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Protein

Bromodomain-containing protein 2

Gene

BRD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 2
Gene namesi
Name:BRD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

  • Nucleus By similarity

  • Note: Detected on chromatin and nucleosomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Bromodomain-containing protein 2PRO_0000239862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei6 – 61PhosphothreonineBy similarity
Modified residuei37 – 371PhosphoserineBy similarity
Modified residuei298 – 2981PhosphoserineBy similarity
Modified residuei301 – 3011PhosphoserineBy similarity
Modified residuei635 – 6351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ32S26.
PRIDEiQ32S26.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011074.

Interactioni

Subunit structurei

Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014704.

Structurei

3D structure databases

ProteinModelPortaliQ32S26.
SMRiQ32S26. Positions 73-186, 348-455, 639-716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 16373Bromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini364 – 43673Bromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini634 – 71683NETPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi556 – 5605Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi476 – 52651Glu/Ser-richAdd
BLAST
Compositional biasi545 – 56723Arg/Lys-rich (highly basic)Add
BLAST
Compositional biasi765 – 80238Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 bromo domains.PROSITE-ProRule annotation
Contains 1 NET domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000231200.
HOVERGENiHBG004896.
InParanoidiQ32S26.
KOiK08871.
OMAiTESSVAQ.
OrthoDBiEOG091G01QC.
TreeFamiTF317345.

Family and domain databases

Gene3Di1.20.920.10. 3 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32S26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS
60 70 80 90 100
VPALQLTPAN PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR
110 120 130 140 150
QPVDAVKLGL PDYHKIIKQP MDMGTIKRRL ENNYYWAASE CMQDFNTMFT
160 170 180 190 200
NCYIYNKPTD DIVLMAQTLE KIFLQKVASM PQEEQELVVT IPKNSHKKGA
210 220 230 240 250
KLAALQGSIT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI PHPSVISSPL
260 270 280 290 300
LKSLHSAGPP LLAVSAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA
310 320 330 340 350
SPPGGLEPKA ARLPPVRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL
360 370 380 390 400
KHCNGILKEL LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK
410 420 430 440 450
RKMENRDYRD AQEFAADVRL MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY
460 470 480 490 500
AKMPDEPLEP GPLPVSTALP PGLAKSSSES SSEESSSESS SEEEEEEDED
510 520 530 540 550
EEEEEEESES SDSEEERAHR LAELQEQLRA VHEQLAALSQ GPISKPKRKR
560 570 580 590 600
EKKEKKKKRK AEKHRGRAGA DEDDKGPRAP RPSQPKKSKK AGGGGSSGAA
610 620 630 640 650
TLGPPGFGPS GGGATKLPKK ATKTAPPALP AGYDSEEEEE SRPMSYDEKR
660 670 680 690 700
QLSLDINKLP GEKLGRVVHI IQAREPSLRD SNPEEIEIDF ETLKPSTLRE
710 720 730 740 750
LERYVLSCLR KKPRKPYTIK KPVGKTKEEL ALEKKRELEK RLQDVSGQLN
760 770 780 790 800
STKKPPKKAS EKTETSSAQQ VAVSRLSASS SSSDSSSSSS SSSSSDTSDS

DSG
Length:803
Mass (Da):88,122
Last modified:December 6, 2005 - v1
Checksum:iDE0F35E3A3A55D2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957499 Genomic DNA. Translation: AAY34703.1.
RefSeqiNP_001039331.1. NM_001045866.1.
XP_005223266.1. XM_005223209.3.
XP_005223267.1. XM_005223210.3.
XP_005223268.1. XM_005223211.3.
XP_015315205.1. XM_015459719.1.
XP_015315206.1. XM_015459720.1.
UniGeneiBt.33281.

Genome annotation databases

EnsembliENSBTAT00000014704; ENSBTAP00000014704; ENSBTAG00000011074.
GeneIDi505358.
KEGGibta:505358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957499 Genomic DNA. Translation: AAY34703.1.
RefSeqiNP_001039331.1. NM_001045866.1.
XP_005223266.1. XM_005223209.3.
XP_005223267.1. XM_005223210.3.
XP_005223268.1. XM_005223211.3.
XP_015315205.1. XM_015459719.1.
XP_015315206.1. XM_015459720.1.
UniGeneiBt.33281.

3D structure databases

ProteinModelPortaliQ32S26.
SMRiQ32S26. Positions 73-186, 348-455, 639-716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014704.

Proteomic databases

PaxDbiQ32S26.
PRIDEiQ32S26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014704; ENSBTAP00000014704; ENSBTAG00000011074.
GeneIDi505358.
KEGGibta:505358.

Organism-specific databases

CTDi6046.

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000231200.
HOVERGENiHBG004896.
InParanoidiQ32S26.
KOiK08871.
OMAiTESSVAQ.
OrthoDBiEOG091G01QC.
TreeFamiTF317345.

Gene expression databases

BgeeiENSBTAG00000011074.

Family and domain databases

Gene3Di1.20.920.10. 3 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRD2_BOVIN
AccessioniPrimary (citable) accession number: Q32S26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.