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Q32ZH7

- DFB14_RAT

UniProt

Q32ZH7 - DFB14_RAT

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Protein
Beta-defensin 14
Gene
Defb14
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Has antibacterial activity By similarity.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_199130. Defensins.
REACT_199131. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 14
Short name:
BD-14
Alternative name(s):
Defensin, beta 14
Gene namesi
Name:Defb14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1561378. Defb14.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 6745Beta-defensin 14
PRO_0000352699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 62 By similarity
Disulfide bondi40 ↔ 55 By similarity
Disulfide bondi45 ↔ 63 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ32ZH7.

Expressioni

Gene expression databases

GenevestigatoriQ32ZH7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048330.

Structurei

3D structure databases

ProteinModelPortaliQ32ZH7.
SMRiQ32ZH7. Positions 24-67.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40430.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ32ZH7.
OMAiSCLPREE.
OrthoDBiEOG7SJD7S.
PhylomeDBiQ32ZH7.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32ZH7-1 [UniParc]FASTAAdd to Basket

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MRLHYLLFVF LILFLVPAPG DTFIPKSLRR FFCRVRGGRC AILNCLGKEE   50
QIGRCSNRGQ KCCRKKK 67
Length:67
Mass (Da):7,803
Last modified:December 6, 2005 - v1
Checksum:i635E5983B9A77734
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY621346 mRNA. Translation: AAT51885.1.
RefSeqiNP_001032593.1. NM_001037504.1.
XP_006253434.1. XM_006253372.1.
XP_006253435.1. XM_006253373.1.
UniGeneiRn.160439.

Genome annotation databases

EnsembliENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
GeneIDi641627.
KEGGirno:641627.
UCSCiRGD:1561378. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY621346 mRNA. Translation: AAT51885.1 .
RefSeqi NP_001032593.1. NM_001037504.1.
XP_006253434.1. XM_006253372.1.
XP_006253435.1. XM_006253373.1.
UniGenei Rn.160439.

3D structure databases

ProteinModelPortali Q32ZH7.
SMRi Q32ZH7. Positions 24-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048330.

Proteomic databases

PRIDEi Q32ZH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000048414 ; ENSRNOP00000048330 ; ENSRNOG00000032304 .
GeneIDi 641627.
KEGGi rno:641627.
UCSCi RGD:1561378. rat.

Organism-specific databases

CTDi 244332.
RGDi 1561378. Defb14.

Phylogenomic databases

eggNOGi NOG40430.
GeneTreei ENSGT00530000064280.
HOGENOMi HOG000015465.
HOVERGENi HBG004834.
InParanoidi Q32ZH7.
OMAi SCLPREE.
OrthoDBi EOG7SJD7S.
PhylomeDBi Q32ZH7.

Enzyme and pathway databases

Reactomei REACT_199130. Defensins.
REACT_199131. Beta defensins.

Miscellaneous databases

NextBioi 714748.
PROi Q32ZH7.

Gene expression databases

Genevestigatori Q32ZH7.

Family and domain databases

InterProi IPR001855. Defensin_beta-typ.
[Graphical view ]
Pfami PF00711. Defensin_beta. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDFB14_RAT
AccessioniPrimary (citable) accession number: Q32ZH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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