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Protein

Nucleoside diphosphate kinase

Gene

NME1-NME2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Gene namesi
Name:NME1-NME2Imported
ORF Names:hCG_2001850Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000011052.21.
HGNCiHGNC:33531. NME1-NME2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000011052.

Expressioni

Gene expression databases

BgeeiENSG00000011052.

Interactioni

Protein-protein interaction databases

IntActiQ32Q12. 2 interactors.
MINTiMINT-5001342.
STRINGi9606.ENSP00000376889.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 139NDKInterPro annotationAdd BLAST110
Domaini145 – 278NDKInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
OMAiDGLVQYM.
OrthoDBiEOG091G0PLD.

Family and domain databases

Gene3Di3.30.70.141. 2 hits.
HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiView protein in InterPro
IPR034907. NDK-like_dom.
IPR036850. NDK-like_dom_sf.
IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
PfamiView protein in Pfam
PF00334. NDK. 2 hits.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 2 hits.
SUPFAMiSSF54919. SSF54919. 2 hits.
PROSITEiView protein in PROSITE
PS00469. NDP_KINASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32Q12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLSTLGIV FQGEGPPISS CDTGTMANCE RTFIAIKPDG VQRGLVGEII
60 70 80 90 100
KRFEQKGFRL VGLKFMQASE DLLKEHYVDL KDRPFFAGLV KYMHSGPVVA
110 120 130 140 150
MVWEGLNVVK TGRVMLGETN PADSKPGTIR GDFCIQVGRT MANLERTFIA
160 170 180 190 200
IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF
210 220 230 240 250
FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI
260 270 280 290
QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YE
Length:292
Mass (Da):32,642
Last modified:December 6, 2005 - v1
Checksum:i9D9E1393214E3CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005839 Genomic DNA. No translation available.
BC107894 mRNA. Translation: AAI07895.1.
CH471109 Genomic DNA. Translation: EAW94563.1.
UniGeneiHs.463456.

Genome annotation databases

EnsembliENST00000555572; ENSP00000451932; ENSG00000011052.
UCSCiuc002itk.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ32Q12_HUMAN
AccessioniPrimary (citable) accession number: Q32Q12
Entry historyiIntegrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported