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Q32MD9

- CDON_MOUSE

UniProt

Q32MD9 - CDON_MOUSE

Protein

Cell adhesion molecule-related/down-regulated by oncogenes

Gene

Cdon

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. cell fate specification Source: MGI
    3. cerebral cortex development Source: MGI
    4. embryonic body morphogenesis Source: MGI
    5. embryonic morphogenesis Source: MGI
    6. embryonic retina morphogenesis in camera-type eye Source: MGI
    7. lens development in camera-type eye Source: MGI
    8. myoblast fusion Source: MGI
    9. positive regulation of MAPK cascade Source: MGI
    10. positive regulation of myoblast differentiation Source: UniProtKB
    11. positive regulation of neural precursor cell proliferation Source: MGI
    12. positive regulation of neuron differentiation Source: MGI
    13. positive regulation of protein phosphorylation Source: MGI
    14. positive regulation of skeletal muscle tissue development Source: MGI
    15. positive regulation of small GTPase mediated signal transduction Source: MGI
    16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    17. regulation of neuron differentiation Source: MGI
    18. regulation of protein heterodimerization activity Source: MGI
    19. regulation of striated muscle tissue development Source: MGI
    20. single organismal cell-cell adhesion Source: UniProtKB
    21. skeletal muscle satellite cell differentiation Source: MGI
    22. smoothened signaling pathway Source: MGI
    23. striated muscle cell differentiation Source: MGI

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Gene namesi
    Name:Cdon
    Synonyms:Cdo
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1926387. Cdon.

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 12501226Cell adhesion molecule-related/down-regulated by oncogenesPRO_0000234055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 96PROSITE-ProRule annotation
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi140 ↔ 190PROSITE-ProRule annotation
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi242 ↔ 289PROSITE-ProRule annotation
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi332 ↔ 379PROSITE-ProRule annotation
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi425 ↔ 499PROSITE-ProRule annotation
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi869 – 8691N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ32MD9.

    PTM databases

    PhosphoSiteiQ32MD9.

    Expressioni

    Tissue specificityi

    Highly expressed in somites and the dorsal lips of the neural tube during embryogenesis. Detected at very low levels in adult tissues.1 Publication

    Inductioni

    Transiently up-regulated during myoblast differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ32MD9.
    BgeeiQ32MD9.
    GenevestigatoriQ32MD9.

    Interactioni

    Subunit structurei

    Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Abl1P005202EBI-7017034,EBI-914519

    Protein-protein interaction databases

    BioGridi208333. 3 interactions.
    DIPiDIP-57227N.
    IntActiQ32MD9. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32MD9.
    SMRiQ32MD9. Positions 26-920.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 962938ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini984 – 1250267CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei963 – 98321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 11386Ig-like C2-type 1Add
    BLAST
    Domaini119 – 20385Ig-like C2-type 2Add
    BLAST
    Domaini224 – 30279Ig-like C2-type 3Add
    BLAST
    Domaini309 – 39587Ig-like C2-type 4Add
    BLAST
    Domaini404 – 515112Ig-like C2-type 5Add
    BLAST
    Domaini572 – 673102Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini719 – 81496Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini822 – 922101Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150729.
    GeneTreeiENSGT00750000117685.
    HOGENOMiHOG000060072.
    HOVERGENiHBG081073.
    InParanoidiQ32MD9.
    OMAiVSDTQIM.
    OrthoDBiEOG7MD4PB.
    TreeFamiTF332268.

