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Protein

Transmembrane channel-like protein 5

Gene

Tmc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 5
Gene namesi
Name:Tmc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1921674 Tmc5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 420ExtracellularSequence analysisAdd BLAST420
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 449CytoplasmicSequence analysis8
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 487ExtracellularSequence analysisAdd BLAST17
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 581CytoplasmicSequence analysisAdd BLAST73
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 616ExtracellularSequence analysisAdd BLAST14
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 660CytoplasmicSequence analysisAdd BLAST23
Transmembranei661 – 681HelicalSequence analysisAdd BLAST21
Topological domaini682 – 694ExtracellularSequence analysisAdd BLAST13
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Topological domaini716 – 749CytoplasmicSequence analysisAdd BLAST34
Transmembranei750 – 770HelicalSequence analysisAdd BLAST21
Topological domaini771 – 796ExtracellularSequence analysisAdd BLAST26
Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 861CytoplasmicSequence analysisAdd BLAST44
Transmembranei862 – 882HelicalSequence analysisAdd BLAST21
Topological domaini883 – 967ExtracellularSequence analysisAdd BLAST85

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899671 – 967Transmembrane channel-like protein 5Add BLAST967

Proteomic databases

PaxDbiQ32NZ6
PRIDEiQ32NZ6

PTM databases

iPTMnetiQ32NZ6
PhosphoSitePlusiQ32NZ6

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000030650
CleanExiMM_TMC5
ExpressionAtlasiQ32NZ6 baseline and differential
GenevisibleiQ32NZ6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095694

Structurei

3D structure databases

ProteinModelPortaliQ32NZ6
SMRiQ32NZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH09 Eukaryota
ENOG410XR0Y LUCA
GeneTreeiENSGT00760000119171
HOGENOMiHOG000154633
HOVERGENiHBG108587
InParanoidiQ32NZ6
KOiK21988
OMAiLVWIGTF
OrthoDBiEOG091G04K4
PhylomeDBiQ32NZ6
TreeFamiTF313462

Family and domain databases

InterProiView protein in InterPro
IPR012496 TMC
PfamiView protein in Pfam
PF07810 TMC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32NZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSFHQNSSY MEDADYPGYS GSRNHTHNYL ETQDYPEFPG SQNNPGFHHP
60 70 80 90 100
RSNPHSSGSR TNPDYPYFQE EPDYPGSLSN TVYQDTRSHP FSAHSRTRPD
110 120 130 140 150
YESSIEPDYN DFRSESYHAG LPMEPDYPGS QSHPGFAGVG RSSMNYTGPR
160 170 180 190 200
TNLGYLGSLE EPDYPGAQDN SYYHSGSRPH SNLPGSRRDA GYAGSRINSY
210 220 230 240 250
PDDLGEPDYP GAENQPNSPR FYGKPDYPGA EEGDGYSSSK SLAVIRRGNG
260 270 280 290 300
PFGMLGRRNE DYPEGIGMVS MEMAGDPRNG YVNPAYTRRI SPVCPDRNLL
310 320 330 340 350
LCAHDWHTSV QGQKLIASLI PMTTRDRIKT IRNQPRTMQE KRELRKIVDK
360 370 380 390 400
EKNKQSHGIL EANCCAQCLG SLSLTYRRTR NGLSELLNYI TLWQKRFKVI
410 420 430 440 450
GGKFGTSVLS YFSFLRWLLK FNIFSFVMNF SFIIIPQFTV GAKNTLQFTG
460 470 480 490 500
LEFFTGAGYF GDTVMYYGFY TNSTIRHRMG GASYNMQLAY IFTIGACLVV
510 520 530 540 550
CFFSLLFSMA KYFRNNFINP HIYSRGIAKL IFCWDFTVTH EKAVKLKQKN
560 570 580 590 600
LSTEIRENLS ELRQENYRLT FNQQLTRFSA HVAAWLVSTG VTAACCVAVY
610 620 630 640 650
YLAEYNSEFL KTHRNPGAVL LLPFVVSCIN LAVPRFYSMF RLVERYEIPR
660 670 680 690 700
QEVYVLLVRN IFLKISIVGI LCYYWLNIVA LSGEECWETL IGQDIYRLLL
710 720 730 740 750
MDFVFSLADS LLGEFLRRLI GMKFTSLSLQ EFDIARNVLE LIYAQTLTWL
760 770 780 790 800
GIFFCPLLPF IQMITLFIMF YVKNVSLMMN FQPPSKAWRA SQMITFFIFL
810 820 830 840 850
LFFPSFTGVL CTLAITIWRL KPSADCGPFR GLPSFIQSIY SWIDTLSRRP
860 870 880 890 900
GYLWVVWIYQ NLIGSVHFFF ILTLIVLIIT YLYWQITEGR KVMIRLLHEQ
910 920 930 940 950
IINEGKDKMF LIEKLTKLQD MEKRVNPSAL DLERREVEPQ IPLHLEELGA
960
APDLRLRRSA QEENPIA
Length:967
Mass (Da):111,070
Last modified:December 6, 2005 - v1
Checksum:i92B5BE50F69F3CC4
GO
Isoform 2 (identifier: Q32NZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: Missing.
     211-309: GAENQPNSPR...LLCAHDWHTS → MQSDDQVDEI...TDESCTFHET

Show »
Length:757
Mass (Da):87,667
Checksum:i320D61A71CF51DAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti527I → V in AAP69873 (PubMed:12812529).Curated1
Sequence conflicti658V → I in AAP69873 (PubMed:12812529).Curated1
Sequence conflicti658V → I in AAH46390 (PubMed:15489334).Curated1
Sequence conflicti793M → V in AAP69873 (PubMed:12812529).Curated1
Sequence conflicti926N → D in AAP69873 (PubMed:12812529).Curated1
Sequence conflicti947E → D in AAH46390 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260471 – 210Missing in isoform 2. 3 PublicationsAdd BLAST210
Alternative sequenceiVSP_026048211 – 309GAENQ…DWHTS → MQSDDQVDEIIIEVENVPSG VQNHLVSSQIALRKSSANPA FCVLSSSAADRVDCQIFNPG NDRRHNRLLRFSSLNESISQ IYHGSECLVTDESCTFHET in isoform 2. 3 PublicationsAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236495 mRNA Translation: AAP69873.1
AK016573 mRNA Translation: BAB30314.1
AY263159 mRNA Translation: AAP78774.1
BC046390 mRNA Translation: AAH46390.1
BC108382 mRNA Translation: AAI08383.1
CCDSiCCDS21773.1 [Q32NZ6-2]
CCDS52374.1 [Q32NZ6-1]
RefSeqiNP_001098722.1, NM_001105252.1 [Q32NZ6-1]
NP_083206.1, NM_028930.3 [Q32NZ6-2]
XP_011240226.1, XM_011241924.2 [Q32NZ6-1]
UniGeneiMm.11068

Genome annotation databases

EnsembliENSMUST00000057320; ENSMUSP00000049784; ENSMUSG00000030650 [Q32NZ6-2]
ENSMUST00000098088; ENSMUSP00000095694; ENSMUSG00000030650 [Q32NZ6-1]
ENSMUST00000121715; ENSMUSP00000112434; ENSMUSG00000030650 [Q32NZ6-1]
ENSMUST00000121744; ENSMUSP00000114137; ENSMUSG00000030650 [Q32NZ6-1]
GeneIDi74424
KEGGimmu:74424
UCSCiuc009jke.2 mouse [Q32NZ6-1]
uc009jkg.2 mouse [Q32NZ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMC5_MOUSE
AccessioniPrimary (citable) accession number: Q32NZ6
Secondary accession number(s): Q7TN61, Q80VR0, Q9D4F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health