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Q32M02 (FSCN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fascin-2
Alternative name(s):
Retinal fascin
Gene names
Name:Fscn2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links. Ref.5

Subcellular location

Cytoplasmcytoskeleton. Cell projectionstereocilium. Note: Found mostly in longer hair-cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips. Ref.5

Tissue specificity

Expressed in the inner ear.

Developmental stage

Developmentally regulated, appearing in inner-hair cell stereocilia during final stages of elongation.

Involvement in disease

Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.

Sequence similarities

Belongs to the fascin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Fascin-2
PRO_0000404202

Natural variations

Natural variant1091R → H in prebycusis phenotype; when associated with waltzer cadherin 23 mutant. Ref.5

Experimental info

Sequence conflict3951H → P in BAC34026. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q32M02 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 8B848783E8E778D5

FASTA49255,073
        10         20         30         40         50         60 
MPTNGLHQVL KIQFGLVNDA DRYLTAESFG FKVNASAASL KRKQIWVLEP DPGQGTAVLF 

        70         80         90        100        110        120 
RSSHLGRYLS AEEDGRVACE MDQPGRDCRF LVLPQPDGRW VLQSEPHGRF FGGIEDRLSC 

       130        140        150        160        170        180 
FATAISPAEL WTVHLAIHPQ AHLLSVSRRR YVHLCLQEDE MAADGDMPWG VDALVTLIFQ 

       190        200        210        220        230        240 
SRRYCLKSYD SRYLRSDGRL VWEPEAHACY TLEFKAGKLA FKDCDGRYLA PVGPAGTLKA 

       250        260        270        280        290        300 
GRNTRPSKDE LFDLEQSHPQ VVLVAANRRY ISVRQGINVS ANQDEELGHE TFLMQIDQET 

       310        320        330        340        350        360 
KKCTFYSSTG GYWTLVTHGG IQATATQVSA NTMFEIEWHG RRVALKASNG RFVCMKKNGQ 

       370        380        390        400        410        420 
LAAISDFVGE DELFTLKLIN RPLLVLRGLD GFVCHRRGSN QLDTNRSTYD VFHLSFRDGA 

       430        440        450        460        470        480 
YQIRGRGGGF WYTGSHGSVC SDGDLAEDFL FEFRERGRLA IRALSGKYLR GGASGLLRAD 

       490 
ADLPVGEALW EY 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice."
Shin J.B., Longo-Guess C.M., Gagnon L.H., Saylor K.W., Dumont R.A., Spinelli K.J., Pagana J.M., Wilmarth P.A., David L.L., Gillespie P.G., Johnson K.R.
J. Neurosci. 30:9683-9694(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, VARIANT PREBYCUSIS HIS-109.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK050002 mRNA. Translation: BAC34026.1.
AL669855 Genomic DNA. Translation: CAM27038.1.
CH466558 Genomic DNA. Translation: EDL34739.1.
BC109356 mRNA. Translation: AAI09357.1.
BC109357 mRNA. Translation: AAI09358.1.
RefSeqNP_766390.2. NM_172802.4.
UniGeneMm.481403.

3D structure databases

ProteinModelPortalQ32M02.
SMRQ32M02. Positions 8-492.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ32M02.
PRIDEQ32M02.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026445; ENSMUSP00000026445; ENSMUSG00000025380.
GeneID238021.
KEGGmmu:238021.
UCSCuc007msk.2. mouse.

Organism-specific databases

CTD25794.
MGIMGI:2443337. Fscn2.

Phylogenomic databases

eggNOGNOG85029.
GeneTreeENSGT00530000063373.
HOGENOMHOG000267034.
HOVERGENHBG000968.
InParanoidQ8BWU0.
KOK17455.
OMAYQIRGRG.
OrthoDBEOG7VQJCP.
TreeFamTF323992.

Gene expression databases

BgeeQ32M02.
GenevestigatorQ32M02.

Family and domain databases

InterProIPR008999. Actin_cross-linking.
IPR010431. Fascin.
IPR022768. Fascin-domain.
IPR024703. Fascin_metazoans.
[Graphical view]
PANTHERPTHR10551. PTHR10551. 1 hit.
PfamPF06268. Fascin. 4 hits.
[Graphical view]
PIRSFPIRSF005682. Fascin. 1 hit.
SUPFAMSSF50405. SSF50405. 4 hits.
ProtoNetSearch...

Other

NextBio383636.
PROQ32M02.
SOURCESearch...

Entry information

Entry nameFSCN2_MOUSE
AccessionPrimary (citable) accession number: Q32M02
Secondary accession number(s): Q8BWU0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot