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Protein

Protein FAM214A

Gene

FAM214A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM214A
Gene namesi
Name:FAM214A
Synonyms:KIAA1370
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25609. FAM214A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671609.

Polymorphism and mutation databases

BioMutaiFAM214A.
DMDMi166218826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10761076Protein FAM214APRO_0000315613Add
BLAST

Proteomic databases

EPDiQ32MH5.
PaxDbiQ32MH5.
PRIDEiQ32MH5.

PTM databases

iPTMnetiQ32MH5.
PhosphoSiteiQ32MH5.

Expressioni

Gene expression databases

BgeeiQ32MH5.
CleanExiHS_KIAA1370.
ExpressionAtlasiQ32MH5. baseline and differential.
GenevisibleiQ32MH5. HS.

Organism-specific databases

HPAiHPA039369.
HPA040180.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-2866142,EBI-618309
KRT40Q6A1623EBI-2866142,EBI-10171697
MAGEA6P433603EBI-2866142,EBI-1045155
MID2Q9UJV3-23EBI-2866142,EBI-10172526
SSX2IPQ9Y2D83EBI-2866142,EBI-2212028
TRIM27P143733EBI-2866142,EBI-719493

Protein-protein interaction databases

BioGridi121108. 8 interactions.
IntActiQ32MH5. 8 interactions.
STRINGi9606.ENSP00000261844.

Structurei

3D structure databases

ProteinModelPortaliQ32MH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM214 family.Curated

Phylogenomic databases

eggNOGiKOG2306. Eukaryota.
ENOG41115V6. LUCA.
GeneTreeiENSGT00530000063568.
HOGENOMiHOG000113164.
HOVERGENiHBG108035.
InParanoidiQ32MH5.
OMAiQSCYPVT.
OrthoDBiEOG7Z3F41.
PhylomeDBiQ32MH5.
TreeFamiTF325496.

Family and domain databases

InterProiIPR025261. DUF4210.
IPR033473. FAM214/SPAC3H8.04_C.
[Graphical view]
PfamiPF13889. Chromosome_seg. 1 hit.
PF13915. DUF4210. 1 hit.
[Graphical view]
SMARTiSM01177. DUF4210. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32MH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPDRDTLDE YFEYDAEEFL VSLALLITEG RTPECSVKGR TESFHCPPAQ
60 70 80 90 100
SCYPVTTKHE CSDKLAQCRQ ARRTRSEVTL LWKNNLPIMV EMMLLPDCCY
110 120 130 140 150
SDDGPTTEGI DLNDPAIKQD ALLLERWILE PVPRQNGDRF IEEKTLLLAV
160 170 180 190 200
RSFVFFSQLS AWLSVSHGAI PRNILYRISA ADVDLQWNFS QTPIEHVFPV
210 220 230 240 250
PNVSHNVALK VSVQSLPRQS NYPVLTCSIH TNIGLYEKRI QQHKLKTHQH
260 270 280 290 300
HNPNEAEQCG TNSSQRLCSK QTWTMAPESV LHAKSGPSPE YTAAVKNIKL
310 320 330 340 350
YPGTGSKSDH GTSQANILGF SGIGDIKSQE TSVRTLKSFS MVDSSISNRQ
360 370 380 390 400
SFWQSAGETN PLIGSLIQER QEIIARIAQH LIHCDPSTSH VSGRPFNTQE
410 420 430 440 450
SSSLHSKLFR VSQENENVGK GKEAFSMTFG SPEFSSPEDT NEGKIRLKPE
460 470 480 490 500
TPRSETCISN DFYSHMPVGE TNPLIGSLLQ ERQDVIARIA QHLEHIDPTA
510 520 530 540 550
SHIPRQSFNM HDSSSVASKV FRSSYEDKNL LKKNKDESSV SISHTKCSLL
560 570 580 590 600
GDISDGKNLV PNKCFTSFKN NSKEKCSLKH QTRNQCQNNP SEIIQSTYQE
610 620 630 640 650
TQNKSSSLST SSILSQHKEN NLDLTSRFKE QEMSNGIDKQ YSNCTTIDKQ
660 670 680 690 700
ICTNKYKEKI INENYNPKFF GNLQSDDSKK NDSKIKVTVL EMSEYLNKYE
710 720 730 740 750
SMSSNKDSKR PKTCEQNTQL NSIENYLNKD NEGFKCKKSD QLKNEQDKQE
760 770 780 790 800
DPTNEKSQNY SQRRSIKDCL STCEQPKNTE VLRTTLKHSN VWRKHNFHSL
810 820 830 840 850
DGTSTRAFHP QTGLPLLSSP VPQRKTQSGC FDLDSSLLHL KSFSSRSPRP
860 870 880 890 900
CLNIEDDPDI HEKPFLSSSA PPITSLSLLG NFEESVLNYR FDPLGIVDGF
910 920 930 940 950
TAEVGASGAF CPTHLTLPVE VSFYSVSDDN APSPYMGVIT LESLGKRGYR
960 970 980 990 1000
VPPSGTIQVT LFNPNKTVVK MFVVIYDLRD MPANHQTFLR QRTFSVPVKQ
1010 1020 1030 1040 1050
EVKRSVNKEN IRHTEERLLR YLIHLRFQSS KSGKIYLHRD VRLLFSRKSM
1060 1070
EVDSGAAYEL KSYTESPTNP QFSPRC
Length:1,076
Mass (Da):121,670
Last modified:January 15, 2008 - v2
Checksum:i304B1C93DB92B18E
GO
Isoform 2 (identifier: Q32MH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     960-963: TLFN → VCVL
     964-1076: Missing.

