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Protein

Beta-defensin 25

Gene

Defb25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 25
Short name:
BD-25
Alternative name(s):
Defensin, beta 25
Gene namesi
Name:Defb25
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1564765. Defb25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 7149Beta-defensin 25PRO_0000352708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ32ZG7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000036895.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052274.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J58D. Eukaryota.
ENOG41117ZI. LUCA.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095686.
InParanoidiQ32ZG7.
OMAiTYCTRQE.
OrthoDBiEOG091G15V3.
PhylomeDBiQ32ZG7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32ZG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWILLIVA LLVLGHVPSG STEFKRCWNG QGACRTYCTR QEKFIHLCPD
60 70
ASLCCLSYSL KASPHSRAGG V
Length:71
Mass (Da):7,781
Last modified:December 6, 2005 - v1
Checksum:iF1907585E9CA8CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621356 mRNA. Translation: AAT51895.1.
RefSeqiNP_001032605.1. NM_001037516.1.
UniGeneiRn.156440.

Genome annotation databases

EnsembliENSRNOT00000055406; ENSRNOP00000052274; ENSRNOG00000036895.
GeneIDi641644.
KEGGirno:641644.
UCSCiRGD:1564765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621356 mRNA. Translation: AAT51895.1.
RefSeqiNP_001032605.1. NM_001037516.1.
UniGeneiRn.156440.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052274.

Proteomic databases

PaxDbiQ32ZG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055406; ENSRNOP00000052274; ENSRNOG00000036895.
GeneIDi641644.
KEGGirno:641644.
UCSCiRGD:1564765. rat.

Organism-specific databases

CTDi654459.
RGDi1564765. Defb25.

Phylogenomic databases

eggNOGiENOG410J58D. Eukaryota.
ENOG41117ZI. LUCA.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095686.
InParanoidiQ32ZG7.
OMAiTYCTRQE.
OrthoDBiEOG091G15V3.
PhylomeDBiQ32ZG7.

Miscellaneous databases

PROiQ32ZG7.

Gene expression databases

BgeeiENSRNOG00000036895.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDFB25_RAT
AccessioniPrimary (citable) accession number: Q32ZG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.