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Protein

BTB/POZ domain-containing protein 16

Gene

BTBD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 16
Gene namesi
Name:BTBD16
Synonyms:C10orf87
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26340. BTBD16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134900594.

Polymorphism and mutation databases

BioMutaiBTBD16.
DMDMi110832778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506BTB/POZ domain-containing protein 16PRO_0000247121Add
BLAST

Proteomic databases

PaxDbiQ32M84.
PeptideAtlasiQ32M84.
PRIDEiQ32M84.

PTM databases

iPTMnetiQ32M84.
PhosphoSiteiQ32M84.

Expressioni

Gene expression databases

BgeeiQ32M84.
CleanExiHS_BTBD16.
GenevisibleiQ32M84. HS.

Organism-specific databases

HPAiHPA040529.

Interactioni

Protein-protein interaction databases

BioGridi125616. 1 interaction.
STRINGi9606.ENSP00000260723.

Structurei

3D structure databases

ProteinModelPortaliQ32M84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 20657BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiENOG410INKX. Eukaryota.
ENOG410XQHV. LUCA.
GeneTreeiENSGT00390000003212.
HOGENOMiHOG000095274.
HOVERGENiHBG080936.
InParanoidiQ32M84.
KOiK10487.
OMAiKWQEFRT.
OrthoDBiEOG7DC242.
PhylomeDBiQ32M84.
TreeFamiTF316048.

Family and domain databases

InterProiIPR011333. SKP1/BTB/POZ.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32M84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIMSNTHKAR LERRVTGSTN RWRLPKQPFS GDLLSLSQMC KALSIDFEEA
60 70 80 90 100
LRNPDRLCIS QIQKFFFENF KNKDIQSGEA DVILECLGFK WELHQPQLFQ
110 120 130 140 150
SETLAKLYLK ALAQGTTHPL RELEELLRAQ SPKKTKEKSP AKRIIISLKI
160 170 180 190 200
NDPLVTKVAF ATALKNLYMS EVEINLEDLL GVLASAHILQ FSGLFQRCVD
210 220 230 240 250
VMIARLKPST IKKFYEAGCK YKEEQLTTGC EKWLEMNLVP LGGTQIHLHK
260 270 280 290 300
IPQDLLHKVL KSPRLFTFSE FHLLKTMLLW VFLQLNYKIQ AIPTYETVMT
310 320 330 340 350
FFKSFPENCC FLDRDIGRSL RPLFLCLRLH GITKGKDLEV LRHLNFFPES
360 370 380 390 400
WLDQVTVNHY HALENGGDMV HLKDLNTQAV RFGLLFNQEN TTYSKTIALY
410 420 430 440 450
GFFFKIKGLK HDTTSYSFYM QRIKHTDLES PSAVYEHNHV SLRAARLVKY
460 470 480 490 500
EIRAEALVDG KWQEFRTNQI KQKFGLTTSS CKSHTLKIQT VGIPIYVSFA

FIFPAS
Length:506
Mass (Da):58,481
Last modified:July 25, 2006 - v2
Checksum:iA5E006B7F7014AD4
GO
Isoform 2 (identifier: Q32M84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: T → TQ

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):58,609
Checksum:iDF5273A65B3A7E79
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971Q → R in BAB71658 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti318 – 3181R → Q.
Corresponds to variant rs2421013 [ dbSNP | Ensembl ].
VAR_027070
Natural varianti331 – 3311G → D.
Corresponds to variant rs986178 [ dbSNP | Ensembl ].
VAR_027071
Natural varianti439 – 4391H → P.
Corresponds to variant rs1048347 [ dbSNP | Ensembl ].
VAR_027072
Natural varianti472 – 4721Q → R.
Corresponds to variant rs10510108 [ dbSNP | Ensembl ].
VAR_027073

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei6 – 61T → TQ in isoform 2. 1 PublicationVSP_019929

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058088 mRNA. Translation: BAB71658.1.
AL135793, BX842243 Genomic DNA. Translation: CAI95133.1.
BC109262 mRNA. Translation: AAI09263.1.
BC109261 mRNA. Translation: AAI09262.1.
CCDSiCCDS31301.1. [Q32M84-1]
RefSeqiNP_001305118.1. NM_001318189.1. [Q32M84-2]
NP_653188.2. NM_144587.3. [Q32M84-1]
UniGeneiHs.422466.

Genome annotation databases

EnsembliENST00000260723; ENSP00000260723; ENSG00000138152. [Q32M84-1]
GeneIDi118663.
KEGGihsa:118663.
UCSCiuc001lgc.2. human. [Q32M84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058088 mRNA. Translation: BAB71658.1.
AL135793, BX842243 Genomic DNA. Translation: CAI95133.1.
BC109262 mRNA. Translation: AAI09263.1.
BC109261 mRNA. Translation: AAI09262.1.
CCDSiCCDS31301.1. [Q32M84-1]
RefSeqiNP_001305118.1. NM_001318189.1. [Q32M84-2]
NP_653188.2. NM_144587.3. [Q32M84-1]
UniGeneiHs.422466.

3D structure databases

ProteinModelPortaliQ32M84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125616. 1 interaction.
STRINGi9606.ENSP00000260723.

PTM databases

iPTMnetiQ32M84.
PhosphoSiteiQ32M84.

Polymorphism and mutation databases

BioMutaiBTBD16.
DMDMi110832778.

Proteomic databases

PaxDbiQ32M84.
PeptideAtlasiQ32M84.
PRIDEiQ32M84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260723; ENSP00000260723; ENSG00000138152. [Q32M84-1]
GeneIDi118663.
KEGGihsa:118663.
UCSCiuc001lgc.2. human. [Q32M84-1]

Organism-specific databases

CTDi118663.
GeneCardsiBTBD16.
HGNCiHGNC:26340. BTBD16.
HPAiHPA040529.
neXtProtiNX_Q32M84.
PharmGKBiPA134900594.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INKX. Eukaryota.
ENOG410XQHV. LUCA.
GeneTreeiENSGT00390000003212.
HOGENOMiHOG000095274.
HOVERGENiHBG080936.
InParanoidiQ32M84.
KOiK10487.
OMAiKWQEFRT.
OrthoDBiEOG7DC242.
PhylomeDBiQ32M84.
TreeFamiTF316048.

Miscellaneous databases

GenomeRNAii118663.
PROiQ32M84.

Gene expression databases

BgeeiQ32M84.
CleanExiHS_BTBD16.
GenevisibleiQ32M84. HS.

Family and domain databases

InterProiIPR011333. SKP1/BTB/POZ.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiBTBDG_HUMAN
AccessioniPrimary (citable) accession number: Q32M84
Secondary accession number(s): A6NM63, Q4VXL1, Q96LN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 6, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.