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Protein

ADP-ribosylation factor-like protein 2-binding protein

Gene

ARL2BP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 2-binding protein
Short name:
ARF-like 2-binding protein
Alternative name(s):
Binder of ARF2 protein 1
Gene namesi
Name:ARL2BP
Synonyms:BART1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:26142 ARL2BP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871121 – 163ADP-ribosylation factor-like protein 2-binding proteinAdd BLAST163

Proteomic databases

PaxDbiQ32PC9
PRIDEiQ32PC9

Expressioni

Tissue specificityi

Expressed in brain.2 Publications

Gene expression databases

BgeeiENSBTAG00000004844

Interactioni

Subunit structurei

Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for targeting to cilia basal body (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4. Found in a complex with ARL2BP, ARL2 and SLC25A6.By similarity2 Publications

Protein-protein interaction databases

BioGridi541183, 1 interactor
STRINGi9913.ENSBTAP00000006363

Structurei

3D structure databases

ProteinModelPortaliQ32PC9
SMRiQ32PC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL2BP family.Curated

Phylogenomic databases

eggNOGiENOG410IKTQ Eukaryota
ENOG4111IGT LUCA
GeneTreeiENSGT00390000015052
HOGENOMiHOG000024955
HOVERGENiHBG105565
InParanoidiQ32PC9
KOiK16742
OMAiQQHKDEM
OrthoDBiEOG091G09PN
TreeFamiTF315143

Family and domain databases

InterProiView protein in InterPro
IPR023379 ARF-like_2-bdp_dom
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32PC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALEEESFA LSFSSASDAE FDAVVGYLED IIMDDEFQLL QRNFMDKYYQ
60 70 80 90 100
EFEDTEENKL TYTPIFNEYI SLVEKYIEEQ LLERIPGFNM AAFTTTLQHH
110 120 130 140 150
KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK
160
SSSVPASQNN LRP
Length:163
Mass (Da):18,772
Last modified:May 15, 2007 - v2
Checksum:iB4E2678AC0383EA7
GO
Isoform 2 (identifier: Q32PC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MDALEEESFALSF → MR

Show »
Length:152
Mass (Da):17,589
Checksum:i574F06E544ED02AA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253161 – 13MDALE…FALSF → MR in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108166 mRNA Translation: AAI08167.1
BC134728 mRNA Translation: AAI34729.1
RefSeqiNP_001069742.2, NM_001076274.2 [Q32PC9-1]
UniGeneiBt.11667

Genome annotation databases

EnsembliENSBTAT00000006363; ENSBTAP00000006363; ENSBTAG00000004844 [Q32PC9-1]
ENSBTAT00000046263; ENSBTAP00000043580; ENSBTAG00000004844 [Q32PC9-2]
GeneIDi613462
KEGGibta:613462

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAR2BP_BOVIN
AccessioniPrimary (citable) accession number: Q32PC9
Secondary accession number(s): A4IFR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: March 28, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health