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Protein

Protein unc-45 homolog A

Gene

Unc45a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).By similarityCurated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog A
Short name:
Unc-45A
Alternative name(s):
Smooth muscle cell-associated protein 1
Short name:
SMAP-1
Gene namesi
Name:Unc45a
Synonyms:Smap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305357. Unc45a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Protein unc-45 homolog APRO_0000249891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-acetyllysineBy similarity
Modified residuei483 – 4831N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ32PZ3.
PRIDEiQ32PZ3.

PTM databases

PhosphoSiteiQ32PZ3.

Expressioni

Gene expression databases

GenevisibleiQ32PZ3. RN.

Interactioni

Subunit structurei

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity).By similarity

Protein-protein interaction databases

BioGridi259130. 1 interaction.
STRINGi10116.ENSRNOP00000017407.

Structurei

3D structure databases

ProteinModelPortaliQ32PZ3.
SMRiQ32PZ3. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 5434TPR 1Add
BLAST
Repeati58 – 9134TPR 2Add
BLAST
Repeati92 – 12534TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00840000129775.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ32PZ3.
OMAiTFPGERI.
OrthoDBiEOG7VDXNH.
PhylomeDBiQ32PZ3.
TreeFamiTF314096.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
PF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32PZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSGPGTPE PRPSDPGASS AEELRKEGNE LFKCGDYEGA LTAYTQALSL
60 70 80 90 100
GATPQDQAIL HRNRAACHLK LEDYSKAESE ASKAIEKDGG DVKALYRRSQ
110 120 130 140 150
ALEKLGRLDQ AVLDLKRCVS LEPKNKVFQE SLRNIGGQIQ EKVRYMSSTD
160 170 180 190 200
AKVEQMFQIL LDPKEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL
210 220 230 240 250
QRLLDTGETD LMLAALRTLV GICSEHQSRT VATLSVLGTR RVVSILGVEN
260 270 280 290 300
QAVSLAACHL LQVMFDALKE GVKKGFRGKE GAIIVDPARE LKVLISNLLE
310 320 330 340 350
LLTEIGVSGQ GRDNALTLLI KMVPRKSPKD PNNSLTLWVI DQGLKKILEV
360 370 380 390 400
GGSVPEAAGE LTVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIR
410 420 430 440 450
SWFEGQGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASEQ
460 470 480 490 500
EEEQLVAVEA LIHAAGKAKR ASFITANGVA LLKDLYKGSE RDSIRIRALV
510 520 530 540 550
GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID AGTRRWAVEG
560 570 580 590 600
LAYLTFDADV KEEFVEDEAA LKALFQLSRS EERSVLFAVG SALVNCTNSY
610 620 630 640 650
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMTC
660 670 680 690 700
MVKTESPVLT NSCRELLSRV FLALVEEVED RGTVVAQGGG KALLPLALEG
710 720 730 740 750
TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLSCSGLQN
760 770 780 790 800
FEALMALTNL AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC
810 820 830 840 850
NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLRRAAAG GLAMLTSMRP
860 870 880 890 900
SLCSRIPQVT THWLEILQAL LLSPNPELQH RGTVVVLNMM ESSKEIASTL
910 920 930 940
MESEVLEILS VLAKGEESPV TRAAAACLEK AVEYRLIQPN QDGE
Length:944
Mass (Da):103,241
Last modified:December 6, 2005 - v1
Checksum:iD6F6CFB451E76952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107919 mRNA. Translation: AAI07920.1.
RefSeqiNP_001032736.1. NM_001037647.1.
UniGeneiRn.136574.

Genome annotation databases

EnsembliENSRNOT00000017407; ENSRNOP00000017407; ENSRNOG00000012357.
GeneIDi308759.
KEGGirno:308759.
UCSCiRGD:1305357. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107919 mRNA. Translation: AAI07920.1.
RefSeqiNP_001032736.1. NM_001037647.1.
UniGeneiRn.136574.

3D structure databases

ProteinModelPortaliQ32PZ3.
SMRiQ32PZ3. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259130. 1 interaction.
STRINGi10116.ENSRNOP00000017407.

PTM databases

PhosphoSiteiQ32PZ3.

Proteomic databases

PaxDbiQ32PZ3.
PRIDEiQ32PZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017407; ENSRNOP00000017407; ENSRNOG00000012357.
GeneIDi308759.
KEGGirno:308759.
UCSCiRGD:1305357. rat.

Organism-specific databases

CTDi55898.
RGDi1305357. Unc45a.

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00840000129775.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ32PZ3.
OMAiTFPGERI.
OrthoDBiEOG7VDXNH.
PhylomeDBiQ32PZ3.
TreeFamiTF314096.

Miscellaneous databases

NextBioi659476.
PROiQ32PZ3.

Gene expression databases

GenevisibleiQ32PZ3. RN.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
PF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUN45A_RAT
AccessioniPrimary (citable) accession number: Q32PZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 6, 2005
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.