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Protein

Heterogeneous nuclear ribonucleoprotein A1-like 2

Gene

HNRNPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1-like 2
Short name:
hnRNP A1-like 2
Alternative name(s):
hnRNP core protein A1-like 2
Gene namesi
Name:HNRNPA1L2
Synonyms:HNRNPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:27067. HNRNPA1L2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720701.

Polymorphism and mutation databases

BioMutaiHNRNPA1L2.
DMDMi190356061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188481 – 320Heterogeneous nuclear ribonucleoprotein A1-like 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei194Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei194Omega-N-methylarginine; alternateBy similarity1
Modified residuei206Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei206Omega-N-methylarginine; alternateBy similarity1
Modified residuei218Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei218Omega-N-methylarginine; alternateBy similarity1
Modified residuei225Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei225Omega-N-methylarginine; alternateBy similarity1
Modified residuei284Omega-N-methylarginineBy similarity1
Modified residuei298N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ32P51.
MaxQBiQ32P51.
PaxDbiQ32P51.
PeptideAtlasiQ32P51.
PRIDEiQ32P51.

PTM databases

iPTMnetiQ32P51.
PhosphoSitePlusiQ32P51.
SwissPalmiQ32P51.

Expressioni

Gene expression databases

BgeeiENSG00000139675.
ExpressionAtlasiQ32P51. baseline and differential.
GenevisibleiQ32P51. HS.

Interactioni

Protein-protein interaction databases

BioGridi126887. 27 interactors.
IntActiQ32P51. 21 interactors.
STRINGi9606.ENSP00000341285.

Structurei

3D structure databases

ProteinModelPortaliQ32P51.
SMRiQ32P51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 97RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini105 – 184RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 94Globular A domainAdd BLAST91
Regioni95 – 185Globular B domainAdd BLAST91
Regioni218 – 240RNA-binding RGG-boxAdd BLAST23
Regioni268 – 305Nuclear targeting sequenceBy similarityAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 317Gly-richAdd BLAST123

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
InParanoidiQ32P51.
KOiK12741.
OMAiKGHNCEV.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ32P51.
TreeFamiTF351342.

Family and domain databases

CDDicd12580. RRM2_hnRNPA1. 1 hit.
InterProiView protein in InterPro
IPR021662. HnRNPA1.
IPR034803. hnRNPA1_RRM2.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF11627. HnRNPA1. 1 hit.
PF00076. RRM_1. 2 hits.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 2 hits.

Sequencei

Sequence statusi: Complete.

Q32P51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSASPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
60 70 80 90 100
TKRSRGFGFV TYATVEEVDA AMNTTPHKVD GRVVEPKRAV SREDSQRPGA
110 120 130 140 150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
160 170 180 190 200
VTFDDHDSVD KIVIQKYHTV KGHNCEVRKA LPKQEMASAS SSQRGRRGSG
210 220 230 240 250
NFGGGRGDGF GGNDNFGRGG NFSGRGGFGG SCGGGGYGGS GDGYNGFGND
260 270 280 290 300
GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPQ
310 320
NQGGYGVSSS SSSYGSGRRF
Length:320
Mass (Da):34,225
Last modified:February 26, 2008 - v2
Checksum:i002EE1547DAC04A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289Y → C in AAI08267 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038904215N → D. Corresponds to variant dbSNP:rs9536212Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123159 mRNA. No translation available.
AL137058 Genomic DNA. No translation available.
CH471124 Genomic DNA. Translation: EAW52041.1.
BC108266 mRNA. Translation: AAI08267.1.
CCDSiCCDS31980.1.
RefSeqiNP_001011724.1. NM_001011724.1.
NP_001011725.1. NM_001011725.1.
UniGeneiHs.447506.

Genome annotation databases

EnsembliENST00000357495; ENSP00000350090; ENSG00000139675.
GeneIDi144983.
KEGGihsa:144983.
UCSCiuc021rjy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRA1L2_HUMAN
AccessioniPrimary (citable) accession number: Q32P51
Secondary accession number(s): Q5TBS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations