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Q32ZH7

- DFB14_RAT

UniProt

Q32ZH7 - DFB14_RAT

Protein

Beta-defensin 14

Gene

Defb14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Has antibacterial activity.By similarity

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_199130. Defensins.
    REACT_199131. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 14
    Short name:
    BD-14
    Alternative name(s):
    Defensin, beta 14
    Gene namesi
    Name:Defb14
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi1561378. Defb14.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 6745Beta-defensin 14PRO_0000352699Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 62By similarity
    Disulfide bondi40 ↔ 55By similarity
    Disulfide bondi45 ↔ 63By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ32ZH7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ32ZH7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32ZH7.
    SMRiQ32ZH7. Positions 24-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40430.
    GeneTreeiENSGT00530000064280.
    HOGENOMiHOG000015465.
    HOVERGENiHBG004834.
    InParanoidiQ32ZH7.
    OMAiSCLPREE.
    OrthoDBiEOG7SJD7S.
    PhylomeDBiQ32ZH7.

    Family and domain databases

    InterProiIPR001855. Defensin_beta-typ.
    [Graphical view]
    PfamiPF00711. Defensin_beta. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q32ZH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLHYLLFVF LILFLVPAPG DTFIPKSLRR FFCRVRGGRC AILNCLGKEE   50
    QIGRCSNRGQ KCCRKKK 67
    Length:67
    Mass (Da):7,803
    Last modified:December 6, 2005 - v1
    Checksum:i635E5983B9A77734
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY621346 mRNA. Translation: AAT51885.1.
    RefSeqiNP_001032593.1. NM_001037504.1.
    XP_006253434.1. XM_006253372.1.
    XP_006253435.1. XM_006253373.1.
    UniGeneiRn.160439.

    Genome annotation databases

    EnsembliENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
    GeneIDi641627.
    KEGGirno:641627.
    UCSCiRGD:1561378. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY621346 mRNA. Translation: AAT51885.1 .
    RefSeqi NP_001032593.1. NM_001037504.1.
    XP_006253434.1. XM_006253372.1.
    XP_006253435.1. XM_006253373.1.
    UniGenei Rn.160439.

    3D structure databases

    ProteinModelPortali Q32ZH7.
    SMRi Q32ZH7. Positions 24-67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048330.

    Proteomic databases

    PRIDEi Q32ZH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000048414 ; ENSRNOP00000048330 ; ENSRNOG00000032304 .
    GeneIDi 641627.
    KEGGi rno:641627.
    UCSCi RGD:1561378. rat.

    Organism-specific databases

    CTDi 244332.
    RGDi 1561378. Defb14.

    Phylogenomic databases

    eggNOGi NOG40430.
    GeneTreei ENSGT00530000064280.
    HOGENOMi HOG000015465.
    HOVERGENi HBG004834.
    InParanoidi Q32ZH7.
    OMAi SCLPREE.
    OrthoDBi EOG7SJD7S.
    PhylomeDBi Q32ZH7.

    Enzyme and pathway databases

    Reactomei REACT_199130. Defensins.
    REACT_199131. Beta defensins.

    Miscellaneous databases

    NextBioi 714748.
    PROi Q32ZH7.

    Gene expression databases

    Genevestigatori Q32ZH7.

    Family and domain databases

    InterProi IPR001855. Defensin_beta-typ.
    [Graphical view ]
    Pfami PF00711. Defensin_beta. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDFB14_RAT
    AccessioniPrimary (citable) accession number: Q32ZH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3