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Protein

Far upstream element-binding protein 1

Gene

Fubp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Far upstream element-binding protein 1By similarityImported
Short name:
FBPBy similarity
Short name:
FUSE-binding protein 1By similarity
Gene namesi
Name:Fubp1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1591892. Fubp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003651052 – 639Far upstream element-binding protein 1Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei148PhosphothreonineBy similarity1
Modified residuei316Omega-N-methylarginineBy similarity1
Modified residuei354Omega-N-methylarginineBy similarity1
Modified residuei356Omega-N-methylarginineBy similarity1
Modified residuei358Omega-N-methylarginineBy similarity1
Modified residuei427PhosphothreonineBy similarity1
Modified residuei625PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated. This targets the protein for proteasome-mediated degradation (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ32PX7.
PRIDEiQ32PX7.

PTM databases

iPTMnetiQ32PX7.
PhosphoSitePlusiQ32PX7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000043370.
GenevisibleiQ32PX7. RN.

Interactioni

Subunit structurei

Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061544.

Structurei

3D structure databases

ProteinModelPortaliQ32PX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 159KH 1PROSITE-ProRule annotationAdd BLAST65
Domaini180 – 246KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini270 – 334KH 3PROSITE-ProRule annotationAdd BLAST65
Domaini371 – 438KH 4PROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 22Poly-GlySequence analysis7
Compositional biasi445 – 555Pro-richSequence analysisAdd BLAST111

Sequence similaritiesi

Contains 4 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1676. Eukaryota.
ENOG410XZYE. LUCA.
HOVERGENiHBG000625.
InParanoidiQ32PX7.
KOiK13210.
OrthoDBiEOG091G073X.
PhylomeDBiQ32PX7.

Family and domain databases

Gene3Di3.30.1370.10. 4 hits.
InterProiIPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view]
SMARTiSM00322. KH. 4 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 4 hits.
PROSITEiPS50084. KH_TYPE_1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32PX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYSTVPPP SSGSAGGGGG GGVNDAFKDA LQRARQIAAK IGGDAGTSLN
60 70 80 90 100
SNDYGYGGQK RPLEDGDQPD AKKVPPQNDS FGAQLPPMHQ QQRSVMTEEY
110 120 130 140 150
KVPDGMVGFI IGRGGEQISR IQQESGCKIQ IAPDSGGLPE RSCMLTGTPE
160 170 180 190 200
SVQSAKRLLD QIVEKGRPAP GFHHGDGPGN AVQEIMIPAS KAGLVIGKGG
210 220 230 240 250
ETIKQLQERA GVKMVMIQDG PQNTGADKPL RITGDPYKVQ QAKEMVLELI
260 270 280 290 300
RDQGGFREVR NEYGSRIGGN EGIDVPIPRF AVGIVIGRNG EMIKKIQNDA
310 320 330 340 350
GVRIQFKPDD GTTPDRIAQI TGPPDRCQHA AEIITDLLRS VQAGNPGGPG
360 370 380 390 400
PGGRGRGRGQ GNWNMGPPGG LQEFNFIVPT GKTGLIIGKG GETIKSISQQ
410 420 430 440 450
SGARIELQRN PPPNADPNMK LFTIRGTPQQ IDYARQLIEE KIGGPVNPLG
460 470 480 490 500
PPVPHGPHGV PGPHGPPGPP GPGTPMGPYN PAPYNPGPPG PAPHGPPAPY
510 520 530 540 550
APQGWGNAYP HWQQQAPPDP AKAGTDPNSA AWAAYYAHYY QQQAQPPPAA
560 570 580 590 600
PAGAPTTTQT NGQGDQQNPA PAGQVDYTKA WEEYYKKMGQ AVPAPAGAPP
610 620 630
GGQPDYSAAW AEYYRQQAAY YAQTSPQGMP QHPPAPQGQ
Length:639
Mass (Da):67,197
Last modified:December 6, 2005 - v1
Checksum:i60ADA3F9BBC3314D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107942 mRNA. Translation: AAI07943.1.
RefSeqiNP_001032742.1. NM_001037653.1.
UniGeneiRn.177078.

Genome annotation databases

GeneIDi654496.
KEGGirno:654496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107942 mRNA. Translation: AAI07943.1.
RefSeqiNP_001032742.1. NM_001037653.1.
UniGeneiRn.177078.

3D structure databases

ProteinModelPortaliQ32PX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061544.

PTM databases

iPTMnetiQ32PX7.
PhosphoSitePlusiQ32PX7.

Proteomic databases

PaxDbiQ32PX7.
PRIDEiQ32PX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi654496.
KEGGirno:654496.

Organism-specific databases

CTDi8880.
RGDi1591892. Fubp1.

Phylogenomic databases

eggNOGiKOG1676. Eukaryota.
ENOG410XZYE. LUCA.
HOVERGENiHBG000625.
InParanoidiQ32PX7.
KOiK13210.
OrthoDBiEOG091G073X.
PhylomeDBiQ32PX7.

Miscellaneous databases

PROiQ32PX7.

Gene expression databases

BgeeiENSRNOG00000043370.
GenevisibleiQ32PX7. RN.

Family and domain databases

Gene3Di3.30.1370.10. 4 hits.
InterProiIPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view]
SMARTiSM00322. KH. 4 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 4 hits.
PROSITEiPS50084. KH_TYPE_1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUBP1_RAT
AccessioniPrimary (citable) accession number: Q32PX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.