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Protein

Beta-defensin 14

Gene

Defb14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl

GO - Biological processi

  1. cell chemotaxis Source: Ensembl
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_199130. Defensins.
REACT_199131. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 14
Short name:
BD-14
Alternative name(s):
Defensin, beta 14
Gene namesi
Name:Defb14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1561378. Defb14.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 6745Beta-defensin 14PRO_0000352699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 62By similarity
Disulfide bondi40 ↔ 55By similarity
Disulfide bondi45 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ32ZH7.

Expressioni

Gene expression databases

GenevestigatoriQ32ZH7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048330.

Structurei

3D structure databases

ProteinModelPortaliQ32ZH7.
SMRiQ32ZH7. Positions 24-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40430.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ32ZH7.
OMAiSCLPREE.
OrthoDBiEOG7SJD7S.
PhylomeDBiQ32ZH7.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32ZH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLHYLLFVF LILFLVPAPG DTFIPKSLRR FFCRVRGGRC AILNCLGKEE
60
QIGRCSNRGQ KCCRKKK
Length:67
Mass (Da):7,803
Last modified:December 6, 2005 - v1
Checksum:i635E5983B9A77734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621346 mRNA. Translation: AAT51885.1.
RefSeqiNP_001032593.1. NM_001037504.1.
XP_006253434.1. XM_006253372.2.
UniGeneiRn.160439.

Genome annotation databases

EnsembliENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
GeneIDi641627.
KEGGirno:641627.
UCSCiRGD:1561378. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621346 mRNA. Translation: AAT51885.1.
RefSeqiNP_001032593.1. NM_001037504.1.
XP_006253434.1. XM_006253372.2.
UniGeneiRn.160439.

3D structure databases

ProteinModelPortaliQ32ZH7.
SMRiQ32ZH7. Positions 24-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048330.

Proteomic databases

PRIDEiQ32ZH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
GeneIDi641627.
KEGGirno:641627.
UCSCiRGD:1561378. rat.

Organism-specific databases

CTDi244332.
RGDi1561378. Defb14.

Phylogenomic databases

eggNOGiNOG40430.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ32ZH7.
OMAiSCLPREE.
OrthoDBiEOG7SJD7S.
PhylomeDBiQ32ZH7.

Enzyme and pathway databases

ReactomeiREACT_199130. Defensins.
REACT_199131. Beta defensins.

Miscellaneous databases

NextBioi714748.
PROiQ32ZH7.

Gene expression databases

GenevestigatoriQ32ZH7.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDFB14_RAT
AccessioniPrimary (citable) accession number: Q32ZH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 6, 2005
Last modified: January 7, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.