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Protein

Phospholipid phosphatase-related protein type 5

Gene

PLPPR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 5Curated (EC:3.1.3.-)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 5Curated
Phosphatidic acid phosphatase type 2d1 Publication
Plasticity-related gene 5 protein1 Publication
Short name:
PRG-5
Gene namesi
Name:PLPPR5Imported
Synonyms:LPPR5Imported, PAP2D1 Publication, PRG51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31703. PLPPR5.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei196 – 213HelicalSequence analysisAdd BLAST18
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117598.

Polymorphism and mutation databases

BioMutaiLPPR5.
DMDMi172046620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219331 – 321Phospholipid phosphatase-related protein type 5Add BLAST321

Proteomic databases

PaxDbiQ32ZL2.
PeptideAtlasiQ32ZL2.
PRIDEiQ32ZL2.

PTM databases

DEPODiQ32ZL2.
iPTMnetiQ32ZL2.
PhosphoSitePlusiQ32ZL2.

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000117598.
GenevisibleiQ32ZL2. HS.

Organism-specific databases

HPAiHPA018072.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263177.

Structurei

3D structure databases

ProteinModelPortaliQ32ZL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ32ZL2.
KOiK19581.
OMAiQGFFCYE.
OrthoDBiEOG091G0870.
PhylomeDBiQ32ZL2.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028680. LPPR5.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF17. PTHR10165:SF17. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32ZL2-1) [UniParc]FASTAAdd to basket
Also known as: PAP2d_v1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLLPAALTS SMLYFQMVIM AGTVMLAYYF EYTDTFTVNV QGFFCHDSAY
60 70 80 90 100
RKPYPGPEDS SAVPPVLLYS LAAGVPVLVI IVGETAVFCL QLATRDFENQ
110 120 130 140 150
EKTILTGDCC YINPLVRRTV RFLGIYTFGL FATDIFVNAG QVVTGNLAPH
160 170 180 190 200
FLALCKPNYT ALGCQQYTQF ISGEEACTGN PDLIMRARKT FPSKEAALSV
210 220 230 240 250
YAAMYLTMYI TNTIKAKGTR LAKPVLCLGL MCLAFLTGLN RVAEYRNHWS
260 270 280 290 300
DVIAGFLVGI SIAVFLVVCV VNNFKGRQAE NEHIHMDNLA QMPMISIPRV
310 320
ESPLEKVTSV QNHITAFAEV T
Length:321
Mass (Da):35,427
Last modified:February 26, 2008 - v2
Checksum:i2B1915ED740EE572
GO
Isoform 2 (identifier: Q32ZL2-2) [UniParc]FASTAAdd to basket
Also known as: PAP2d_v2

The sequence of this isoform differs from the canonical sequence as follows:
     307-311: Missing.

Show »
Length:316
Mass (Da):34,913
Checksum:i8BE4612CEA0356F3
GO

Sequence cautioni

The sequence AAH40174 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031828307 – 311Missing in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574039 mRNA. Translation: AAS76645.1.
AY634620 mRNA. Translation: AAT64918.1.
FJ472844 mRNA. Translation: ACJ60628.1.
AL445433, AL161744, AL590110 Genomic DNA. Translation: CAH71558.1.
AL590110, AL161744, AL445433 Genomic DNA. Translation: CAH71749.1.
AL161744, AL445433, AL590110 Genomic DNA. Translation: CAI22993.1.
CH471097 Genomic DNA. Translation: EAW72994.1.
BC040174 mRNA. Translation: AAH40174.1. Different initiation.
BC136350 mRNA. Translation: AAI36351.1.
BC144000 mRNA. Translation: AAI44001.1.
CCDSiCCDS30778.1. [Q32ZL2-1]
CCDS30779.1. [Q32ZL2-2]
RefSeqiNP_001010861.1. NM_001010861.2. [Q32ZL2-2]
NP_001032394.1. NM_001037317.1. [Q32ZL2-1]
UniGeneiHs.483948.

Genome annotation databases

EnsembliENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1]
ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2]
GeneIDi163404.
KEGGihsa:163404.
UCSCiuc001dsb.4. human. [Q32ZL2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574039 mRNA. Translation: AAS76645.1.
AY634620 mRNA. Translation: AAT64918.1.
FJ472844 mRNA. Translation: ACJ60628.1.
AL445433, AL161744, AL590110 Genomic DNA. Translation: CAH71558.1.
AL590110, AL161744, AL445433 Genomic DNA. Translation: CAH71749.1.
AL161744, AL445433, AL590110 Genomic DNA. Translation: CAI22993.1.
CH471097 Genomic DNA. Translation: EAW72994.1.
BC040174 mRNA. Translation: AAH40174.1. Different initiation.
BC136350 mRNA. Translation: AAI36351.1.
BC144000 mRNA. Translation: AAI44001.1.
CCDSiCCDS30778.1. [Q32ZL2-1]
CCDS30779.1. [Q32ZL2-2]
RefSeqiNP_001010861.1. NM_001010861.2. [Q32ZL2-2]
NP_001032394.1. NM_001037317.1. [Q32ZL2-1]
UniGeneiHs.483948.

3D structure databases

ProteinModelPortaliQ32ZL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263177.

PTM databases

DEPODiQ32ZL2.
iPTMnetiQ32ZL2.
PhosphoSitePlusiQ32ZL2.

Polymorphism and mutation databases

BioMutaiLPPR5.
DMDMi172046620.

Proteomic databases

PaxDbiQ32ZL2.
PeptideAtlasiQ32ZL2.
PRIDEiQ32ZL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1]
ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2]
GeneIDi163404.
KEGGihsa:163404.
UCSCiuc001dsb.4. human. [Q32ZL2-1]

Organism-specific databases

CTDi163404.
GeneCardsiLPPR5.
H-InvDBHIX0000807.
HGNCiHGNC:31703. PLPPR5.
HPAiHPA018072.
neXtProtiNX_Q32ZL2.
OpenTargetsiENSG00000117598.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB5. Eukaryota.
ENOG410XYPV. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ32ZL2.
KOiK19581.
OMAiQGFFCYE.
OrthoDBiEOG091G0870.
PhylomeDBiQ32ZL2.

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR5. human.
GenomeRNAii163404.
PROiQ32ZL2.

Gene expression databases

BgeeiENSG00000117598.
GenevisibleiQ32ZL2. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028680. LPPR5.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF17. PTHR10165:SF17. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR5_HUMAN
AccessioniPrimary (citable) accession number: Q32ZL2
Secondary accession number(s): A8MPX4
, B7UCH3, Q32ZD0, Q3ZCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.