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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Staurastrum punctulatum (Green alga)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601Thiamine pyrophosphateBy similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Synonyms:odpB
Encoded oniPlastid; Chloroplast
OrganismiStaurastrum punctulatum (Green alga)
Taxonomic identifieri102822 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaZygnemophyceaeDesmidialesDesmidiaceaeStaurastrum

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Pyruvate dehydrogenase E1 component subunit betaPRO_0000280104Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ32RS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32RS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEMLLFEAL REGLQEEMDR DPKVLVMGED VGHYGGSYKV TKGFAEKYGD
60 70 80 90 100
LRLLDTPIAE NSFTGMAIGA AMTGLRPVVE GMNMGFLLLA FNQIANNAGM
110 120 130 140 150
LHYTSGANFT IPIVIRGPGG VGRQLGAEHS QRLESYFQSV PGLQLVACST
160 170 180 190 200
PINAKGLIKS SIRSENPVIL FEHVLLYNLK ETIPDNEYLV CLEKAEIVRP
210 220 230 240 250
GTDITILTYS RMRHHVLQAT KSLVYKGYDP EIIDIVSLKP VDLGTISTSI
260 270 280 290 300
KKTHKVLIVE ECMRTGGIGA SLRATIMEHL FDFLDAPIMC LSSQDVPTPY
310 320
SGPLEELTVI QPAQIVQAVE QLCNNGNN
Length:328
Mass (Da):35,943
Last modified:December 6, 2005 - v1
Checksum:i3E88A78FC2BB8F6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY958085 Genomic DNA. Translation: AAX45708.1.
RefSeqiYP_636456.1. NC_008116.1.

Genome annotation databases

GeneIDi4108657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY958085 Genomic DNA. Translation: AAX45708.1.
RefSeqiYP_636456.1. NC_008116.1.

3D structure databases

ProteinModelPortaliQ32RS0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4108657.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete chloroplast DNA sequences of the charophycean green algae Staurastrum and Zygnema reveal that the chloroplast genome underwent extensive changes during the evolution of the Zygnematales."
    Turmel M., Otis C., Lemieux C.
    BMC Biol. 3:22-22(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiODPB_STAPU
AccessioniPrimary (citable) accession number: Q32RS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 6, 2005
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.