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Protein

Lipase member H

Gene

Liph

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541NucleophileBy similarity
Active sitei178 – 1781Charge relay systemBy similarity
Active sitei248 – 2481Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERiratno-q6p6s8. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member H (EC:3.1.1.-)
Gene namesi
Name:Liph
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1592849. Liph.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 451435Lipase member HPRO_0000273324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi233 ↔ 246By similarity
Disulfide bondi270 ↔ 281By similarity
Disulfide bondi284 ↔ 292By similarity
Disulfide bondi427 ↔ 446By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ32PY2.
PRIDEiQ32PY2.

Structurei

3D structure databases

ProteinModelPortaliQ32PY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG080640.
InParanoidiQ32PY2.
KOiK19404.
PhylomeDBiQ32PY2.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32PY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLCFLLSF MCLVKSDTDE TCPSFTRLSF HSAVVGTGLS VRLMLYTQRD
60 70 80 90 100
QTCAQVINST ALGSLNVTKK TTFIIHGFRP TGSPPVWMEE LVQSLISVQE
110 120 130 140 150
MNVVVVDWNR GATTVIYPHA SSKTRKVALI LKEFIDQMLA KGASLDNIYM
160 170 180 190 200
IGVSLGAHIA GFVGEMYSGK LGRITGLDPA GPLFNGRPPE DRLDPSDAQF
210 220 230 240 250
VDVIHSDTDA LGYREALGHI DFYPNGGLDQ PGCPKTIFGG IKYFKCDHQM
260 270 280 290 300
SVFLYLASLQ NNCSITAYPC DSYRDYRNGK CVSCGAGHIV SCPSLGYYAD
310 320 330 340 350
NWREYLWDRD PPMTKAFFDT AETKPYCIYH YFVDIISWNK SVRRGFITIK
360 370 380 390 400
LRGEDGNITE SKIDHEPSAF QKYHQVSLLA RFNRDLDKVA EISLLFSTKS
410 420 430 440 450
VVGPKYKLRV LRMKLRSLAH PDRPHLCRYD LVLMENVETF FQPILCSKQQ

M
Length:451
Mass (Da):50,826
Last modified:December 6, 2005 - v1
Checksum:iE8EE38B33C348ACB
GO

Sequence cautioni

The sequence AAH62045 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031V → I in AAH62045 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062045 mRNA. Translation: AAH62045.1. Different initiation.
BC107932 mRNA. Translation: AAI07933.1.
RefSeqiNP_001037744.1. NM_001044279.1.
UniGeneiRn.200479.

Genome annotation databases

GeneIDi681694.
KEGGirno:681694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062045 mRNA. Translation: AAH62045.1. Different initiation.
BC107932 mRNA. Translation: AAI07933.1.
RefSeqiNP_001037744.1. NM_001044279.1.
UniGeneiRn.200479.

3D structure databases

ProteinModelPortaliQ32PY2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiratno-q6p6s8. Phospholipase.

Proteomic databases

PaxDbiQ32PY2.
PRIDEiQ32PY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi681694.
KEGGirno:681694.

Organism-specific databases

CTDi200879.
RGDi1592849. Liph.

Phylogenomic databases

HOVERGENiHBG080640.
InParanoidiQ32PY2.
KOiK19404.
PhylomeDBiQ32PY2.

Miscellaneous databases

PROiQ32PY2.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLIPH_RAT
AccessioniPrimary (citable) accession number: Q32PY2
Secondary accession number(s): Q6P6S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.