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Protein

AP-3 complex subunit beta-1

Gene

AP3B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta-1
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-1
Adaptor-related protein complex 3 subunit beta-1
Beta-3A-adaptin
Clathrin assembly protein complex 3 beta-1 large chain
Gene namesi
Name:AP3B1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10841084AP-3 complex subunit beta-1PRO_0000283801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei609 – 6091PhosphoserineBy similarity
Modified residuei742 – 7421PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ32PG1.
PRIDEiQ32PG1.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006605.

Structurei

3D structure databases

ProteinModelPortaliQ32PG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi677 – 792116Glu/Ser-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1060. Eukaryota.
COG5096. LUCA.
GeneTreeiENSGT00530000063546.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ32PG1.
KOiK12397.
OMAiFVPMKTH.
OrthoDBiEOG74R1QG.
TreeFamiTF314605.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026740. AP3_beta.
IPR029394. AP3B1_Ser.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015151. B-adaptin_app_sub_C.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 2 hits.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
PF14797. SEEEED. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SMARTiSM01355. AP3B1_C. 1 hit.
SM01020. B2-adapt-app_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q32PG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSFAYNE QSGGGEATEL GQEATSTISP SGAFGLFSSD MKKNEDLKQM
60 70 80 90 100
LESNKDSAKL DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV
110 120 130 140 150
YLVRYAEEQQ DLALLSISTF QRALKDPNQL IRASALRVLS SIRVPIIVPI
160 170 180 190 200
MMLAIKEASA DLSPYVRKNA AHAIQKLYSL DPEQKEMLIE IIEKLLKDKS
210 220 230 240 250
TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG QVVIIHMLTR
260 270 280 290 300
YARTQFVSPW RQGDVLEDNE KDFYDSDEEQ KEKADKRKRP YAMDPDHRLL
310 320 330 340 350
IRNTKPLLQS RNAAVVMAVA QLYWHIAPKS EAGIISKSLV RLLRSSREVQ
360 370 380 390 400
YIVLQNIATM SIQRKGMFEP YLKSFYVRST DATMIKILKL EILTNLANEA
410 420 430 440 450
NISTLLREFQ TYVKSQDKQF AAATIQTIGR CATSITEVSD TCLNGLVCLL
460 470 480 490 500
SNRDEIVVAE SVVVIKKLLQ MQPMQHGEII KHMAKLLDSI TVPVARASIL
510 520 530 540 550
WLIGENCERV PKIAPDVLRK TAKSFTSEDD LVKLQILNLG AKLYLTNSKQ
560 570 580 590 600
TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNEKSGAL SKYAKKIFLA
610 620 630 640 650
QKPAPLLESP FKDRDHFQLG TLSHTLNTKA TGYLELSNWP EVAPDPSVRN
660 670 680 690 700
VEVIELAKEW TPAGKAKKEN PDKKFYSESE EEEDSSESSS DSESESGSES
710 720 730 740 750
GEDEEDDRSG DSAEDSGESG SEPEAGKGRA ATRSRARGRG DSKDVDKEKE
760 770 780 790 800
NSKTSESSSG ESSSIEESSS DSESESESES ESESRKVTKE KEKKTKQERN
810 820 830 840 850
PLTKDVSLLD LDDFNLVSTP VALPTPALSP SLIADLEGLN LSATSSVISV
860 870 880 890 900
STPVFVPGKT HVLLHRMSGK GLAAHYFFPR QPCIFGDKMV SVQITLNNTT
910 920 930 940 950
DQKIENIHVG GKKLPMGMQM HVFNPIESLE PAGSITVSMG IDFCDSTQTA
960 970 980 990 1000
SFQLCTKDDC FSVNIQPPVG ELLLPVAMSE KDFKKEQGML SGMNETSTTI
1010 1020 1030 1040 1050
IAAPQNFASS VILQKIVNVA NVGVVPSGQD NIHRFAAKTV HSGSLMLVTV
1060 1070 1080
ELKEGSTAQL IINTEKTVIG SVLLRELKPV LSQG
Length:1,084
Mass (Da):119,968
Last modified:December 6, 2005 - v1
Checksum:i4B694C02E3F3C636
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108129 mRNA. Translation: AAI08130.1.
RefSeqiNP_001070002.1. NM_001076534.1.
UniGeneiBt.8350.

Genome annotation databases

EnsembliENSBTAT00000006605; ENSBTAP00000006605; ENSBTAG00000005016.
GeneIDi767602.
KEGGibta:767602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108129 mRNA. Translation: AAI08130.1.
RefSeqiNP_001070002.1. NM_001076534.1.
UniGeneiBt.8350.

3D structure databases

ProteinModelPortaliQ32PG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006605.

Proteomic databases

PaxDbiQ32PG1.
PRIDEiQ32PG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006605; ENSBTAP00000006605; ENSBTAG00000005016.
GeneIDi767602.
KEGGibta:767602.

Organism-specific databases

CTDi8546.

Phylogenomic databases

eggNOGiKOG1060. Eukaryota.
COG5096. LUCA.
GeneTreeiENSGT00530000063546.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ32PG1.
KOiK12397.
OMAiFVPMKTH.
OrthoDBiEOG74R1QG.
TreeFamiTF314605.

Enzyme and pathway databases

ReactomeiR-BTA-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

NextBioi20918018.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026740. AP3_beta.
IPR029394. AP3B1_Ser.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015151. B-adaptin_app_sub_C.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 2 hits.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
PF14797. SEEEED. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SMARTiSM01355. AP3B1_C. 1 hit.
SM01020. B2-adapt-app_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiAP3B1_BOVIN
AccessioniPrimary (citable) accession number: Q32PG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 6, 2005
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.