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Q32MD9

- CDON_MOUSE

UniProt

Q32MD9 - CDON_MOUSE

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Protein

Cell adhesion molecule-related/down-regulated by oncogenes

Gene

Cdon

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3.2 Publications

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. cell fate specification Source: MGI
  3. cerebral cortex development Source: MGI
  4. embryonic body morphogenesis Source: MGI
  5. embryonic morphogenesis Source: MGI
  6. embryonic retina morphogenesis in camera-type eye Source: MGI
  7. lens development in camera-type eye Source: MGI
  8. myoblast fusion Source: MGI
  9. positive regulation of MAPK cascade Source: MGI
  10. positive regulation of myoblast differentiation Source: UniProtKB
  11. positive regulation of neural precursor cell proliferation Source: MGI
  12. positive regulation of neuron differentiation Source: MGI
  13. positive regulation of protein phosphorylation Source: MGI
  14. positive regulation of skeletal muscle tissue development Source: MGI
  15. positive regulation of small GTPase mediated signal transduction Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. regulation of neuron differentiation Source: MGI
  18. regulation of protein heterodimerization activity Source: MGI
  19. regulation of striated muscle tissue development Source: MGI
  20. single organismal cell-cell adhesion Source: UniProtKB
  21. skeletal muscle satellite cell differentiation Source: MGI
  22. smoothened signaling pathway Source: MGI
  23. striated muscle cell differentiation Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule-related/down-regulated by oncogenes
Gene namesi
Name:Cdon
Synonyms:Cdo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1926387. Cdon.

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 12501226Cell adhesion molecule-related/down-regulated by oncogenesPRO_0000234055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 96PROSITE-ProRule annotation
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi140 ↔ 190PROSITE-ProRule annotation
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi242 ↔ 289PROSITE-ProRule annotation
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi332 ↔ 379PROSITE-ProRule annotation
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi425 ↔ 499PROSITE-ProRule annotation
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi869 – 8691N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ32MD9.

PTM databases

PhosphoSiteiQ32MD9.

Expressioni

Tissue specificityi

Highly expressed in somites and the dorsal lips of the neural tube during embryogenesis. Detected at very low levels in adult tissues.1 Publication

Inductioni

Transiently up-regulated during myoblast differentiation.1 Publication

Gene expression databases

BgeeiQ32MD9.
ExpressionAtlasiQ32MD9. baseline and differential.
GenevestigatoriQ32MD9.

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Abl1P005202EBI-7017034,EBI-914519

Protein-protein interaction databases

BioGridi208333. 3 interactions.
DIPiDIP-57227N.
IntActiQ32MD9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ32MD9.
SMRiQ32MD9. Positions 26-920.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 962938ExtracellularSequence AnalysisAdd
BLAST
Topological domaini984 – 1250267CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei963 – 98321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11386Ig-like C2-type 1Add
BLAST
Domaini119 – 20385Ig-like C2-type 2Add
BLAST
Domaini224 – 30279Ig-like C2-type 3Add
BLAST
Domaini309 – 39587Ig-like C2-type 4Add
BLAST
Domaini404 – 515112Ig-like C2-type 5Add
BLAST
Domaini572 – 673102Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini719 – 81496Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini822 – 922101Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150729.
GeneTreeiENSGT00760000118886.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiQ32MD9.
OMAiVSDTQIM.
OrthoDBiEOG7MD4PB.
TreeFamiTF332268.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32MD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHPDLGPLWT LLYVLVILCS SVSSDLAPYF ISEPLSAVQK LGRPVVLHCS
60 70 80 90 100
AKPVTARISW LHNGKRLDRN TEQIKIHRGT LTILSLNPSL SGCYQCVANN
110 120 130 140 150
SVGAVVSGPA TVSAAALGDF DSSTMHVITA EEKNTGFIGC RVPESNPKAE
160 170 180 190 200
VRYKIRGKWL KHSTGNYIIL PSGNLQVLNV SSKDKGSYKC AAYNPVTSEL
210 220 230 240 250
KVEPTGRKLL VSRPSSNGFH ILHPALSQAL AVLPHSPVTL ECVVSGVPAS
260 270 280 290 300
QVYWLKDGQD AVAGSNWRRL YSHLATASID PADSGNYSCV VGNKSGDVKH
310 320 330 340 350
VTYMVNVLEH ASISKGLHDQ KVSLGATVHF TCDVHGNPAP NRTWFHNAQP
360 370 380 390 400
IHPSSRHLTE GNVLKITRVV MEDSGLYQCV ADNGIGFMQS TGRLQIEQDS
410 420 430 440 450
GWKPVIVTAP ANIEVMDGDF VTLSCNATGV PVPVIHWYGR HGLITSHPSQ
460 470 480 490 500
VLRSKPRKSH LFRPGDLDLE PVYLIMSQAG SSSLSIQAVT LEHAGKYTCE
510 520 530 540 550
ATNKHGSTQS EAFLTVVPFE TNTKAESVTP SEASQNDERD PQDGSESSLL
560 570 580 590 600
NLFPVKVHPS GVELPAERNA SVPDAPNILS PPQTHMPDTY NLVWRAGRDG
610 620 630 640 650
GMPINAYFVK YRKLDDGSGA VGSWHTVRVP GSENELHLTE LEPSSLYEVL
660 670 680 690 700
MVARSAVGEG QPAMLTFRTS KEKMASSKNT QASFPPVGVP KRPVTAEASN
710 720 730 740 750
SNFGVVLTDS SRHSGVPEAP DRPTISMASE TSVYVTWIPR ANGGSPITAF
760 770 780 790 800
KVEYKRMRTS DWLVAAEDIP PSKLSVEVRS LEPGSIYKFR VIAINHYGES
810 820 830 840 850
FRSSASRPYQ VAGFPNRFSN RPITGPHIAY TEAVSDTQIM LKWTYVPSSN
860 870 880 890 900
NNTPIQGFYI YYRPTDSDND SDYKRDVVEG SKQWHTIGHL QPETSYDIKM
910 920 930 940 950
QCFNEGGESE FSNVMICETK VKRVPGASDY PVKELSTPPS SSGNAGNVGP
960 970 980 990 1000
ATSPARSSDM LYLIVGCVLG VMVLILMVFI ALCLWKSRQQ STIQKYDPPG
1010 1020 1030 1040 1050
YLYQGSEING QMVEYTTLSG AARINGSVHG GFLSNGCSHL HHKGPSGVNG
1060 1070 1080 1090 1100
TLSGNINGGL YSAHTNSLTR ACVEFEHPHH LVNSGGVYTA VPQMDPLECI
1110 1120 1130 1140 1150
NCRNCRNNNR CFTKTNSPLP VVPVVASYPQ GGLEMKPLNA MKVPVCPAST
1160 1170 1180 1190 1200
VPDHGQLPDD CVKDSVAPIP TQHTCCQDNI SDINSDSTED TAEFSRGDSS
1210 1220 1230 1240 1250
GHSEAEDKVF SWNPLILSPV LEDCGEKTAR SPPGPPLDGL SVVLQQAQET
Length:1,250
Mass (Da):135,422
Last modified:July 27, 2011 - v2
Checksum:i11ECD241176C2BFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti368 – 3681R → G in AAC43031. (PubMed:9786951)Curated
Sequence conflicti368 – 3681R → G in AAI09177. (PubMed:15489334)Curated
Sequence conflicti381 – 3811A → P in AAC43031. (PubMed:9786951)Curated
Sequence conflicti456 – 4561P → S in AAI09177. (PubMed:15489334)Curated
Sequence conflicti542 – 5421Q → R in AAC43031. (PubMed:9786951)Curated
Sequence conflicti542 – 5421Q → R in AAI09177. (PubMed:15489334)Curated
Sequence conflicti568 – 5681R → K in AAC43031. (PubMed:9786951)Curated
Sequence conflicti568 – 5681R → K in AAI09177. (PubMed:15489334)Curated
Sequence conflicti689 – 6891V → L in AAC43031. (PubMed:9786951)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090866 mRNA. Translation: AAC43031.1.
AC118232 Genomic DNA. No translation available.
AC159894 Genomic DNA. No translation available.
BC109176 mRNA. Translation: AAI09177.1.
CCDSiCCDS22964.1.
RefSeqiNP_067314.2. NM_021339.2.
XP_006510570.1. XM_006510507.1.
XP_006510571.1. XM_006510508.1.
XP_006510572.1. XM_006510509.1.
XP_006510573.1. XM_006510510.1.
XP_006510574.1. XM_006510511.1.
UniGeneiMm.80509.

