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Q32ZH7 (DFB14_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 14

Short name=BD-14
Alternative name(s):
Defensin, beta 14
Gene names
Name:Defb14
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length67 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has antibacterial activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 6745Beta-defensin 14
PRO_0000352699

Amino acid modifications

Disulfide bond33 ↔ 62 By similarity
Disulfide bond40 ↔ 55 By similarity
Disulfide bond45 ↔ 63 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q32ZH7 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 635E5983B9A77734

FASTA677,803
        10         20         30         40         50         60 
MRLHYLLFVF LILFLVPAPG DTFIPKSLRR FFCRVRGGRC AILNCLGKEE QIGRCSNRGQ 


KCCRKKK 

« Hide

References

[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY621346 mRNA. Translation: AAT51885.1.
RefSeqNP_001032593.1. NM_001037504.1.
XP_006253434.1. XM_006253372.1.
XP_006253435.1. XM_006253373.1.
UniGeneRn.160439.

3D structure databases

ProteinModelPortalQ32ZH7.
SMRQ32ZH7. Positions 24-67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000048330.

Proteomic databases

PRIDEQ32ZH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
GeneID641627.
KEGGrno:641627.
UCSCRGD:1561378. rat.

Organism-specific databases

CTD244332.
RGD1561378. Defb14.

Phylogenomic databases

eggNOGNOG40430.
GeneTreeENSGT00530000064280.
HOGENOMHOG000015465.
HOVERGENHBG004834.
InParanoidQ32ZH7.
OMASCLPREE.
OrthoDBEOG7SJD7S.
PhylomeDBQ32ZH7.

Gene expression databases

GenevestigatorQ32ZH7.

Family and domain databases

InterProIPR001855. Defensin_beta-typ.
[Graphical view]
PfamPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio714748.
PROQ32ZH7.

Entry information

Entry nameDFB14_RAT
AccessionPrimary (citable) accession number: Q32ZH7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families