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Protein

Uncharacterized protein C12orf74

Gene

C12orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf74
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:27887. C12orf74.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716804.

Polymorphism and mutation databases

BioMutaiC12orf74.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Uncharacterized protein C12orf74PRO_0000340230Add
BLAST

Proteomic databases

PaxDbiQ32Q52.
PRIDEiQ32Q52.

PTM databases

iPTMnetiQ32Q52.

Expressioni

Gene expression databases

BgeeiQ32Q52.
GenevisibleiQ32Q52. HS.

Organism-specific databases

HPAiHPA039294.

Interactioni

Protein-protein interaction databases

BioGridi130800. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ32Q52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J05W. Eukaryota.
ENOG41116A6. LUCA.
GeneTreeiENSGT00430000032851.
HOGENOMiHOG000111775.
InParanoidiQ32Q52.
OMAiSRCVCIY.
OrthoDBiEOG73FQP6.
PhylomeDBiQ32Q52.
TreeFamiTF353652.

Family and domain databases

InterProiIPR031448. DUF4675.
[Graphical view]
PfamiPF15720. DUF4675. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32Q52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKTESFCPE VPPQDCGASP RPSLRSLPKN QGSLLQFDRQ APGRISTSPT
60 70 80 90 100
LRRLRTRGCG TRQDAWQVTT WGSWGAPVGF PCYLSKSLPG SPKDSSHLLS
110 120 130 140 150
PLRLHSRLTS EPERALNAAD SLEPQTRPTD KYLPPELQPV NEGSLHQASL
160 170 180 190
RQQEGHFLPS PTLRHPSPQG EELHPSRCVC IYFLRCYDIC
Length:190
Mass (Da):21,196
Last modified:December 6, 2005 - v1
Checksum:iB3D26C9AF8F1C992
GO
Isoform 2 (identifier: Q32Q52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-190: GEELHPSRCVCIYFLRCYDIC → VTQL

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):19,136
Checksum:iCF2A20768E446F04
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei170 – 19021GEELH…CYDIC → VTQL in isoform 2. 1 PublicationVSP_045285Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016136 Genomic DNA. No translation available.
BC043363 mRNA. No translation available.
BC105728 mRNA. Translation: AAI05729.1.
BC107813 mRNA. Translation: AAI07814.1.
CCDSiCCDS41819.1. [Q32Q52-1]
CCDS53818.1. [Q32Q52-2]
RefSeqiNP_001032760.1. NM_001037671.3. [Q32Q52-1]
NP_001171568.1. NM_001178097.2. [Q32Q52-2]
UniGeneiHs.326303.

Genome annotation databases

EnsembliENST00000397833; ENSP00000380933; ENSG00000214215. [Q32Q52-1]
ENST00000544406; ENSP00000446043; ENSG00000214215. [Q32Q52-2]
GeneIDi338809.
KEGGihsa:338809.
UCSCiuc001tch.3. human. [Q32Q52-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016136 Genomic DNA. No translation available.
BC043363 mRNA. No translation available.
BC105728 mRNA. Translation: AAI05729.1.
BC107813 mRNA. Translation: AAI07814.1.
CCDSiCCDS41819.1. [Q32Q52-1]
CCDS53818.1. [Q32Q52-2]
RefSeqiNP_001032760.1. NM_001037671.3. [Q32Q52-1]
NP_001171568.1. NM_001178097.2. [Q32Q52-2]
UniGeneiHs.326303.

3D structure databases

ProteinModelPortaliQ32Q52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130800. 5 interactions.

PTM databases

iPTMnetiQ32Q52.

Polymorphism and mutation databases

BioMutaiC12orf74.

Proteomic databases

PaxDbiQ32Q52.
PRIDEiQ32Q52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397833; ENSP00000380933; ENSG00000214215. [Q32Q52-1]
ENST00000544406; ENSP00000446043; ENSG00000214215. [Q32Q52-2]
GeneIDi338809.
KEGGihsa:338809.
UCSCiuc001tch.3. human. [Q32Q52-1]

Organism-specific databases

CTDi338809.
GeneCardsiC12orf74.
HGNCiHGNC:27887. C12orf74.
HPAiHPA039294.
neXtProtiNX_Q32Q52.
PharmGKBiPA164716804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J05W. Eukaryota.
ENOG41116A6. LUCA.
GeneTreeiENSGT00430000032851.
HOGENOMiHOG000111775.
InParanoidiQ32Q52.
OMAiSRCVCIY.
OrthoDBiEOG73FQP6.
PhylomeDBiQ32Q52.
TreeFamiTF353652.

Miscellaneous databases

GenomeRNAii338809.
PROiQ32Q52.

Gene expression databases

BgeeiQ32Q52.
GenevisibleiQ32Q52. HS.

Family and domain databases

InterProiIPR031448. DUF4675.
[Graphical view]
PfamiPF15720. DUF4675. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiCL074_HUMAN
AccessioniPrimary (citable) accession number: Q32Q52
Secondary accession number(s): F5H4P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.