Show »
Length:963
Mass (Da):108,211
Checksum:iB5F260D26383BDD2
GO
Isoform 3 (identifier: Q32MH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MKPDR → MVFSGNKGLHRE

Note: No experimental confirmation available.
Show »
Length:1,083
Mass (Da):122,398
Checksum:iA7519EA191A38F42
GO

Sequence cautioni

The sequence BAA91936.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92608.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG57156.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411T → I in AAI09128 (PubMed:15489334).Curated
Sequence conflicti207 – 2071V → A in BAF85606 (PubMed:14702039).Curated
Sequence conflicti610 – 6101T → A in BAF85606 (PubMed:14702039).Curated
Sequence conflicti610 – 6101T → A in BAG57301 (PubMed:14702039).Curated
Sequence conflicti610 – 6101T → A in AAI09129 (PubMed:15489334).Curated
Sequence conflicti641 – 6411Y → C in BAG57301 (PubMed:14702039).Curated
Sequence conflicti750 – 7501E → G in BAF85606 (PubMed:14702039).Curated
Sequence conflicti956 – 9561T → A in BAA91936 (PubMed:14702039).Curated
Sequence conflicti1028 – 10281Q → R in AAH83498 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351Q → R.
Corresponds to variant rs8036680 [ dbSNP | Ensembl ].
VAR_038258
Natural varianti560 – 5601V → I.4 Publications
Corresponds to variant rs12915981 [ dbSNP | Ensembl ].
VAR_038259

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 55MKPDR → MVFSGNKGLHRE in isoform 3. 1 PublicationVSP_042435
Alternative sequencei960 – 9634TLFN → VCVL in isoform 2. 2 PublicationsVSP_030580
Alternative sequencei964 – 1076113Missing in isoform 2. 2 PublicationsVSP_030581Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037791 mRNA. Translation: BAA92608.1. Different initiation.
AK001842 mRNA. Translation: BAA91936.1. Different initiation.
AK292917 mRNA. Translation: BAF85606.1.
AK293730 mRNA. Translation: BAG57156.1. Different initiation.
AK293920 mRNA. Translation: BAG57301.1.
AC009754 Genomic DNA. No translation available.
AC025917 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77460.1.
BC040548 mRNA. Translation: AAH40548.1.
BC058839 mRNA. Translation: AAH58839.1.
BC083498 mRNA. Translation: AAH83498.1.
BC109127 mRNA. Translation: AAI09128.1.
BC109128 mRNA. Translation: AAI09129.1.
CCDSiCCDS45263.1. [Q32MH5-1]
CCDS66773.1. [Q32MH5-3]
RefSeqiNP_001273424.1. NM_001286495.1. [Q32MH5-3]
NP_062546.2. NM_019600.3. [Q32MH5-1]
XP_005254604.1. XM_005254547.1. [Q32MH5-1]
XP_005254605.1. XM_005254548.1. [Q32MH5-1]
XP_011520091.1. XM_011521789.1. [Q32MH5-1]
UniGeneiHs.152385.

