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Q32MD9

- CDON_MOUSE

UniProt

Q32MD9 - CDON_MOUSE

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Protein
Cell adhesion molecule-related/down-regulated by oncogenes
Gene
Cdon, Cdo
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. cell fate specification Source: MGI
  3. cerebral cortex development Source: MGI
  4. embryonic body morphogenesis Source: MGI
  5. embryonic morphogenesis Source: MGI
  6. embryonic retina morphogenesis in camera-type eye Source: MGI
  7. lens development in camera-type eye Source: MGI
  8. myoblast fusion Source: MGI
  9. positive regulation of MAPK cascade Source: MGI
  10. positive regulation of myoblast differentiation Source: UniProtKB
  11. positive regulation of neural precursor cell proliferation Source: MGI
  12. positive regulation of neuron differentiation Source: MGI
  13. positive regulation of protein phosphorylation Source: MGI
  14. positive regulation of skeletal muscle tissue development Source: MGI
  15. positive regulation of small GTPase mediated signal transduction Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. regulation of neuron differentiation Source: MGI
  18. regulation of protein heterodimerization activity Source: MGI
  19. regulation of striated muscle tissue development Source: MGI
  20. satellite cell differentiation Source: MGI
  21. single organismal cell-cell adhesion Source: UniProtKB
  22. smoothened signaling pathway Source: MGI
  23. striated muscle cell differentiation Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule-related/down-regulated by oncogenes
Gene namesi
Name:Cdon
Synonyms:Cdo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1926387. Cdon.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 962938Extracellular Reviewed prediction
Add
BLAST
Transmembranei963 – 98321Helical; Reviewed prediction
Add
BLAST
Topological domaini984 – 1250267Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 12501226Cell adhesion molecule-related/down-regulated by oncogenes
PRO_0000234055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 96 By similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 190 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi242 ↔ 289 By similarity
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi332 ↔ 379 By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi425 ↔ 499 By similarity
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi869 – 8691N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ32MD9.

PTM databases

PhosphoSiteiQ32MD9.

Expressioni

Tissue specificityi

Highly expressed in somites and the dorsal lips of the neural tube during embryogenesis. Detected at very low levels in adult tissues.1 Publication

Inductioni

Transiently up-regulated during myoblast differentiation.1 Publication

Gene expression databases

ArrayExpressiQ32MD9.
BgeeiQ32MD9.
GenevestigatoriQ32MD9.

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Abl1P005202EBI-7017034,EBI-914519

Protein-protein interaction databases

BioGridi208333. 3 interactions.
DIPiDIP-57227N.
IntActiQ32MD9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ32MD9.
SMRiQ32MD9. Positions 26-920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11386Ig-like C2-type 1
Add
BLAST
Domaini119 – 20385Ig-like C2-type 2
Add
BLAST
Domaini224 – 30279Ig-like C2-type 3
Add
BLAST
Domaini309 – 39587Ig-like C2-type 4
Add
BLAST
Domaini404 – 515112Ig-like C2-type 5
Add
BLAST
Domaini572 – 673102Fibronectin type-III 1
Add
BLAST
Domaini719 – 81496Fibronectin type-III 2
Add
BLAST
Domaini822 – 922101Fibronectin type-III 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150729.
GeneTreeiENSGT00750000117685.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiQ32MD9.
OMAiVSDTQIM.
OrthoDBiEOG7MD4PB.
TreeFamiTF332268.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32MD9-1 [UniParc]FASTAAdd to Basket

