PLPPR5

Functionⁱ

Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.By similarity

GO - Molecular functionⁱ

lipid phosphatase activity Source: GO_Central
phosphatidate phosphatase activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

phospholipid dephosphorylation Source: GO_Central
phospholipid metabolic process Source: GO_Central
positive regulation of filopodium assembly Source: UniProtKB
positive regulation of neuron projection development Source: UniProtKB
signal transduction Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

BRENDAⁱ	3.1.3.4. 2681.
Reactomeⁱ	R-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phospholipid phosphatase-related protein type 5Curated (EC:3.1.3.-) Alternative name(s): Lipid phosphate phosphatase-related protein type 5Curated Phosphatidic acid phosphatase type 2d1 Publication Plasticity-related gene 5 protein1 Publication Short name: PRG-5
Gene namesⁱ	Name:PLPPR5Imported Synonyms:LPPR5Imported, PAP2D1 Publication, PRG51 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31703. PLPPR5.

HGNCⁱ

HGNC:31703. PLPPR5.

Subcellular locationⁱ

Cell membrane
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q8BJ52 (PLPR5_MOUSE)
; Multi-pass membrane protein
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q8BJ52 (PLPR5_MOUSE)

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	10 – 30	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	62 – 82	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	122 – 142	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	196 – 213	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	225 – 245	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	252 – 272	HelicalSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

integral component of plasma membrane Source: GO_Central
plasma membrane Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000117598.

OpenTargetsⁱ

ENSG00000117598.

Polymorphism and mutation databases

BioMutaⁱ	LPPR5.
DMDMⁱ	172046620.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000321933	1 – 321	Phospholipid phosphatase-related protein type 5Add BLAST		321

Proteomic databases

PaxDbⁱ	Q32ZL2.
PRIDEⁱ	Q32ZL2.

PTM databases

DEPODⁱ	Q32ZL2.
iPTMnetⁱ	Q32ZL2.
PhosphoSitePlusⁱ	Q32ZL2.

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000117598.
Genevisibleⁱ	Q32ZL2. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018072.

HPAⁱ

HPA018072.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q32ZL2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PA-phosphatase related phosphoesterase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410ITB5. Eukaryota. ENOG410XYPV. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000087654.
HOGENOMⁱ	HOG000286008.
HOVERGENⁱ	HBG108093.
InParanoidⁱ	Q32ZL2.
KEGG Orthology (KO) More...KOⁱ	K19581.
OMAⁱ	AMYLAMY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0870.
PhylomeDBⁱ	Q32ZL2.

Family and domain databases

Gene3Dⁱ	1.20.144.10. 1 hit.
InterProⁱ	View protein in InterPro IPR028680. LPPR5. IPR000326. P_Acid_Pase_2/haloperoxidase.
PANTHERⁱ	PTHR10165:SF117. PTHR10165:SF117. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01569. PAP2. 1 hit.
SMARTⁱ	View protein in SMART SM00014. acidPPc. 1 hit.
SUPFAMⁱ	SSF48317. SSF48317. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q32ZL2-1) [UniParc]FASTA Add to basket

Also known as: PAP2d_v1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLLPAALTS SMLYFQMVIM AGTVMLAYYF EYTDTFTVNV QGFFCHDSAY 
        60         70         80         90        100
RKPYPGPEDS SAVPPVLLYS LAAGVPVLVI IVGETAVFCL QLATRDFENQ 
       110        120        130        140        150
EKTILTGDCC YINPLVRRTV RFLGIYTFGL FATDIFVNAG QVVTGNLAPH 
       160        170        180        190        200
FLALCKPNYT ALGCQQYTQF ISGEEACTGN PDLIMRARKT FPSKEAALSV 
       210        220        230        240        250
YAAMYLTMYI TNTIKAKGTR LAKPVLCLGL MCLAFLTGLN RVAEYRNHWS 
       260        270        280        290        300
DVIAGFLVGI SIAVFLVVCV VNNFKGRQAE NEHIHMDNLA QMPMISIPRV 
       310        320 
ESPLEKVTSV QNHITAFAEV T

Length:321

Mass (Da):35,427

Last modified:February 26, 2008 - v2

Checksum:ⁱ2B1915ED740EE572

GO

Isoform 2 (identifier: Q32ZL2-2) [UniParc]FASTA Add to basket

Also known as: PAP2d_v2

The sequence of this isoform differs from the canonical sequence as follows:
307-311: Missing.

« Hide

        10         20         30         40         50
MPLLPAALTS SMLYFQMVIM AGTVMLAYYF EYTDTFTVNV QGFFCHDSAY 
        60         70         80         90        100
RKPYPGPEDS SAVPPVLLYS LAAGVPVLVI IVGETAVFCL QLATRDFENQ 
       110        120        130        140        150
EKTILTGDCC YINPLVRRTV RFLGIYTFGL FATDIFVNAG QVVTGNLAPH 
       160        170        180        190        200
FLALCKPNYT ALGCQQYTQF ISGEEACTGN PDLIMRARKT FPSKEAALSV 
       210        220        230        240        250
YAAMYLTMYI TNTIKAKGTR LAKPVLCLGL MCLAFLTGLN RVAEYRNHWS 
       260        270        280        290        300
DVIAGFLVGI SIAVFLVVCV VNNFKGRQAE NEHIHMDNLA QMPMISIPRV 
       310 
ESPLEKNHIT AFAEVT

