR5.
DMDMi172046620.

Proteomic databases

PaxDbiQ32ZL2.
PeptideAtlasiQ32ZL2.
PRIDEiQ32ZL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1]
ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2]
GeneIDi163404.
KEGGihsa:163404.
UCSCiuc001dsb.4. human. [Q32ZL2-1]

Organism-specific databases

CTDi163404.
GeneCardsiLPPR5.
H-InvDBHIX0000807.
HGNCiHGNC:31703. PLPPR5.
HPAiHPA018072.
neXtProtiNX_Q32ZL2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ32ZL2.
KOiK19581.
OMAiQGFFCYE.
PhylomeDBiQ32ZL2.

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR5. human.
GenomeRNAii163404.
PROiQ32ZL2.

Gene expression databases

BgeeiQ32ZL2.
GenevisibleiQ32ZL2. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028680. LPPR5.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF17. PTHR10165:SF17. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human phosphatidic acid phosphatase type 2, PAP2d, with two different transcripts PAP2d_v1 and PAP2d_v2."
    Sun L., Gu S., Sun Y., Zheng D., Wu Q., Li X., Dai J., Dai J., Ji C., Xie Y., Mao Y.
    Mol. Cell. Biochem. 272:91-96(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction."
    Broggini T., Nitsch R., Savaskan N.E.
    Mol. Biol. Cell 21:521-537(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.

Entry informationi

Entry nameiPLPR5_HUMAN
AccessioniPrimary (citable) accession number: Q32ZL2
Secondary accession number(s): A8MPX4
, B7UCH3, Q32ZD0, Q3ZCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.