Genome annotation databases

EnsembliENSMUST00000042842; ENSMUSP00000045547; ENSMUSG00000038119.
ENSMUST00000119129; ENSMUSP00000113977; ENSMUSG00000038119.
GeneIDi57810.
KEGGimmu:57810.
UCSCiuc009ote.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090866 mRNA. Translation: AAC43031.1 .
AC118232 Genomic DNA. No translation available.
AC159894 Genomic DNA. No translation available.
BC109176 mRNA. Translation: AAI09177.1 .
CCDSi CCDS22964.1.
RefSeqi NP_067314.2. NM_021339.2.
XP_006510570.1. XM_006510507.1.
XP_006510571.1. XM_006510508.1.
XP_006510572.1. XM_006510509.1.
XP_006510573.1. XM_006510510.1.
XP_006510574.1. XM_006510511.1.
UniGenei Mm.80509.

3D structure databases

ProteinModelPortali Q32MD9.
SMRi Q32MD9. Positions 26-920.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208333. 3 interactions.
DIPi DIP-57227N.
IntActi Q32MD9. 1 interaction.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q32MD9.

Proteomic databases

PRIDEi Q32MD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042842 ; ENSMUSP00000045547 ; ENSMUSG00000038119 .
ENSMUST00000119129 ; ENSMUSP00000113977 ; ENSMUSG00000038119 .
GeneIDi 57810.
KEGGi mmu:57810.
UCSCi uc009ote.2. mouse.

Organism-specific databases

CTDi 50937.
MGIi MGI:1926387. Cdon.

Phylogenomic databases

eggNOGi NOG150729.
GeneTreei ENSGT00760000118886.
HOGENOMi HOG000060072.
HOVERGENi HBG081073.
InParanoidi Q32MD9.
OMAi VSDTQIM.
OrthoDBi EOG7MD4PB.
TreeFami TF332268.

Miscellaneous databases

NextBioi 313990.
PROi Q32MD9.
SOURCEi Search...

Gene expression databases

Bgeei Q32MD9.
ExpressionAtlasi Q32MD9. baseline and differential.
Genevestigatori Q32MD9.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CDO, a robo-related cell surface protein that mediates myogenic differentiation."
    Kang J.-S., Mulieri P.J., Miller C., Sassoon D.A., Krauss R.S.
    J. Cell Biol. 143:403-413(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION IN A COMPLEX WITH NEO1 AND CADHERINS, FUNCTION.

Entry informationi

Entry nameiCDON_MOUSE
AccessioniPrimary (citable) accession number: Q32MD9
Secondary accession number(s): E9QKV9, O88971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3