Reviewed, UniProtKB/Swiss-Prot Q32NC0 (CR021_HUMAN)

Names and origin

Protein names

Recommended name:
    UPF0711 protein C18orf21
Alternative name(s):
    HBV X-transactivated gene 13 protein

Gene names

Name:	C18orf21
Synonyms:	XTP13
ORF Names:	PNAS-124, PNAS-131

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities	Belongs to the UPF0711 family.
Sequence caution	The sequence AAK07547.1 differs from that shown. Reason: Frameshift at position 216.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	UPF0711 protein C18orf21		PRO_0000279448
Amino acid modifications
	Modified residue	117	1	Phosphoserine Ref.5
	Modified residue	122	1	Phosphoserine Ref.5
	Modified residue	126	1	Phosphoserine Ref.4 Ref.8
	Modified residue	130	1	Phosphothreonine Ref.4 Ref.8
	Modified residue	139	1	Phosphothreonine Ref.8
	Modified residue	158	1	Phosphoserine Ref.6 Ref.7
	Modified residue	161	1	Phosphoserine Ref.6
Natural variations
	Natural variant	132	1	T → A: dbSNP rs2276314. Ref.3		VAR_030903
Experimental info
	Sequence conflict	212	1	S → F in AAK07541. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q32NC0-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 3BB72C83F47F14EF	FASTA	220	24,827
	10 20 30 40 50 60 MRQKHYLEAA ARGLHDSCPG QARYLLWAYT SSHDDKSTFE ETCPYCFQLL VLDNSRVRLK 70 80 90 100 110 120 PKARLTPKIQ KLLNREARNY TLSFKEAKMV KKFKDSKSVL LITCKTCNRT VKHHGKSRSF 130 140 150 160 170 180 VSTLKSNPAT PTSKLSLKTP ERRTANPNHD MSGSKGKSPA SVFRTPTSGQ SVSTCSSKNT 190 200 210 220 SKTKKHFSQL KMLLSQNESQ KIPKVDFRNF LSSLKGGLLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[2]	"Human acute promyelocytic leukemia cell line NB4's apoptosis/differentiation related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-220. Tissue: Promyelocytic leukemia.
[3]	"Screening and cloning of the target genes transactivated by hepatitis B virus X protein by microarray assay." Cheng J., Liu Y., Hong Y., Wang J.-J., Yang Q. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-220, VARIANT ALA-132.
[4]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126 AND THR-130, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-122, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158 AND SER-161, MASS SPECTROMETRY.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; THR-130 AND THR-139, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC108730 mRNA. Translation: AAI08731.1. BC119765 mRNA. Translation: AAI19766.1. BC119766 mRNA. Translation: AAI19767.1. AF277182 mRNA. Translation: AAK07541.1. Different initiation. AF277189 mRNA. Translation: AAK07547.1. Sequence problems. AY631401 mRNA. Translation: AAT51696.1.
IPI	IPI00647192.
RefSeq	NP_113634.3.
UniGene	Hs.37883
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q32NC0.
Proteomic databases
PRIDE	Q32NC0.
Genome annotation databases
Ensembl	ENST00000333234; ENSP00000329492; ENSG00000141428; Homo sapiens. [Genome view]
GeneID	83608.
KEGG	hsa:83608.
UCSC	uc002kzc.1. human.
Organism-specific databases
CTD	83608.
GeneCards	GC18P031806.
HGNC	HGNC:28802. C18orf21.
PharmGKB	PA134888949.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q32NC0.
InParanoid	Q32NC0.
OrthoDB	EOG9W3W6W.
Gene expression databases
ArrayExpress	Q32NC0.
Bgee	Q32NC0.
CleanEx	HS_C18orf21.
Genevestigator	Q32NC0.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	72563.

Entry information

Entry name

CR021_HUMAN

Accession

Primary (citable) accession number: Q32NC0
Secondary accession number(s): Q6GW03, Q9BXV6, Q9BXW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	December 6, 2005
Last modified:	December 15, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.