Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acid trehalase-like protein 1

Gene

ATHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH65. Glycoside Hydrolase Family 65.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid trehalase-like protein 1 (EC:3.2.1.-)
Gene namesi
Name:ATHL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26210. ATHL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672576.

Polymorphism and mutation databases

BioMutaiATHL1.
DMDMi182627595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Acid trehalase-like protein 1PRO_0000329004Add
BLAST

Proteomic databases

EPDiQ32M88.
MaxQBiQ32M88.
PaxDbiQ32M88.
PRIDEiQ32M88.

Expressioni

Gene expression databases

BgeeiQ32M88.
CleanExiHS_ATHL1.
ExpressionAtlasiQ32M88. baseline and differential.
GenevisibleiQ32M88. HS.

Organism-specific databases

HPAiHPA039383.

Interactioni

Protein-protein interaction databases

BioGridi123150. 1 interaction.
STRINGi9606.ENSP00000387185.

Structurei

3D structure databases

ProteinModelPortaliQ32M88.
SMRiQ32M88. Positions 204-652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi696 – 6994Poly-Ser

Sequence similaritiesi

Belongs to the glycosyl hydrolase 65 family.Curated

Phylogenomic databases

eggNOGiKOG4125. Eukaryota.
COG1554. LUCA.
GeneTreeiENSGT00390000006297.
HOGENOMiHOG000007761.
HOVERGENiHBG057497.
InParanoidiQ32M88.
PhylomeDBiQ32M88.
TreeFamiTF300109.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR005195. Glyco_hydro_65_M.
[Graphical view]
PfamiPF03632. Glyco_hydro_65m. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32M88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDAGEDPTT FAAHSLPSDP RLLATVTNAY LGTRVFHDTL HVSGVYNGAG
60 70 80 90 100
GDTHRAMLPS PLNVRLEAPA GMGEQLTETF ALDTNTGSFL HTLEGPRFRA
110 120 130 140 150
SQCIYAHRTL PHVLAFRVSI ARLAPGSGPI TLLLRSAFSP ESPDLDLHQG
160 170 180 190 200
PDFQGARYLY GHTLTPEQPG GPQQEVHMLW TPAPPDLTLG EGEEARTWDF
210 220 230 240 250
LTAVGGSQAE AQACLTEALQ LQARGALYTA HAQAWAQLWV ECGLDVVGPL
260 270 280 290 300
QLRQALRGSL YYLLSALPQP KAPGYICHGL SPGGLSNGSR EECYWGHVFW
310 320 330 340 350
DQDLWMFPSI LMFHPEAARA ILEYRIRTLD GALENAQNLG YQGAKFAWES
360 370 380 390 400
ADSGLEVCPE DIYGVQEVHV NGAVVLAFEL YYHTTQDLQL FREAGGWDVV
410 420 430 440 450
RAVAEFWCSR VEWSPREEKY HLRGVMSPDE YHSGVNNSVY TNVLVQNSLR
460 470 480 490 500
FAAALAQDLG LPIPSQWLAV ADKIKVPFDV EQNFHPEFDG YEPGEVVKQA
510 520 530 540 550
DVVLLGYPVP FSLSPDVRRK NLEIYEAVTS PQGPAMTWSM FAVGWMELKD
560 570 580 590 600
AVRARGLLDR SFANMAEPFK VWTENADGSG AVNFLTGMGG FLQAVVFGCT
610 620 630 640 650
GFRVTRAGVT FDPVCLSGIS RVSVSGIFYQ GNKLNFSFSE DSVTVEVTAR
660 670 680 690 700
AGPWAPHLEA ELWPSQSRLS LLPGHKVSFP RSAGRIQMSP PKLPGSSSSE
710 720 730
FPGRTFSDVR DPLQSPLWVT LGSSSPTESL TVDPASE
Note: No experimental confirmation available.
Length:737
Mass (Da):80,655
Last modified:April 8, 2008 - v2
Checksum:i6EAEEE2FF90F3CD2
GO
Isoform 2 (identifier: Q32M88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-354: DLWMFPSILM...KFAWESADSG → VSTVHPAPAT...WKVCRSLVEE
     355-737: Missing.

