ID   Q32Q26_HUMAN            Unreviewed;       411 AA.
AC   Q32Q26;
DT   06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT   06-DEC-2005, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Anthrax toxin receptor {ECO:0000256|PIRNR:PIRNR038023};
GN   Name=ANTXR2 {ECO:0000313|EMBL:AAI07877.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI07877.1};
RN   [1] {ECO:0000313|EMBL:AAI07877.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:AAI07877.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095,
CC       ECO:0000256|PIRNR:PIRNR038023}.
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DR   EMBL; BC107876; AAI07877.1; -; mRNA.
DR   RefSeq; NP_001273709.1; NM_001286780.1.
DR   AlphaFoldDB; Q32Q26; -.
DR   PeptideAtlas; Q32Q26; -.
DR   DNASU; 118429; -.
DR   GeneID; 118429; -.
DR   CTD; 118429; -.
DR   OrthoDB; 5397560at2759; -.
DR   BioGRID-ORCS; 118429; 22 hits in 1163 CRISPR screens.
DR   ChiTaRS; ANTXR2; human.
DR   GenomeRNAi; 118429; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR017360; Anthrax_toxin_rcpt.
DR   InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR   InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR   PANTHER; PTHR16059:SF13; ANTHRAX TOXIN RECEPTOR 2; 1.
DR   Pfam; PF05586; Ant_C; 1.
DR   Pfam; PF05587; Anth_Ig; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PIRSF; PIRSF038023; Anthrax_toxin_receptor_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038023};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR038023,
KW   ECO:0000256|PIRSR:PIRSR038023-1};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|PIRNR:PIRNR038023};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        242..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..136
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          278..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         41
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
SQ   SEQUENCE   411 AA;  44839 MW;  372ED037ECEC054E CRC64;
     MRLSFIVFSS QATIILPLTG DRGKISKGLE DLKRVSPVGE TYIHEGLKLA NEQIQKAGGL
     KTSSIIIALT DGKLDGLVPS YAEKEAKISR SLGASVYCVG VLDFEQAQLE RIADSKEQVF
     PVKGGFQALK GIINSILAQS CTEILELQPS SVCVGEEFQI VLSGRGFMLG SRNGSVLCTY
     TVNETYTTSV KPVSVQLNSM LCPAPILNKA GETLDVSVSF NGGKSVISGS LIVTATECSN
     GIAAIIVILV LLLLLGIGLM WWFWPLCCKV VIKDPPPPPP PAPKEEEEEP LPTKKWPTVD
     ASYYGGQGVG GIKRMEVRWG DKGSTEEGAR LEKAKNAVVK IPEETEEPIR PRPPRPKPTH
     QPPQTKWYTP IKGRLDALWA LLRRQYDRVS LMRPQEGDEG RCINFSRVPS Q
//