UniProtKB - Q32ZL2 (PLPR5_HUMAN)
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Protein
Phospholipid phosphatase-related protein type 5
Gene
PLPPR5
Organism
Homo sapiens (Human)
Status
Functioni
Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.By similarity
GO - Molecular functioni
- lipid phosphatase activity Source: GO_Central
- phosphatidate phosphatase activity Source: GO_Central
GO - Biological processi
- phospholipid dephosphorylation Source: GO_Central
- phospholipid metabolic process Source: GO_Central
- positive regulation of filopodium assembly Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.4. 2681. |
Reactomei | R-HSA-419408. Lysosphingolipid and LPA receptors. |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid phosphatase-related protein type 5Curated (EC:3.1.3.-)Alternative name(s): Lipid phosphate phosphatase-related protein type 5Curated Phosphatidic acid phosphatase type 2d1 Publication Plasticity-related gene 5 protein1 Publication Short name: PRG-5 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000117598.11. |
HGNCi | HGNC:31703. PLPPR5. |
neXtProti | NX_Q32ZL2. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 213 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 252 – 272 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 163404. |
OpenTargetsi | ENSG00000117598. |
Polymorphism and mutation databases
BioMutai | LPPR5. |
DMDMi | 172046620. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321933 | 1 – 321 | Phospholipid phosphatase-related protein type 5Add BLAST | 321 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 302 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q32ZL2. |
PRIDEi | Q32ZL2. |
PTM databases
DEPODi | Q32ZL2. |
iPTMneti | Q32ZL2. |
PhosphoSitePlusi | Q32ZL2. |
Expressioni
Tissue specificityi
Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000117598. |
Genevisiblei | Q32ZL2. HS. |
Organism-specific databases
HPAi | HPA018072. |
Family & Domainsi
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410ITB5. Eukaryota. ENOG410XYPV. LUCA. |
GeneTreei | ENSGT00620000087654. |
HOGENOMi | HOG000286008. |
HOVERGENi | HBG108093. |
InParanoidi | Q32ZL2. |
KOi | K19581. |
OMAi | AMYLAMY. |
OrthoDBi | EOG091G0870. |
PhylomeDBi | Q32ZL2. |
Family and domain databases
InterProi | View protein in InterPro IPR028680. LPPR5. IPR036938. P_Acid_Pase_2/haloperoxi_sf. IPR000326. P_Acid_Pase_2/haloperoxidase. |
PANTHERi | PTHR10165:SF17. PTHR10165:SF17. 1 hit. |
Pfami | View protein in Pfam PF01569. PAP2. 1 hit. |
SMARTi | View protein in SMART SM00014. acidPPc. 1 hit. |
SUPFAMi | SSF48317. SSF48317. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q32ZL2-1) [UniParc]FASTAAdd to basket
Also known as: PAP2d_v1
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPLLPAALTS SMLYFQMVIM AGTVMLAYYF EYTDTFTVNV QGFFCHDSAY
60 70 80 90 100
RKPYPGPEDS SAVPPVLLYS LAAGVPVLVI IVGETAVFCL QLATRDFENQ
110 120 130 140 150
EKTILTGDCC YINPLVRRTV RFLGIYTFGL FATDIFVNAG QVVTGNLAPH
160 170 180 190 200
FLALCKPNYT ALGCQQYTQF ISGEEACTGN PDLIMRARKT FPSKEAALSV
210 220 230 240 250
YAAMYLTMYI TNTIKAKGTR LAKPVLCLGL MCLAFLTGLN RVAEYRNHWS
260 270 280 290 300
DVIAGFLVGI SIAVFLVVCV VNNFKGRQAE NEHIHMDNLA QMPMISIPRV
310 320
ESPLEKVTSV QNHITAFAEV T
Sequence cautioni
The sequence AAH40174 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031828 | 307 – 311 | Missing in isoform 2. 2 Publications | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY574039 mRNA. Translation: AAS76645.1. AY634620 mRNA. Translation: AAT64918.1. FJ472844 mRNA. Translation: ACJ60628.1. AL445433 Genomic DNA. No translation available. AL590110 Genomic DNA. No translation available. AL161744 Genomic DNA. No translation available. CH471097 Genomic DNA. Translation: EAW72994.1. BC040174 mRNA. Translation: AAH40174.1. Different initiation. BC136350 mRNA. Translation: AAI36351.1. BC144000 mRNA. Translation: AAI44001.1. |
CCDSi | CCDS30778.1. [Q32ZL2-1] CCDS30779.1. [Q32ZL2-2] |
RefSeqi | NP_001010861.1. NM_001010861.2. [Q32ZL2-2] NP_001032394.1. NM_001037317.1. [Q32ZL2-1] |
UniGenei | Hs.483948. |
Genome annotation databases
Ensembli | ENST00000263177; ENSP00000263177; ENSG00000117598. [Q32ZL2-1] ENST00000370188; ENSP00000359207; ENSG00000117598. [Q32ZL2-2] |
GeneIDi | 163404. |
KEGGi | hsa:163404. |
UCSCi | uc001dsb.4. human. [Q32ZL2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | PLPR5_HUMAN | |
Accessioni | Q32ZL2Primary (citable) accession number: Q32ZL2 Secondary accession number(s): A8MPX4 Q3ZCU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 28, 2018 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |