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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

Mitf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Gene namesi
Name:MitfImported
ORF Names:mCG_128488Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104554. Mitf.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

MaxQBiQ32MU7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035158.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044938.

Structurei

3D structure databases

SMRiQ32MU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 257BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili250 – 291Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
HOGENOMiHOG000231368.
HOVERGENiHBG006768.
KOiK09455.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR030532. MITF.
PANTHERiPTHR12565:SF258. PTHR12565:SF258. 1 hit.
PfamiView protein in Pfam
PF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32MU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEMLEYSHY QVQTHLENPT KYHIQQAQRH QVKQYLSTTL ANKHASQVLS
60 70 80 90 100
SPCPNQPGDH AMPPVPGSSA PNSPMAMLTL NSNCEKEAFY KFEEQSRAES
110 120 130 140 150
ECPGMNTHSR ASCMQMDDVI DDIISLESSY NEEILGLMDP ALQMANTLPV
160 170 180 190 200
SGNLIDLYSN QGLPPPGLTI SNSCPANLPN IKRELTACIF PTESEARALA
210 220 230 240 250
KERQKKDNHN LIERRRRFNI NDRIKELGTL IPKSNDPDMR WNKGTILKAS
260 270 280 290 300
VDYIRKLQRE QQRAKDLENR QKKLEHANRH LLLRVQELEM QARAHGLSLI
310 320 330 340 350
PSTGLCSPDL VNRIIKQEPV LENCSQELVQ HQADLTCTTT LDLTDGTITF
360 370 380 390 400
TNNLGTMPES SPAYSIPRKM GSNLEDILMD DALSPVGVTD PLLSSVSPGA
410
SKTSSRRSSM SAEETEHAC
Length:419
Mass (Da):46,769
Last modified:December 6, 2005 - v1
Checksum:i2620A6F93CDED178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108976 mRNA. Translation: AAI08977.1.
CH466523 Genomic DNA. Translation: EDK99359.1.
RefSeqiNP_032627.1. NM_008601.3.
UniGeneiMm.333284.
Mm.454504.

Genome annotation databases

GeneIDi17342.
KEGGimmu:17342.
UCSCiuc009dbd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108976 mRNA. Translation: AAI08977.1.
CH466523 Genomic DNA. Translation: EDK99359.1.
RefSeqiNP_032627.1. NM_008601.3.
UniGeneiMm.333284.
Mm.454504.

3D structure databases

SMRiQ32MU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044938.

Proteomic databases

MaxQBiQ32MU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17342.
KEGGimmu:17342.
UCSCiuc009dbd.2. mouse.

Organism-specific databases

CTDi4286.
MGIiMGI:104554. Mitf.

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
HOGENOMiHOG000231368.
HOVERGENiHBG006768.
KOiK09455.

Miscellaneous databases

ChiTaRSiMitf. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035158.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR030532. MITF.
PANTHERiPTHR12565:SF258. PTHR12565:SF258. 1 hit.
PfamiView protein in Pfam
PF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ32MU7_MOUSE
AccessioniPrimary (citable) accession number: Q32MU7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 7, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.