Q32ZH7 (DFB14_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 14
Short name=BD-14

Alternative name(s):
Defensin, beta 14

Gene names

Name:

Defb14

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has antibacterial activity By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 67	45	Beta-defensin 14		PRO_0000352699
Amino acid modifications
	Disulfide bond	33 ↔ 62		By similarity
	Disulfide bond	40 ↔ 55		By similarity
	Disulfide bond	45 ↔ 63		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q32ZH7 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 635E5983B9A77734	FASTA	67	7,803
	10 20 30 40 50 60 MRLHYLLFVF LILFLVPAPG DTFIPKSLRR FFCRVRGGRC AILNCLGKEE QIGRCSNRGQ KCCRKKK

References

[1]

"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY621346 mRNA. Translation: AAT51885.1.
IPI	IPI00564013.
RefSeq	NP_001032593.1. NM_001037504.1.
UniGene	Rn.160439.
3D structure databases
ProteinModelPortal	Q32ZH7.
SMR	Q32ZH7. Positions 24-67.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000048330.
Proteomic databases
PRIDE	Q32ZH7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
GeneID	641627.
KEGG	rno:641627.
UCSC	RGD:1561378. rat.
Organism-specific databases
CTD	244332.
RGD	1561378. Defb14.
Phylogenomic databases
eggNOG	NOG40430.
GeneTree	ENSGT00530000064280.
HOGENOM	HOG000015465.
HOVERGEN	HBG004834.
InParanoid	Q32ZH7.
OMA	SCLPREE.
OrthoDB	EOG4907BQ.
Gene expression databases
Genevestigator	Q32ZH7.
Family and domain databases
InterPro	IPR001855. Defensin_beta-typ. [Graphical view]
Pfam	PF00711. Defensin_beta. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	714748.

Entry information

Entry name

DFB14_RAT

Accession

Primary (citable) accession number: Q32ZH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program