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Protein

Beta-defensin 25

Gene

Defb25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 25
Short name:
BD-25
Alternative name(s):
Defensin, beta 25
Gene namesi
Name:Defb25
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1564765. Defb25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 7149Beta-defensin 25PRO_0000352708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ32ZG7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052274.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J58D. Eukaryota.
ENOG41117ZI. LUCA.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095686.
InParanoidiQ32ZG7.
OMAiTYCTRQE.
OrthoDBiEOG7V769B.
PhylomeDBiQ32ZG7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32ZG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWILLIVA LLVLGHVPSG STEFKRCWNG QGACRTYCTR QEKFIHLCPD
60 70
ASLCCLSYSL KASPHSRAGG V
Length:71
Mass (Da):7,781
Last modified:December 6, 2005 - v1
Checksum:iF1907585E9CA8CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621356 mRNA. Translation: AAT51895.1.
RefSeqiNP_001032605.1. NM_001037516.1.
UniGeneiRn.156440.

Genome annotation databases

EnsembliENSRNOT00000055406; ENSRNOP00000052274; ENSRNOG00000036895.
GeneIDi641644.
KEGGirno:641644.
UCSCiRGD:1564765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621356 mRNA. Translation: AAT51895.1.
RefSeqiNP_001032605.1. NM_001037516.1.
UniGeneiRn.156440.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052274.

Proteomic databases

PaxDbiQ32ZG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055406; ENSRNOP00000052274; ENSRNOG00000036895.
GeneIDi641644.
KEGGirno:641644.
UCSCiRGD:1564765. rat.

Organism-specific databases

CTDi654459.
RGDi1564765. Defb25.

Phylogenomic databases

eggNOGiENOG410J58D. Eukaryota.
ENOG41117ZI. LUCA.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095686.
InParanoidiQ32ZG7.
OMAiTYCTRQE.
OrthoDBiEOG7V769B.
PhylomeDBiQ32ZG7.

Miscellaneous databases

PROiQ32ZG7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDFB25_RAT
AccessioniPrimary (citable) accession number: Q32ZG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 6, 2005
Last modified: July 6, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.