Genome annotation databases

EnsembliENST00000261844; ENSP00000261844; ENSG00000047346. [Q32MH5-1]
ENST00000534964; ENSP00000444447; ENSG00000047346. [Q32MH5-2]
ENST00000546305; ENSP00000443598; ENSG00000047346. [Q32MH5-3]
ENST00000619572; ENSP00000484641; ENSG00000047346. [Q32MH5-1]
GeneIDi56204.
KEGGihsa:56204.
UCSCiuc002acg.6. human. [Q32MH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037791 mRNA. Translation: BAA92608.1. Different initiation.
AK001842 mRNA. Translation: BAA91936.1. Different initiation.
AK292917 mRNA. Translation: BAF85606.1.
AK293730 mRNA. Translation: BAG57156.1. Different initiation.
AK293920 mRNA. Translation: BAG57301.1.
AC009754 Genomic DNA. No translation available.
AC025917 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77460.1.
BC040548 mRNA. Translation: AAH40548.1.
BC058839 mRNA. Translation: AAH58839.1.
BC083498 mRNA. Translation: AAH83498.1.
BC109127 mRNA. Translation: AAI09128.1.
BC109128 mRNA. Translation: AAI09129.1.
CCDSiCCDS45263.1. [Q32MH5-1]
CCDS66773.1. [Q32MH5-3]
RefSeqiNP_001273424.1. NM_001286495.1. [Q32MH5-3]
NP_062546.2. NM_019600.3. [Q32MH5-1]
XP_005254604.1. XM_005254547.1. [Q32MH5-1]
XP_005254605.1. XM_005254548.1. [Q32MH5-1]
XP_011520091.1. XM_011521789.1. [Q32MH5-1]
UniGeneiHs.152385.

3D structure databases

ProteinModelPortaliQ32MH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121108. 8 interactions.
IntActiQ32MH5. 8 interactions.
STRINGi9606.ENSP00000261844.

PTM databases

iPTMnetiQ32MH5.
PhosphoSiteiQ32MH5.

Polymorphism and mutation databases

BioMutaiFAM214A.
DMDMi166218826.

Proteomic databases

EPDiQ32MH5.
PaxDbiQ32MH5.
PRIDEiQ32MH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261844; ENSP00000261844; ENSG00000047346. [Q32MH5-1]
ENST00000534964; ENSP00000444447; ENSG00000047346. [Q32MH5-2]
ENST00000546305; ENSP00000443598; ENSG00000047346. [Q32MH5-3]
ENST00000619572; ENSP00000484641; ENSG00000047346. [Q32MH5-1]
GeneIDi56204.
KEGGihsa:56204.
UCSCiuc002acg.6. human. [Q32MH5-1]

Organism-specific databases

CTDi56204.
GeneCardsiFAM214A.
HGNCiHGNC:25609. FAM214A.
HPAiHPA039369.
HPA040180.
neXtProtiNX_Q32MH5.
PharmGKBiPA142671609.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2306. Eukaryota.
ENOG41115V6. LUCA.
GeneTreeiENSGT00530000063568.
HOGENOMiHOG000113164.
HOVERGENiHBG108035.
InParanoidiQ32MH5.
OMAiQSCYPVT.
OrthoDBiEOG7Z3F41.
PhylomeDBiQ32MH5.
TreeFamiTF325496.

Miscellaneous databases

ChiTaRSiFAM214A. human.
GenomeRNAii56204.
PROiQ32MH5.

Gene expression databases

BgeeiQ32MH5.
CleanExiHS_KIAA1370.
ExpressionAtlasiQ32MH5. baseline and differential.
GenevisibleiQ32MH5. HS.

Family and domain databases

InterProiIPR025261. DUF4210.
IPR033473. FAM214/SPAC3H8.04_C.
[Graphical view]
PfamiPF13889. Chromosome_seg. 1 hit.
PF13915. DUF4210. 1 hit.
[Graphical view]
SMARTiSM01177. DUF4210. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-560.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-1076 (ISOFORM 2), VARIANT ILE-560.
    Tissue: Cerebellum, Placenta and Trachea.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-560.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-560.
    Tissue: Hypothalamus, Skin and Testis.

Entry informationi

Entry nameiF214A_HUMAN
AccessioniPrimary (citable) accession number: Q32MH5
Secondary accession number(s): A8KA52
, B4DEP5, B4DF40, F5H8G0, Q32MH6, Q4G0R7, Q5XJ16, Q6PDA3, Q9NV24, Q9P2H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.