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Protein

Heterogeneous nuclear ribonucleoprotein A1-like 2

Gene

HNRNPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1-like 2
Short name:
hnRNP A1-like 2
Alternative name(s):
hnRNP core protein A1-like 2
Gene namesi
Name:HNRNPA1L2
Synonyms:HNRNPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:27067. HNRNPA1L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720701.

Polymorphism and mutation databases

BioMutaiHNRNPA1L2.
DMDMi190356061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 320319Heterogeneous nuclear ribonucleoprotein A1-like 2PRO_0000318848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei194 – 1941Asymmetric dimethylarginineBy similarity
Modified residuei206 – 2061Asymmetric dimethylarginineBy similarity
Modified residuei218 – 2181Asymmetric dimethylarginineBy similarity
Modified residuei225 – 2251Asymmetric dimethylarginineBy similarity
Modified residuei298 – 2981N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ32P51.
MaxQBiQ32P51.
PaxDbiQ32P51.
PeptideAtlasiQ32P51.
PRIDEiQ32P51.

PTM databases

iPTMnetiQ32P51.
PhosphoSiteiQ32P51.
SwissPalmiQ32P51.

Expressioni

Gene expression databases

BgeeiQ32P51.
ExpressionAtlasiQ32P51. baseline and differential.
GenevisibleiQ32P51. HS.

Interactioni

Protein-protein interaction databases

BioGridi126887. 27 interactions.
IntActiQ32P51. 20 interactions.
STRINGi9606.ENSP00000341285.

Structurei

3D structure databases

ProteinModelPortaliQ32P51.
SMRiQ32P51. Positions 8-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9784RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 18480RRM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 9491Globular A domainAdd
BLAST
Regioni95 – 18591Globular B domainAdd
BLAST
Regioni218 – 24023RNA-binding RGG-boxAdd
BLAST
Regioni268 – 30538Nuclear targeting sequenceBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 317123Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
InParanoidiQ32P51.
KOiK12741.
OMAiYFQHFGN.
OrthoDBiEOG715Q6V.
PhylomeDBiQ32P51.
TreeFamiTF351342.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR021662. HnRNPA1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF11627. HnRNPA1. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32P51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSASPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
60 70 80 90 100
TKRSRGFGFV TYATVEEVDA AMNTTPHKVD GRVVEPKRAV SREDSQRPGA
110 120 130 140 150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
160 170 180 190 200
VTFDDHDSVD KIVIQKYHTV KGHNCEVRKA LPKQEMASAS SSQRGRRGSG
210 220 230 240 250
NFGGGRGDGF GGNDNFGRGG NFSGRGGFGG SCGGGGYGGS GDGYNGFGND
260 270 280 290 300
GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPQ
310 320
NQGGYGVSSS SSSYGSGRRF
Length:320
Mass (Da):34,225
Last modified:February 26, 2008 - v2
Checksum:i002EE1547DAC04A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891Y → C in AAI08267 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151N → D.
Corresponds to variant rs9536212 [ dbSNP | Ensembl ].
VAR_038904

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123159 mRNA. No translation available.
AL137058 Genomic DNA. Translation: CAI16736.1.
CH471124 Genomic DNA. Translation: EAW52041.1.
BC108266 mRNA. Translation: AAI08267.1.
CCDSiCCDS31980.1.
RefSeqiNP_001011724.1. NM_001011724.1.
NP_001011725.1. NM_001011725.1.
UniGeneiHs.447506.

Genome annotation databases

EnsembliENST00000357495; ENSP00000350090; ENSG00000139675.
GeneIDi144983.
KEGGihsa:144983.
UCSCiuc021rjy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123159 mRNA. No translation available.
AL137058 Genomic DNA. Translation: CAI16736.1.
CH471124 Genomic DNA. Translation: EAW52041.1.
BC108266 mRNA. Translation: AAI08267.1.
CCDSiCCDS31980.1.
RefSeqiNP_001011724.1. NM_001011724.1.
NP_001011725.1. NM_001011725.1.
UniGeneiHs.447506.

3D structure databases

ProteinModelPortaliQ32P51.
SMRiQ32P51. Positions 8-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126887. 27 interactions.
IntActiQ32P51. 20 interactions.
STRINGi9606.ENSP00000341285.

PTM databases

iPTMnetiQ32P51.
PhosphoSiteiQ32P51.
SwissPalmiQ32P51.

Polymorphism and mutation databases

BioMutaiHNRNPA1L2.
DMDMi190356061.

Proteomic databases

EPDiQ32P51.
MaxQBiQ32P51.
PaxDbiQ32P51.
PeptideAtlasiQ32P51.
PRIDEiQ32P51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357495; ENSP00000350090; ENSG00000139675.
GeneIDi144983.
KEGGihsa:144983.
UCSCiuc021rjy.3. human.

Organism-specific databases

CTDi144983.
GeneCardsiHNRNPA1L2.
HGNCiHGNC:27067. HNRNPA1L2.
neXtProtiNX_Q32P51.
PharmGKBiPA164720701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
InParanoidiQ32P51.
KOiK12741.
OMAiYFQHFGN.
OrthoDBiEOG715Q6V.
PhylomeDBiQ32P51.
TreeFamiTF351342.

Miscellaneous databases

GenomeRNAii144983.
PROiQ32P51.

Gene expression databases

BgeeiQ32P51.
ExpressionAtlasiQ32P51. baseline and differential.
GenevisibleiQ32P51. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR021662. HnRNPA1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF11627. HnRNPA1. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiRA1L2_HUMAN
AccessioniPrimary (citable) accession number: Q32P51
Secondary accession number(s): Q5TBS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.