Q32PD6 (LYZL5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sperm acrosome-associated protein 5
EC=3.2.1.17

Alternative name(s):
Lysozyme-like protein 5

Gene names

Name:	SPACA5
Synonyms:	LYZL5

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 156	138	Sperm acrosome-associated protein 5		PRO_0000284469
Sites
	Active site	53	1	By similarity
Amino acid modifications
	Disulfide bond	24 ↔ 144		By similarity
	Disulfide bond	48 ↔ 132		By similarity
	Disulfide bond	82 ↔ 97		By similarity
	Disulfide bond	93 ↔ 111		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q32PD6 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 427670D8003EA25E	FASTA	156	17,580
	10 20 30 40 50 60 MQVSGTIVVI LMAANVEAKI YERCDLAKKL EAAGLNGFKG YTIGDWLCMA HYESGFDTSF 70 80 90 100 110 120 VNHNPDGSSE YGIFQLNSAW WCYNGVTPSE NLCHMDCHEL LNRHILDDIM CAKKVVSSES 130 140 150 GMSAWDSWNQ HCYGYDLSEW LRGCHMNAKP NKKIIS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC108157 mRNA. Translation: AAI08158.1.
IPI	IPI00760484.
RefSeq	NP_001035626.1. NM_001040536.2.
UniGene	Bt.50571.
3D structure databases
HSSP	HSSP built from PDB template 2CWI based on UniProtKB P81708.
ProteinModelPortal	Q32PD6.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000063388; ENSBTAP00000055963; ENSBTAG00000046069.
GeneID	517880.
KEGG	bta:517880.
Organism-specific databases
CTD	389852.
Phylogenomic databases
GeneTree	ENSGT00550000074398.
HOVERGEN	HBG052297.
KO	K01185.
OMA	IGDWLCM.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. False negative. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20872529.

Entry information

Entry name

LYZL5_BOVIN

Accession

Primary (citable) accession number: Q32PD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	December 6, 2005
Last modified:	October 31, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program