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Protein

Zinc finger protein 699

Gene

ZNF699

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 217C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 699
Alternative name(s):
Hangover homolog
Gene namesi
Name:ZNF699
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196110.7
HGNCiHGNC:24750 ZNF699
MIMi609571 gene
neXtProtiNX_Q32M78

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi374879
OpenTargetsiENSG00000196110
PharmGKBiPA142670496

Polymorphism and mutation databases

BioMutaiZNF699
DMDMi94730691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332791 – 642Zinc finger protein 699Add BLAST642

Proteomic databases

EPDiQ32M78
MaxQBiQ32M78
PaxDbiQ32M78
PeptideAtlasiQ32M78
PRIDEiQ32M78
ProteomicsDBi61593

PTM databases

iPTMnetiQ32M78
PhosphoSitePlusiQ32M78

Expressioni

Gene expression databases

BgeeiENSG00000196110
CleanExiHS_ZNF699

Organism-specific databases

HPAiHPA058287

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-9P604113EBI-10217363,EBI-10172052

Protein-protein interaction databases

BioGridi131929, 3 interactors
IntActiQ32M78, 6 interactors
STRINGi9606.ENSP00000311596

Structurei

3D structure databases

ProteinModelPortaliQ32M78
SMRiQ32M78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 90KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 217C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149035
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ32M78
KOiK09228
OMAiCGKAYNC
OrthoDBiEOG091G02KC
PhylomeDBiQ32M78

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

Q32M78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEERKTAEL QKNRIQDSVV FEDVAVDFTQ EEWALLDLAQ RNLYRDVMLE
60 70 80 90 100
NFQNLASLGY PLHTPHLISQ WEQEEDLQTV KRELIQGIFM GEHREGFETQ
110 120 130 140 150
LKTNESVASQ DICGEKISNE QKIVRFKRND SWFSSLHENQ ESCGIDYQNK
160 170 180 190 200
SHERHLRNHM VENIYECYEE NQDGQTFSQV PNLDSLKRNT EVKSCECHEC
210 220 230 240 250
GKAFVDHSSL KSHIRSHTGS KPYQCKECGK AFHFLACFKK HMKTPTEEKP
260 270 280 290 300
YECKECTKAF SCSSFFRAHM KIHIGKTNYE CKECGKGFSC SSSLTEHKRI
310 320 330 340 350
HSGDKPYECK ECGKAFSCSS SLSKHKRIHS GDKPYECKEC GKAFSSSSHL
360 370 380 390 400
IIHIRIHTGE KPYECKECGK AFSESSKLTV HGRTHTGEKP YKCKECGKAY
410 420 430 440 450
NCPSSLSIHM RKHTGEKPYE CLECGKAFYL PTSLNTHVKN QSREKPYECK
460 470 480 490 500
ECGKAFSCPS SFRAHVRDHT GKIQYECKEC GKTFSRSSSL TEHLRTHSGE
510 520 530 540 550
KPYECKECGK AFISSSHLTV HIRTHTGEKP YECKKCGKAF IYPSALRIHM
560 570 580 590 600
RTHTGEKPYE CKECGKAFRH SSYLTVHARM HTGEKPFECL ECGKAFSCPS
610 620 630 640
SFRRHVRSHT GEKPYECKEC GKAFVCPAYF RRHVKTHTRE NI
Length:642
Mass (Da):73,956
Last modified:December 6, 2005 - v1
Checksum:i6A1F8555234C71B0
GO

Sequence cautioni

The sequence BAC04552 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109267 mRNA Translation: AAI09268.1
BC109268 mRNA Translation: AAI09269.1
AK095463 mRNA Translation: BAC04552.1 Different initiation.
CCDSiCCDS42495.1
RefSeqiNP_940937.1, NM_198535.2
UniGeneiHs.633842

Genome annotation databases

EnsembliENST00000308650; ENSP00000311596; ENSG00000196110
ENST00000591998; ENSP00000467723; ENSG00000196110
GeneIDi374879
KEGGihsa:374879
UCSCiuc002mlc.1 human

Similar proteinsi

Entry informationi

Entry nameiZN699_HUMAN
AccessioniPrimary (citable) accession number: Q32M78
Secondary accession number(s): Q8N9A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 6, 2005
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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