Show »
Length:354
Mass (Da):38,273
Checksum:iD621DE13DCBADD55
GO

Sequence cautioni

The sequence AAI09258.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI09259.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15431.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB84981.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 50014EFDGY…VVKQA → KFQLRVPWEDFFRC in BAB15431 (PubMed:14702039).CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei303 – 35452DLWMF…SADSG → VSTVHPAPATQQATHGGPRS LPSLGPGLWLGKHRDCGKRE EAWKVCRSLVEE in isoform 2. 1 PublicationVSP_032895Add
BLAST
Alternative sequencei355 – 737383Missing in isoform 2. 1 PublicationVSP_032896Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136475 Genomic DNA. No translation available.
AK074155 mRNA. Translation: BAB84981.1. Different initiation.
AK026288 mRNA. Translation: BAB15431.1. Different initiation.
BC109257 mRNA. Translation: AAI09258.1. Different initiation.
BC109258 mRNA. Translation: AAI09259.1. Different initiation.
AL832932 mRNA. Translation: CAH56316.1.
CCDSiCCDS31322.2. [Q32M88-1]
RefSeqiNP_079368.3. NM_025092.4. [Q32M88-1]
XP_011518685.1. XM_011520383.1. [Q32M88-1]
UniGeneiHs.353181.

Genome annotation databases

EnsembliENST00000409548; ENSP00000387185; ENSG00000142102. [Q32M88-1]
GeneIDi80162.
KEGGihsa:80162.
UCSCiuc010qvu.3. human. [Q32M88-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136475 Genomic DNA. No translation available.
AK074155 mRNA. Translation: BAB84981.1. Different initiation.
AK026288 mRNA. Translation: BAB15431.1. Different initiation.
BC109257 mRNA. Translation: AAI09258.1. Different initiation.
BC109258 mRNA. Translation: AAI09259.1. Different initiation.
AL832932 mRNA. Translation: CAH56316.1.
CCDSiCCDS31322.2. [Q32M88-1]
RefSeqiNP_079368.3. NM_025092.4. [Q32M88-1]
XP_011518685.1. XM_011520383.1. [Q32M88-1]
UniGeneiHs.353181.

3D structure databases

ProteinModelPortaliQ32M88.
SMRiQ32M88. Positions 204-652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123150. 1 interaction.
STRINGi9606.ENSP00000387185.

Protein family/group databases

CAZyiGH65. Glycoside Hydrolase Family 65.

Polymorphism and mutation databases

BioMutaiATHL1.
DMDMi182627595.

Proteomic databases

EPDiQ32M88.
MaxQBiQ32M88.
PaxDbiQ32M88.
PRIDEiQ32M88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409548; ENSP00000387185; ENSG00000142102. [Q32M88-1]
GeneIDi80162.
KEGGihsa:80162.
UCSCiuc010qvu.3. human. [Q32M88-1]

Organism-specific databases

CTDi80162.
GeneCardsiATHL1.
H-InvDBHIX0009341.
HGNCiHGNC:26210. ATHL1.
HPAiHPA039383.
neXtProtiNX_Q32M88.
PharmGKBiPA142672576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4125. Eukaryota.
COG1554. LUCA.
GeneTreeiENSGT00390000006297.
HOGENOMiHOG000007761.
HOVERGENiHBG057497.
InParanoidiQ32M88.
PhylomeDBiQ32M88.
TreeFamiTF300109.

Miscellaneous databases

ChiTaRSiATHL1. human.
GenomeRNAii80162.
NextBioi70465.
PROiQ32M88.

Gene expression databases

BgeeiQ32M88.
CleanExiHS_ATHL1.
ExpressionAtlasiQ32M88. baseline and differential.
GenevisibleiQ32M88. HS.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR005195. Glyco_hydro_65_M.
[Graphical view]
PfamiPF03632. Glyco_hydro_65m. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-500.
    Tissue: Small intestine.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-737.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 424-737 (ISOFORM 1).
    Tissue: Stomach.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiATHL1_HUMAN
AccessioniPrimary (citable) accession number: Q32M88
Secondary accession number(s): Q658X8, Q8TEG9, Q9H635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 16, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.