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Protein

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Gene

Aimp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation, Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Alternative name(s):
Multisynthase complex auxiliary component p38
Protein JTV-1
Gene namesi
Name:Aimp2
Synonyms:Jtv1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1560787. Aimp2.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity

  • Note: Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.By similarity

GO - Cellular componenti

  • aminoacyl-tRNA synthetase multienzyme complex Source: CAFA
  • cytosol Source: UniProtKB-SubCell
  • membrane Source: Ensembl
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168421 – 320Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues in response to UV irradiation.By similarity
Ubiquitinated by PRKN, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ32PX2.
PRIDEiQ32PX2.

PTM databases

iPTMnetiQ32PX2.
PhosphoSitePlusiQ32PX2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001044.
ExpressionAtlasiQ32PX2. baseline and differential.
GenevisibleiQ32PX2. RN.

Interactioni

Subunit structurei

Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PRKN/parkin (via first RING-type domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001379.

Structurei

3D structure databases

ProteinModelPortaliQ32PX2.
SMRiQ32PX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 317GST C-terminalAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 162Interaction with PRKNBy similarityAdd BLAST81
Regioni162 – 225Interaction with TP53By similarityAdd BLAST64

Phylogenomic databases

eggNOGiENOG410II5D. Eukaryota.
ENOG4110B04. LUCA.
GeneTreeiENSGT00390000015826.
HOGENOMiHOG000015282.
InParanoidiQ32PX2.
KOiK15438.
OMAiRVELPTC.
OrthoDBiEOG091G0Q05.
PhylomeDBiQ32PX2.
TreeFamiTF326322.

Family and domain databases

InterProiView protein in InterPro
IPR031889. AIMP2_LysRS-bd.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
PfamiView protein in Pfam
PF16780. AIMP2_LysRS_bd. 1 hit.
PF00043. GST_C. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32PX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMYQVKPYH GGSAPLRVEL PTCMYRLPNV HSKTTSPATD AGHVQEPSEP
60 70 80 90 100
SLRALESRQD DILKRLYELK AAVDGLSKMI HTPDADLDVT NILQADEPTT
110 120 130 140 150
LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCERYRVLS
160 170 180 190 200
TVHTHSSVKN VPENLLKCFG EQARKQSRHE YQLGFTLIWK NVPKTQMKFS
210 220 230 240 250
VQTMCPIEGE GNIARFLFSL FGQKHNAVHL TLIDSWVDIA MFQLREGSSK
260 270 280 290 300
EKAAVFRSMN SALGKSPWLV GNELTVADVV LWSVLQQTGG SSGAAPTNVQ
310 320
RWLKSCENLA PFSTALQLLK
Length:320
Mass (Da):35,443
Last modified:December 6, 2005 - v1
Checksum:iC21D0BB7ACDF3141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107947 mRNA. Translation: AAI07948.1.
RefSeqiNP_001032425.1. NM_001037348.1.
UniGeneiRn.162097.

Genome annotation databases

EnsembliENSRNOT00000001379; ENSRNOP00000001379; ENSRNOG00000001044.
GeneIDi288480.
KEGGirno:288480.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAIMP2_RAT
AccessioniPrimary (citable) accession number: Q32PX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome