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Protein

ADP-ribosylation factor-like protein 2-binding protein

Gene

ARL2BP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 2-binding protein
Short name:
ARF-like 2-binding protein
Alternative name(s):
Binder of ARF2 protein 1
Gene namesi
Name:ARL2BP
Synonyms:BART1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: Ensembl
  • cilium Source: UniProtKB-KW
  • midbody Source: Ensembl
  • mitochondrial intermembrane space Source: UniProtKB-SubCell
  • mitochondrion Source: AgBase
  • nucleus Source: UniProtKB-SubCell
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871121 – 163ADP-ribosylation factor-like protein 2-binding proteinAdd BLAST163

Proteomic databases

PaxDbiQ32PC9.
PRIDEiQ32PC9.

Expressioni

Tissue specificityi

Expressed in brain.2 Publications

Gene expression databases

BgeeiENSBTAG00000004844.

Interactioni

Subunit structurei

Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for targeting to cilia basal body (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4. Found in a complex with ARL2BP, ARL2 and SLC25A6.By similarity2 Publications

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006363.

Structurei

3D structure databases

ProteinModelPortaliQ32PC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL2BP family.Curated

Phylogenomic databases

eggNOGiENOG410IKTQ. Eukaryota.
ENOG4111IGT. LUCA.
GeneTreeiENSGT00390000015052.
HOGENOMiHOG000024955.
HOVERGENiHBG105565.
InParanoidiQ32PC9.
KOiK16742.
OMAiFMAFKEM.
OrthoDBiEOG091G09PN.
TreeFamiTF315143.

Family and domain databases

Gene3Di1.20.1520.10. 1 hit.
InterProiIPR023379. ARF-like_2-bdp_dom.
[Graphical view]
PfamiPF11527. ARL2_Bind_BART. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32PC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALEEESFA LSFSSASDAE FDAVVGYLED IIMDDEFQLL QRNFMDKYYQ
60 70 80 90 100
EFEDTEENKL TYTPIFNEYI SLVEKYIEEQ LLERIPGFNM AAFTTTLQHH
110 120 130 140 150
KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK
160
SSSVPASQNN LRP
Length:163
Mass (Da):18,772
Last modified:May 15, 2007 - v2
Checksum:iB4E2678AC0383EA7
GO
Isoform 2 (identifier: Q32PC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MDALEEESFALSF → MR

Show »
Length:152
Mass (Da):17,589
Checksum:i574F06E544ED02AA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253161 – 13MDALE…FALSF → MR in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108166 mRNA. Translation: AAI08167.1.
BC134728 mRNA. Translation: AAI34729.1.
RefSeqiNP_001069742.2. NM_001076274.2. [Q32PC9-1]
UniGeneiBt.11667.

Genome annotation databases

EnsembliENSBTAT00000006363; ENSBTAP00000006363; ENSBTAG00000004844. [Q32PC9-1]
ENSBTAT00000046263; ENSBTAP00000043580; ENSBTAG00000004844. [Q32PC9-2]
GeneIDi613462.
KEGGibta:613462.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108166 mRNA. Translation: AAI08167.1.
BC134728 mRNA. Translation: AAI34729.1.
RefSeqiNP_001069742.2. NM_001076274.2. [Q32PC9-1]
UniGeneiBt.11667.

3D structure databases

ProteinModelPortaliQ32PC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006363.

Proteomic databases

PaxDbiQ32PC9.
PRIDEiQ32PC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006363; ENSBTAP00000006363; ENSBTAG00000004844. [Q32PC9-1]
ENSBTAT00000046263; ENSBTAP00000043580; ENSBTAG00000004844. [Q32PC9-2]
GeneIDi613462.
KEGGibta:613462.

Organism-specific databases

CTDi23568.

Phylogenomic databases

eggNOGiENOG410IKTQ. Eukaryota.
ENOG4111IGT. LUCA.
GeneTreeiENSGT00390000015052.
HOGENOMiHOG000024955.
HOVERGENiHBG105565.
InParanoidiQ32PC9.
KOiK16742.
OMAiFMAFKEM.
OrthoDBiEOG091G09PN.
TreeFamiTF315143.

Enzyme and pathway databases

ReactomeiR-BTA-422356. Regulation of insulin secretion.

Gene expression databases

BgeeiENSBTAG00000004844.

Family and domain databases

Gene3Di1.20.1520.10. 1 hit.
InterProiIPR023379. ARF-like_2-bdp_dom.
[Graphical view]
PfamiPF11527. ARL2_Bind_BART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAR2BP_BOVIN
AccessioniPrimary (citable) accession number: Q32PC9
Secondary accession number(s): A4IFR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 5, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.