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Protein

Zinc finger protein 699

Gene

ZNF699

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 21723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 699
Alternative name(s):
Hangover homolog
Gene namesi
Name:ZNF699
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24750. ZNF699.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670496.

Polymorphism and mutation databases

BioMutaiZNF699.
DMDMi94730691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Zinc finger protein 699PRO_0000233279Add
BLAST

Proteomic databases

EPDiQ32M78.
PaxDbiQ32M78.
PeptideAtlasiQ32M78.
PRIDEiQ32M78.

PTM databases

iPTMnetiQ32M78.
PhosphoSiteiQ32M78.

Expressioni

Gene expression databases

BgeeiQ32M78.
CleanExiHS_ZNF699.

Organism-specific databases

HPAiHPA058287.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-9P604113EBI-10217363,EBI-10172052

Protein-protein interaction databases

BioGridi131929. 3 interactions.
IntActiQ32M78. 1 interaction.
STRINGi9606.ENSP00000311596.

Structurei

3D structure databases

ProteinModelPortaliQ32M78.
SMRiQ32M78. Positions 19-67, 151-641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 9072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 21723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ32M78.
KOiK09228.
OMAiAYNCPSS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ32M78.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32M78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEERKTAEL QKNRIQDSVV FEDVAVDFTQ EEWALLDLAQ RNLYRDVMLE
60 70 80 90 100
NFQNLASLGY PLHTPHLISQ WEQEEDLQTV KRELIQGIFM GEHREGFETQ
110 120 130 140 150
LKTNESVASQ DICGEKISNE QKIVRFKRND SWFSSLHENQ ESCGIDYQNK
160 170 180 190 200
SHERHLRNHM VENIYECYEE NQDGQTFSQV PNLDSLKRNT EVKSCECHEC
210 220 230 240 250
GKAFVDHSSL KSHIRSHTGS KPYQCKECGK AFHFLACFKK HMKTPTEEKP
260 270 280 290 300
YECKECTKAF SCSSFFRAHM KIHIGKTNYE CKECGKGFSC SSSLTEHKRI
310 320 330 340 350
HSGDKPYECK ECGKAFSCSS SLSKHKRIHS GDKPYECKEC GKAFSSSSHL
360 370 380 390 400
IIHIRIHTGE KPYECKECGK AFSESSKLTV HGRTHTGEKP YKCKECGKAY
410 420 430 440 450
NCPSSLSIHM RKHTGEKPYE CLECGKAFYL PTSLNTHVKN QSREKPYECK
460 470 480 490 500
ECGKAFSCPS SFRAHVRDHT GKIQYECKEC GKTFSRSSSL TEHLRTHSGE
510 520 530 540 550
KPYECKECGK AFISSSHLTV HIRTHTGEKP YECKKCGKAF IYPSALRIHM
560 570 580 590 600
RTHTGEKPYE CKECGKAFRH SSYLTVHARM HTGEKPFECL ECGKAFSCPS
610 620 630 640
SFRRHVRSHT GEKPYECKEC GKAFVCPAYF RRHVKTHTRE NI
Length:642
Mass (Da):73,956
Last modified:December 6, 2005 - v1
Checksum:i6A1F8555234C71B0
GO

Sequence cautioni

The sequence BAC04552.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109267 mRNA. Translation: AAI09268.1.
BC109268 mRNA. Translation: AAI09269.1.
AK095463 mRNA. Translation: BAC04552.1. Different initiation.
CCDSiCCDS42495.1.
RefSeqiNP_940937.1. NM_198535.2.
XP_005259954.1. XM_005259897.2.
UniGeneiHs.633842.

Genome annotation databases

EnsembliENST00000308650; ENSP00000311596; ENSG00000196110.
ENST00000591998; ENSP00000467723; ENSG00000196110.
GeneIDi374879.
KEGGihsa:374879.
UCSCiuc002mlc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109267 mRNA. Translation: AAI09268.1.
BC109268 mRNA. Translation: AAI09269.1.
AK095463 mRNA. Translation: BAC04552.1. Different initiation.
CCDSiCCDS42495.1.
RefSeqiNP_940937.1. NM_198535.2.
XP_005259954.1. XM_005259897.2.
UniGeneiHs.633842.

3D structure databases

ProteinModelPortaliQ32M78.
SMRiQ32M78. Positions 19-67, 151-641.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131929. 3 interactions.
IntActiQ32M78. 1 interaction.
STRINGi9606.ENSP00000311596.

PTM databases

iPTMnetiQ32M78.
PhosphoSiteiQ32M78.

Polymorphism and mutation databases

BioMutaiZNF699.
DMDMi94730691.

Proteomic databases

EPDiQ32M78.
PaxDbiQ32M78.
PeptideAtlasiQ32M78.
PRIDEiQ32M78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308650; ENSP00000311596; ENSG00000196110.
ENST00000591998; ENSP00000467723; ENSG00000196110.
GeneIDi374879.
KEGGihsa:374879.
UCSCiuc002mlc.1. human.

Organism-specific databases

CTDi374879.
GeneCardsiZNF699.
HGNCiHGNC:24750. ZNF699.
HPAiHPA058287.
MIMi609571. gene.
neXtProtiNX_Q32M78.
PharmGKBiPA142670496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ32M78.
KOiK09228.
OMAiAYNCPSS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ32M78.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii374879.
PROiQ32M78.
SOURCEiSearch...

Gene expression databases

BgeeiQ32M78.
CleanExiHS_ZNF699.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-642.

Entry informationi

Entry nameiZN699_HUMAN
AccessioniPrimary (citable) accession number: Q32M78
Secondary accession number(s): Q8N9A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 6, 2005
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.