« Hide

MHPDLGPLWT LLYVLVILCS SVSSDLAPYF ISEPLSAVQK LGRPVVLHCS     50
AKPVTARISW LHNGKRLDRN TEQIKIHRGT LTILSLNPSL SGCYQCVANN 100
SVGAVVSGPA TVSAAALGDF DSSTMHVITA EEKNTGFIGC RVPESNPKAE 150
VRYKIRGKWL KHSTGNYIIL PSGNLQVLNV SSKDKGSYKC AAYNPVTSEL 200
KVEPTGRKLL VSRPSSNGFH ILHPALSQAL AVLPHSPVTL ECVVSGVPAS 250
QVYWLKDGQD AVAGSNWRRL YSHLATASID PADSGNYSCV VGNKSGDVKH 300
VTYMVNVLEH ASISKGLHDQ KVSLGATVHF TCDVHGNPAP NRTWFHNAQP 350
IHPSSRHLTE GNVLKITRVV MEDSGLYQCV ADNGIGFMQS TGRLQIEQDS 400
GWKPVIVTAP ANIEVMDGDF VTLSCNATGV PVPVIHWYGR HGLITSHPSQ 450
VLRSKPRKSH LFRPGDLDLE PVYLIMSQAG SSSLSIQAVT LEHAGKYTCE 500
ATNKHGSTQS EAFLTVVPFE TNTKAESVTP SEASQNDERD PQDGSESSLL 550
NLFPVKVHPS GVELPAERNA SVPDAPNILS PPQTHMPDTY NLVWRAGRDG 600
GMPINAYFVK YRKLDDGSGA VGSWHTVRVP GSENELHLTE LEPSSLYEVL 650
MVARSAVGEG QPAMLTFRTS KEKMASSKNT QASFPPVGVP KRPVTAEASN 700
SNFGVVLTDS SRHSGVPEAP DRPTISMASE TSVYVTWIPR ANGGSPITAF 750
KVEYKRMRTS DWLVAAEDIP PSKLSVEVRS LEPGSIYKFR VIAINHYGES 800
FRSSASRPYQ VAGFPNRFSN RPITGPHIAY TEAVSDTQIM LKWTYVPSSN 850
NNTPIQGFYI YYRPTDSDND SDYKRDVVEG SKQWHTIGHL QPETSYDIKM 900
QCFNEGGESE FSNVMICETK VKRVPGASDY PVKELSTPPS SSGNAGNVGP 950
ATSPARSSDM LYLIVGCVLG VMVLILMVFI ALCLWKSRQQ STIQKYDPPG 1000
YLYQGSEING QMVEYTTLSG AARINGSVHG GFLSNGCSHL HHKGPSGVNG 1050
TLSGNINGGL YSAHTNSLTR ACVEFEHPHH LVNSGGVYTA VPQMDPLECI 1100
NCRNCRNNNR CFTKTNSPLP VVPVVASYPQ GGLEMKPLNA MKVPVCPAST 1150
VPDHGQLPDD CVKDSVAPIP TQHTCCQDNI SDINSDSTED TAEFSRGDSS 1200
GHSEAEDKVF SWNPLILSPV LEDCGEKTAR SPPGPPLDGL SVVLQQAQET 1250
Length:1,250
Mass (Da):135,422
Last modified:July 27, 2011 - v2
Checksum:i11ECD241176C2BFC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti368 – 3681R → G in AAC43031. 1 Publication
Sequence conflicti368 – 3681R → G in AAI09177. 1 Publication
Sequence conflicti381 – 3811A → P in AAC43031. 1 Publication
Sequence conflicti456 – 4561P → S in AAI09177. 1 Publication
Sequence conflicti542 – 5421Q → R in AAC43031. 1 Publication
Sequence conflicti542 – 5421Q → R in AAI09177. 1 Publication
Sequence conflicti568 – 5681R → K in AAC43031. 1 Publication
Sequence conflicti568 – 5681R → K in AAI09177. 1 Publication
Sequence conflicti689 – 6891V → L in AAC43031. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090866 mRNA. Translation: AAC43031.1.
AC118232 Genomic DNA. No translation available.
AC159894 Genomic DNA. No translation available.
BC109176 mRNA. Translation: AAI09177.1.
CCDSiCCDS22964.1.
RefSeqiNP_067314.2. NM_021339.2.
XP_006510570.1. XM_006510507.1.
XP_006510571.1. XM_006510508.1.
XP_006510572.1. XM_006510509.1.
XP_006510573.1. XM_006510510.1.
XP_006510574.1. XM_006510511.1.
UniGeneiMm.80509.

Genome annotation databases

EnsembliENSMUST00000042842; ENSMUSP00000045547; ENSMUSG00000038119.
ENSMUST00000119129; ENSMUSP00000113977; ENSMUSG00000038119.
GeneIDi57810.
KEGGimmu:57810.
UCSCiuc009ote.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090866 mRNA. Translation: AAC43031.1 .
AC118232 Genomic DNA. No translation available.
AC159894 Genomic DNA. No translation available.
BC109176 mRNA. Translation: AAI09177.1 .
CCDSi CCDS22964.1.
RefSeqi NP_067314.2. NM_021339.2.
XP_006510570.1. XM_006510507.1.
XP_006510571.1. XM_006510508.1.
XP_006510572.1. XM_006510509.1.
XP_006510573.1. XM_006510510.1.
XP_006510574.1. XM_006510511.1.
UniGenei Mm.80509.

3D structure databases

ProteinModelPortali Q32MD9.
SMRi Q32MD9. Positions 26-920.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208333. 3 interactions.
DIPi DIP-57227N.
IntActi Q32MD9. 1 interaction.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q32MD9.

Proteomic databases

PRIDEi Q32MD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042842 ; ENSMUSP00000045547 ; ENSMUSG00000038119 .
ENSMUST00000119129 ; ENSMUSP00000113977 ; ENSMUSG00000038119 .
GeneIDi 57810.
KEGGi mmu:57810.
UCSCi uc009ote.2. mouse.

Organism-specific databases

CTDi 50937.
MGIi MGI:1926387. Cdon.

Phylogenomic databases

eggNOGi NOG150729.
GeneTreei ENSGT00750000117685.
HOGENOMi HOG000060072.
HOVERGENi HBG081073.
InParanoidi Q32MD9.
OMAi VSDTQIM.
OrthoDBi EOG7MD4PB.
TreeFami TF332268.

Miscellaneous databases

NextBioi 313990.
PROi Q32MD9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q32MD9.
Bgeei Q32MD9.
Genevestigatori Q32MD9.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CDO, a robo-related cell surface protein that mediates myogenic differentiation."
    Kang J.-S., Mulieri P.J., Miller C., Sassoon D.A., Krauss R.S.
    J. Cell Biol. 143:403-413(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION IN A COMPLEX WITH NEO1 AND CADHERINS, FUNCTION.

Entry informationi

Entry nameiCDON_MOUSE
AccessioniPrimary (citable) accession number: Q32MD9
Secondary accession number(s): E9QKV9, O88971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi