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Protein

Transmembrane channel-like protein 5

Gene

Tmc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 5
Gene namesi
Name:Tmc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1921674. Tmc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 420420ExtracellularSequence analysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence analysisAdd
BLAST
Topological domaini442 – 4498CytoplasmicSequence analysis
Transmembranei450 – 47021HelicalSequence analysisAdd
BLAST
Topological domaini471 – 48717ExtracellularSequence analysisAdd
BLAST
Transmembranei488 – 50821HelicalSequence analysisAdd
BLAST
Topological domaini509 – 58173CytoplasmicSequence analysisAdd
BLAST
Transmembranei582 – 60221HelicalSequence analysisAdd
BLAST
Topological domaini603 – 61614ExtracellularSequence analysisAdd
BLAST
Transmembranei617 – 63721HelicalSequence analysisAdd
BLAST
Topological domaini638 – 66023CytoplasmicSequence analysisAdd
BLAST
Transmembranei661 – 68121HelicalSequence analysisAdd
BLAST
Topological domaini682 – 69413ExtracellularSequence analysisAdd
BLAST
Transmembranei695 – 71521HelicalSequence analysisAdd
BLAST
Topological domaini716 – 74934CytoplasmicSequence analysisAdd
BLAST
Transmembranei750 – 77021HelicalSequence analysisAdd
BLAST
Topological domaini771 – 79626ExtracellularSequence analysisAdd
BLAST
Transmembranei797 – 81721HelicalSequence analysisAdd
BLAST
Topological domaini818 – 86144CytoplasmicSequence analysisAdd
BLAST
Transmembranei862 – 88221HelicalSequence analysisAdd
BLAST
Topological domaini883 – 96785ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Transmembrane channel-like protein 5PRO_0000289967Add
BLAST

Proteomic databases

MaxQBiQ32NZ6.
PaxDbiQ32NZ6.
PRIDEiQ32NZ6.

PTM databases

iPTMnetiQ32NZ6.
PhosphoSiteiQ32NZ6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ32NZ6.
CleanExiMM_TMC5.
ExpressionAtlasiQ32NZ6. baseline and differential.
GenevisibleiQ32NZ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095694.

Structurei

3D structure databases

ProteinModelPortaliQ32NZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH09. Eukaryota.
ENOG410XR0Y. LUCA.
GeneTreeiENSGT00760000119171.
HOGENOMiHOG000154633.
HOVERGENiHBG108587.
InParanoidiQ32NZ6.
OMAiHAYFLTI.
OrthoDBiEOG7D85XD.
PhylomeDBiQ32NZ6.
TreeFamiTF313462.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32NZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSFHQNSSY MEDADYPGYS GSRNHTHNYL ETQDYPEFPG SQNNPGFHHP
60 70 80 90 100
RSNPHSSGSR TNPDYPYFQE EPDYPGSLSN TVYQDTRSHP FSAHSRTRPD
110 120 130 140 150
YESSIEPDYN DFRSESYHAG LPMEPDYPGS QSHPGFAGVG RSSMNYTGPR
160 170 180 190 200
TNLGYLGSLE EPDYPGAQDN SYYHSGSRPH SNLPGSRRDA GYAGSRINSY
210 220 230 240 250
PDDLGEPDYP GAENQPNSPR FYGKPDYPGA EEGDGYSSSK SLAVIRRGNG
260 270 280 290 300
PFGMLGRRNE DYPEGIGMVS MEMAGDPRNG YVNPAYTRRI SPVCPDRNLL
310 320 330 340 350
LCAHDWHTSV QGQKLIASLI PMTTRDRIKT IRNQPRTMQE KRELRKIVDK
360 370 380 390 400
EKNKQSHGIL EANCCAQCLG SLSLTYRRTR NGLSELLNYI TLWQKRFKVI
410 420 430 440 450
GGKFGTSVLS YFSFLRWLLK FNIFSFVMNF SFIIIPQFTV GAKNTLQFTG
460 470 480 490 500
LEFFTGAGYF GDTVMYYGFY TNSTIRHRMG GASYNMQLAY IFTIGACLVV
510 520 530 540 550
CFFSLLFSMA KYFRNNFINP HIYSRGIAKL IFCWDFTVTH EKAVKLKQKN
560 570 580 590 600
LSTEIRENLS ELRQENYRLT FNQQLTRFSA HVAAWLVSTG VTAACCVAVY
610 620 630 640 650
YLAEYNSEFL KTHRNPGAVL LLPFVVSCIN LAVPRFYSMF RLVERYEIPR
660 670 680 690 700
QEVYVLLVRN IFLKISIVGI LCYYWLNIVA LSGEECWETL IGQDIYRLLL
710 720 730 740 750
MDFVFSLADS LLGEFLRRLI GMKFTSLSLQ EFDIARNVLE LIYAQTLTWL
760 770 780 790 800
GIFFCPLLPF IQMITLFIMF YVKNVSLMMN FQPPSKAWRA SQMITFFIFL
810 820 830 840 850
LFFPSFTGVL CTLAITIWRL KPSADCGPFR GLPSFIQSIY SWIDTLSRRP
860 870 880 890 900
GYLWVVWIYQ NLIGSVHFFF ILTLIVLIIT YLYWQITEGR KVMIRLLHEQ
910 920 930 940 950
IINEGKDKMF LIEKLTKLQD MEKRVNPSAL DLERREVEPQ IPLHLEELGA
960
APDLRLRRSA QEENPIA
Length:967
Mass (Da):111,070
Last modified:December 6, 2005 - v1
Checksum:i92B5BE50F69F3CC4
GO
Isoform 2 (identifier: Q32NZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: Missing.
     211-309: GAENQPNSPR...LLCAHDWHTS → MQSDDQVDEI...TDESCTFHET

Show »
Length:757
Mass (Da):87,667
Checksum:i320D61A71CF51DAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti527 – 5271I → V in AAP69873 (PubMed:12812529).Curated
Sequence conflicti658 – 6581V → I in AAP69873 (PubMed:12812529).Curated
Sequence conflicti658 – 6581V → I in AAH46390 (PubMed:15489334).Curated
Sequence conflicti793 – 7931M → V in AAP69873 (PubMed:12812529).Curated
Sequence conflicti926 – 9261N → D in AAP69873 (PubMed:12812529).Curated
Sequence conflicti947 – 9471E → D in AAH46390 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 210210Missing in isoform 2. 3 PublicationsVSP_026047Add
BLAST
Alternative sequencei211 – 30999GAENQ…DWHTS → MQSDDQVDEIIIEVENVPSG VQNHLVSSQIALRKSSANPA FCVLSSSAADRVDCQIFNPG NDRRHNRLLRFSSLNESISQ IYHGSECLVTDESCTFHET in isoform 2. 3 PublicationsVSP_026048Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236495 mRNA. Translation: AAP69873.1.
AK016573 mRNA. Translation: BAB30314.1.
AY263159 mRNA. Translation: AAP78774.1.
BC046390 mRNA. Translation: AAH46390.1.
BC108382 mRNA. Translation: AAI08383.1.
CCDSiCCDS21773.1. [Q32NZ6-2]
CCDS52374.1. [Q32NZ6-1]
RefSeqiNP_001098722.1. NM_001105252.1. [Q32NZ6-1]
NP_083206.1. NM_028930.3. [Q32NZ6-2]
XP_011240225.1. XM_011241923.1. [Q32NZ6-1]
XP_011240226.1. XM_011241924.1. [Q32NZ6-1]
XP_011240227.1. XM_011241925.1. [Q32NZ6-1]
UniGeneiMm.11068.

Genome annotation databases

EnsembliENSMUST00000057320; ENSMUSP00000049784; ENSMUSG00000030650. [Q32NZ6-2]
ENSMUST00000098088; ENSMUSP00000095694; ENSMUSG00000030650. [Q32NZ6-1]
ENSMUST00000121715; ENSMUSP00000112434; ENSMUSG00000030650. [Q32NZ6-1]
ENSMUST00000121744; ENSMUSP00000114137; ENSMUSG00000030650. [Q32NZ6-1]
GeneIDi74424.
KEGGimmu:74424.
UCSCiuc009jke.2. mouse. [Q32NZ6-1]
uc009jkg.2. mouse. [Q32NZ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236495 mRNA. Translation: AAP69873.1.
AK016573 mRNA. Translation: BAB30314.1.
AY263159 mRNA. Translation: AAP78774.1.
BC046390 mRNA. Translation: AAH46390.1.
BC108382 mRNA. Translation: AAI08383.1.
CCDSiCCDS21773.1. [Q32NZ6-2]
CCDS52374.1. [Q32NZ6-1]
RefSeqiNP_001098722.1. NM_001105252.1. [Q32NZ6-1]
NP_083206.1. NM_028930.3. [Q32NZ6-2]
XP_011240225.1. XM_011241923.1. [Q32NZ6-1]
XP_011240226.1. XM_011241924.1. [Q32NZ6-1]
XP_011240227.1. XM_011241925.1. [Q32NZ6-1]
UniGeneiMm.11068.

3D structure databases

ProteinModelPortaliQ32NZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095694.

PTM databases

iPTMnetiQ32NZ6.
PhosphoSiteiQ32NZ6.

Proteomic databases

MaxQBiQ32NZ6.
PaxDbiQ32NZ6.
PRIDEiQ32NZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057320; ENSMUSP00000049784; ENSMUSG00000030650. [Q32NZ6-2]
ENSMUST00000098088; ENSMUSP00000095694; ENSMUSG00000030650. [Q32NZ6-1]
ENSMUST00000121715; ENSMUSP00000112434; ENSMUSG00000030650. [Q32NZ6-1]
ENSMUST00000121744; ENSMUSP00000114137; ENSMUSG00000030650. [Q32NZ6-1]
GeneIDi74424.
KEGGimmu:74424.
UCSCiuc009jke.2. mouse. [Q32NZ6-1]
uc009jkg.2. mouse. [Q32NZ6-2]

Organism-specific databases

CTDi79838.
MGIiMGI:1921674. Tmc5.

Phylogenomic databases

eggNOGiENOG410IH09. Eukaryota.
ENOG410XR0Y. LUCA.
GeneTreeiENSGT00760000119171.
HOGENOMiHOG000154633.
HOVERGENiHBG108587.
InParanoidiQ32NZ6.
OMAiHAYFLTI.
OrthoDBiEOG7D85XD.
PhylomeDBiQ32NZ6.
TreeFamiTF313462.

Miscellaneous databases

PROiQ32NZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ32NZ6.
CleanExiMM_TMC5.
ExpressionAtlasiQ32NZ6. baseline and differential.
GenevisibleiQ32NZ6. MM.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins."
    Keresztes G., Mutai H., Heller S.
    BMC Genomics 4:24-24(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis."
    Kurima K., Yang Y., Sorber K., Griffith A.J.
    Genomics 82:300-308(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTMC5_MOUSE
AccessioniPrimary (citable) accession number: Q32NZ6
Secondary accession number(s): Q7TN61, Q80VR0, Q9D4F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.