Show »

Length:316

Mass (Da):34,913

Checksum:ⁱ8BE4612CEA0356F3

GO

Sequence cautionⁱ

The sequence AAH40174 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031828	307 – 311	Missing in isoform 2. 2 Publications		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY574039 mRNA. Translation: AAS76645.1. AY634620 mRNA. Translation: AAT64918.1. FJ472844 mRNA. Translation: ACJ60628.1. AL445433, AL161744, AL590110 Genomic DNA. Translation: CAH71558.1. AL590110, AL161744, AL445433 Genomic DNA. Translation: CAH71749.1. AL161744, AL445433, AL590110 Genomic DNA. Translation: CAI22993.1. CH471097 Genomic DNA. Translation: EAW72994.1. BC040174 mRNA. Translation: AAH40174.1. Different initiation. BC136350 mRNA. Translation: AAI36351.1. BC144000 mRNA. Translation: AAI44001.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30778.1. [Q32ZL2-1] CCDS30779.1. [Q32ZL2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001010861.1. NM_001010861.2. [Q32ZL2-2] NP_001032394.1. NM_001037317.1. [Q32ZL2-1]
UniGeneⁱ	Hs.483948.

Genome annotation databases

Ensemblⁱ	ENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1] ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2]
GeneIDⁱ	163404.
KEGGⁱ	hsa:163404.
UCSC genome browser More...UCSCⁱ	uc001dsb.4. human. [Q32ZL2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY574039 mRNA. Translation: AAS76645.1. AY634620 mRNA. Translation: AAT64918.1. FJ472844 mRNA. Translation: ACJ60628.1. AL445433, AL161744, AL590110 Genomic DNA. Translation: CAH71558.1. AL590110, AL161744, AL445433 Genomic DNA. Translation: CAH71749.1. AL161744, AL445433, AL590110 Genomic DNA. Translation: CAI22993.1. CH471097 Genomic DNA. Translation: EAW72994.1. BC040174 mRNA. Translation: AAH40174.1. Different initiation. BC136350 mRNA. Translation: AAI36351.1. BC144000 mRNA. Translation: AAI44001.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30778.1. [Q32ZL2-1] CCDS30779.1. [Q32ZL2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001010861.1. NM_001010861.2. [Q32ZL2-2] NP_001032394.1. NM_001037317.1. [Q32ZL2-1]
UniGeneⁱ	Hs.483948.

3D structure databases

ProteinModelPortalⁱ	Q32ZL2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

DEPODⁱ	Q32ZL2.
iPTMnetⁱ	Q32ZL2.
PhosphoSitePlusⁱ	Q32ZL2.

Polymorphism and mutation databases

BioMutaⁱ	LPPR5.
DMDMⁱ	172046620.

Proteomic databases

PaxDbⁱ	Q32ZL2.
PRIDEⁱ	Q32ZL2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1] ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2]
GeneIDⁱ	163404.
KEGGⁱ	hsa:163404.
UCSC genome browser More...UCSCⁱ	uc001dsb.4. human. [Q32ZL2-1]

Organism-specific databases

CTDⁱ	163404.
GeneCardsⁱ	PLPPR5.
H-InvDBⁱ	HIX0000807.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31703. PLPPR5.
Human Protein Atlas More...HPAⁱ	HPA018072.
neXtProtⁱ	NX_Q32ZL2.
Open Targets More...OpenTargetsⁱ	ENSG00000117598.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ITB5. Eukaryota. ENOG410XYPV. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000087654.
HOGENOMⁱ	HOG000286008.
HOVERGENⁱ	HBG108093.
InParanoidⁱ	Q32ZL2.
KEGG Orthology (KO) More...KOⁱ	K19581.
OMAⁱ	AMYLAMY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0870.
PhylomeDBⁱ	Q32ZL2.

Enzyme and pathway databases

BRENDAⁱ	3.1.3.4. 2681.
Reactomeⁱ	R-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSⁱ	LPPR5. human.
GenomeRNAiⁱ	163404.
Protein Ontology More...PROⁱ	PR:Q32ZL2.

Gene expression databases

Bgeeⁱ	ENSG00000117598.
Genevisibleⁱ	Q32ZL2. HS.

Family and domain databases

Gene3Dⁱ	1.20.144.10. 1 hit.
InterProⁱ	View protein in InterPro IPR028680. LPPR5. IPR000326. P_Acid_Pase_2/haloperoxidase.
PANTHERⁱ	PTHR10165:SF117. PTHR10165:SF117. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01569. PAP2. 1 hit.
SMARTⁱ	View protein in SMART SM00014. acidPPc. 1 hit.
SUPFAMⁱ	SSF48317. SSF48317. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLPR5_HUMAN
Accessionⁱ	Q32ZL2Primary (citable) accession number: Q32ZL2 Secondary accession number(s): A8MPX4 , B7UCH3, Q32ZD0, Q3ZCU7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	July 5, 2017
	This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q32ZL2 (PLPR5_HUMAN)

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Phospholipid phosphatase-related protein type 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