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Q32ZG8

- Q32ZG8_RAT

UniProt

Q32ZG8 - Q32ZG8_RAT

Protein

Beta-defensin

Gene

Defb24

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.UniRule annotation

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    AntibioticUniRule annotationSAAS annotation, Antimicrobial, DefensinUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensinUniRule annotation
    Gene namesi
    Name:Defb24Imported
    ORF Names:rCG_37392Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1559541. Defb24.

    Subcellular locationi

    Secreted UniRule annotation

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    SecretedUniRule annotationSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ32ZG8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052276.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.UniRule annotation

    Keywords - Domaini

    SignalUniRule annotation

    Phylogenomic databases

    eggNOGiNOG87541.
    GeneTreeiENSGT00510000050451.
    HOGENOMiHOG000112157.
    HOVERGENiHBG107794.
    InParanoidiQ32ZG8.
    OMAiVEDNTNW.
    OrthoDBiEOG7DZ8NX.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q32ZG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLVLLLLAI FVTTELVMSG KNPTLQCMGN RGFCRPSCKK GEQAYFYCRT   50
    YQICCLQSHV RISLTGVEDN TNWSYEKHWP RIP 83
    Length:83
    Mass (Da):9,618
    Last modified:December 6, 2005 - v1
    Checksum:i8254ED4079B41949
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06027068 Genomic DNA. No translation available.
    AY621355 mRNA. Translation: AAT51894.1.
    AY600148 mRNA. Translation: AAU04552.1.
    CH474050 Genomic DNA. Translation: EDL86062.1.
    RefSeqiNP_001032597.1. NM_001037508.1.
    UniGeneiRn.147317.

    Genome annotation databases

    EnsembliENSRNOT00000055408; ENSRNOP00000052276; ENSRNOG00000036897.
    GeneIDi641632.
    KEGGirno:641632.
    UCSCiRGD:1559541. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06027068 Genomic DNA. No translation available.
    AY621355 mRNA. Translation: AAT51894.1 .
    AY600148 mRNA. Translation: AAU04552.1 .
    CH474050 Genomic DNA. Translation: EDL86062.1 .
    RefSeqi NP_001032597.1. NM_001037508.1.
    UniGenei Rn.147317.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055408 ; ENSRNOP00000052276 ; ENSRNOG00000036897 .
    GeneIDi 641632.
    KEGGi rno:641632.
    UCSCi RGD:1559541. rat.

    Organism-specific databases

    CTDi 641632.
    RGDi 1559541. Defb24.

    Phylogenomic databases

    eggNOGi NOG87541.
    GeneTreei ENSGT00510000050451.
    HOGENOMi HOG000112157.
    HOVERGENi HBG107794.
    InParanoidi Q32ZG8.
    OMAi VEDNTNW.
    OrthoDBi EOG7DZ8NX.

    Miscellaneous databases

    NextBioi 714766.
    PROi Q32ZG8.

    Gene expression databases

    Genevestigatori Q32ZG8.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. "Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus)."
      Yenugu S., Chintalgattu V., Wingard C.J., Radhakrishnan Y., French F.S., Hall S.H.
      Reprod. Biol. Endocrinol. 4:7-7(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WImported.
      Tissue: EpididymisImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ32ZG8_RAT
    AccessioniPrimary (citable) accession number: Q32ZG8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3