    Family and domain databases

    Gene3Di2.60.40.10. 9 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF07679. I-set. 3 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q32MD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPDLGPLWT LLYVLVILCS SVSSDLAPYF ISEPLSAVQK LGRPVVLHCS     50
    AKPVTARISW LHNGKRLDRN TEQIKIHRGT LTILSLNPSL SGCYQCVANN 100
    SVGAVVSGPA TVSAAALGDF DSSTMHVITA EEKNTGFIGC RVPESNPKAE 150
    VRYKIRGKWL KHSTGNYIIL PSGNLQVLNV SSKDKGSYKC AAYNPVTSEL 200
    KVEPTGRKLL VSRPSSNGFH ILHPALSQAL AVLPHSPVTL ECVVSGVPAS 250
    QVYWLKDGQD AVAGSNWRRL YSHLATASID PADSGNYSCV VGNKSGDVKH 300
    VTYMVNVLEH ASISKGLHDQ KVSLGATVHF TCDVHGNPAP NRTWFHNAQP 350
    IHPSSRHLTE GNVLKITRVV MEDSGLYQCV ADNGIGFMQS TGRLQIEQDS 400
    GWKPVIVTAP ANIEVMDGDF VTLSCNATGV PVPVIHWYGR HGLITSHPSQ 450
    VLRSKPRKSH LFRPGDLDLE PVYLIMSQAG SSSLSIQAVT LEHAGKYTCE 500
    ATNKHGSTQS EAFLTVVPFE TNTKAESVTP SEASQNDERD PQDGSESSLL 550
    NLFPVKVHPS GVELPAERNA SVPDAPNILS PPQTHMPDTY NLVWRAGRDG 600
    GMPINAYFVK YRKLDDGSGA VGSWHTVRVP GSENELHLTE LEPSSLYEVL 650
    MVARSAVGEG QPAMLTFRTS KEKMASSKNT QASFPPVGVP KRPVTAEASN 700
    SNFGVVLTDS SRHSGVPEAP DRPTISMASE TSVYVTWIPR ANGGSPITAF 750
    KVEYKRMRTS DWLVAAEDIP PSKLSVEVRS LEPGSIYKFR VIAINHYGES 800
    FRSSASRPYQ VAGFPNRFSN RPITGPHIAY TEAVSDTQIM LKWTYVPSSN 850
    NNTPIQGFYI YYRPTDSDND SDYKRDVVEG SKQWHTIGHL QPETSYDIKM 900
    QCFNEGGESE FSNVMICETK VKRVPGASDY PVKELSTPPS SSGNAGNVGP 950
    ATSPARSSDM LYLIVGCVLG VMVLILMVFI ALCLWKSRQQ STIQKYDPPG 1000
    YLYQGSEING QMVEYTTLSG AARINGSVHG GFLSNGCSHL HHKGPSGVNG 1050
    TLSGNINGGL YSAHTNSLTR ACVEFEHPHH LVNSGGVYTA VPQMDPLECI 1100
    NCRNCRNNNR CFTKTNSPLP VVPVVASYPQ GGLEMKPLNA MKVPVCPAST 1150
    VPDHGQLPDD CVKDSVAPIP TQHTCCQDNI SDINSDSTED TAEFSRGDSS 1200
    GHSEAEDKVF SWNPLILSPV LEDCGEKTAR SPPGPPLDGL SVVLQQAQET 1250
    Length:1,250
    Mass (Da):135,422
    Last modified:July 27, 2011 - v2
    Checksum:i11ECD241176C2BFC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti368 – 3681R → G in AAC43031. (PubMed:9786951)Curated
    Sequence conflicti368 – 3681R → G in AAI09177. (PubMed:15489334)Curated
    Sequence conflicti381 – 3811A → P in AAC43031. (PubMed:9786951)Curated
    Sequence conflicti456 – 4561P → S in AAI09177. (PubMed:15489334)Curated
    Sequence conflicti542 – 5421Q → R in AAC43031. (PubMed:9786951)Curated
    Sequence conflicti542 – 5421Q → R in AAI09177. (PubMed:15489334)Curated
    Sequence conflicti568 – 5681R → K in AAC43031. (PubMed:9786951)Curated
    Sequence conflicti568 – 5681R → K in AAI09177. (PubMed:15489334)Curated
    Sequence conflicti689 – 6891V → L in AAC43031. (PubMed:9786951)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090866 mRNA. Translation: AAC43031.1.
    AC118232 Genomic DNA. No translation available.
    AC159894 Genomic DNA. No translation available.
    BC109176 mRNA. Translation: AAI09177.1.
    CCDSiCCDS22964.1.
    RefSeqiNP_067314.2. NM_021339.2.
    XP_006510570.1. XM_006510507.1.
    XP_006510571.1. XM_006510508.1.
    XP_006510572.1. XM_006510509.1.
    XP_006510573.1. XM_006510510.1.
    XP_006510574.1. XM_006510511.1.
    UniGeneiMm.80509.

    Genome annotation databases

    EnsembliENSMUST00000042842; ENSMUSP00000045547; ENSMUSG00000038119.
    ENSMUST00000119129; ENSMUSP00000113977; ENSMUSG00000038119.
    GeneIDi57810.
    KEGGimmu:57810.
    UCSCiuc009ote.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF090866 mRNA. Translation: AAC43031.1 .
    AC118232 Genomic DNA. No translation available.
    AC159894 Genomic DNA. No translation available.
    BC109176 mRNA. Translation: AAI09177.1 .
    CCDSi CCDS22964.1.
    RefSeqi NP_067314.2. NM_021339.2.
    XP_006510570.1. XM_006510507.1.
    XP_006510571.1. XM_006510508.1.
    XP_006510572.1. XM_006510509.1.
    XP_006510573.1. XM_006510510.1.
    XP_006510574.1. XM_006510511.1.
    UniGenei Mm.80509.

    3D structure databases

    ProteinModelPortali Q32MD9.
    SMRi Q32MD9. Positions 26-920.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208333. 3 interactions.
    DIPi DIP-57227N.
    IntActi Q32MD9. 1 interaction.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q32MD9.

    Proteomic databases

    PRIDEi Q32MD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042842 ; ENSMUSP00000045547 ; ENSMUSG00000038119 .
    ENSMUST00000119129 ; ENSMUSP00000113977 ; ENSMUSG00000038119 .
    GeneIDi 57810.
    KEGGi mmu:57810.
    UCSCi uc009ote.2. mouse.

    Organism-specific databases

    CTDi 50937.
    MGIi MGI:1926387. Cdon.

    Phylogenomic databases

    eggNOGi NOG150729.
    GeneTreei ENSGT00750000117685.
    HOGENOMi HOG000060072.
    HOVERGENi HBG081073.
    InParanoidi Q32MD9.
    OMAi VSDTQIM.
    OrthoDBi EOG7MD4PB.
    TreeFami TF332268.

    Miscellaneous databases

    NextBioi 313990.
    PROi Q32MD9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q32MD9.
    Bgeei Q32MD9.
    Genevestigatori Q32MD9.

    Family and domain databases

    Gene3Di 2.60.40.10. 9 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF07679. I-set. 3 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CDO, a robo-related cell surface protein that mediates myogenic differentiation."
      Kang J.-S., Mulieri P.J., Miller C., Sassoon D.A., Krauss R.S.
      J. Cell Biol. 143:403-413(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION IN A COMPLEX WITH NEO1 AND CADHERINS, FUNCTION.

    Entry informationi

    Entry nameiCDON_MOUSE
    AccessioniPrimary (citable) accession number: Q32MD9
    Secondary accession number(s): E9QKV9, O88971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3