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Q32M02

- FSCN2_MOUSE

UniProt

Q32M02 - FSCN2_MOUSE

Protein

Fascin-2

Gene

Fscn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links.1 Publication

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. actin filament binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. eye photoreceptor cell development Source: MGI

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fascin-2
    Alternative name(s):
    Retinal fascin
    Gene namesi
    Name:Fscn2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2443337. Fscn2.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell projectionstereocilium 1 Publication
    Note: Found mostly in longer hair-cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips.

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. stereocilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Fascin-2PRO_0000404202Add
    BLAST

    Proteomic databases

    PaxDbiQ32M02.
    PRIDEiQ32M02.

    Expressioni

    Tissue specificityi

    Expressed in the inner ear.

    Developmental stagei

    Developmentally regulated, appearing in inner-hair cell stereocilia during final stages of elongation.

    Gene expression databases

    BgeeiQ32M02.
    GenevestigatoriQ32M02.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32M02.
    SMRiQ32M02. Positions 8-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the fascin family.Curated

    Phylogenomic databases

    eggNOGiNOG85029.
    GeneTreeiENSGT00530000063373.
    HOGENOMiHOG000267034.
    HOVERGENiHBG000968.
    InParanoidiQ8BWU0.
    KOiK17455.
    OMAiYQIRGRG.
    OrthoDBiEOG7VQJCP.
    PhylomeDBiQ32M02.
    TreeFamiTF323992.

    Family and domain databases

    InterProiIPR008999. Actin_cross-linking.
    IPR010431. Fascin.
    IPR022768. Fascin-domain.
    IPR024703. Fascin_metazoans.
    [Graphical view]
    PANTHERiPTHR10551. PTHR10551. 1 hit.
    PfamiPF06268. Fascin. 4 hits.
    [Graphical view]
    PIRSFiPIRSF005682. Fascin. 1 hit.
    SUPFAMiSSF50405. SSF50405. 4 hits.

    Sequencei

    Sequence statusi: Complete.

    Q32M02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTNGLHQVL KIQFGLVNDA DRYLTAESFG FKVNASAASL KRKQIWVLEP    50
    DPGQGTAVLF RSSHLGRYLS AEEDGRVACE MDQPGRDCRF LVLPQPDGRW 100
    VLQSEPHGRF FGGIEDRLSC FATAISPAEL WTVHLAIHPQ AHLLSVSRRR 150
    YVHLCLQEDE MAADGDMPWG VDALVTLIFQ SRRYCLKSYD SRYLRSDGRL 200
    VWEPEAHACY TLEFKAGKLA FKDCDGRYLA PVGPAGTLKA GRNTRPSKDE 250
    LFDLEQSHPQ VVLVAANRRY ISVRQGINVS ANQDEELGHE TFLMQIDQET 300
    KKCTFYSSTG GYWTLVTHGG IQATATQVSA NTMFEIEWHG RRVALKASNG 350
    RFVCMKKNGQ LAAISDFVGE DELFTLKLIN RPLLVLRGLD GFVCHRRGSN 400
    QLDTNRSTYD VFHLSFRDGA YQIRGRGGGF WYTGSHGSVC SDGDLAEDFL 450
    FEFRERGRLA IRALSGKYLR GGASGLLRAD ADLPVGEALW EY 492
    Length:492
    Mass (Da):55,073
    Last modified:December 6, 2005 - v1
    Checksum:i8B848783E8E778D5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti395 – 3951H → P in BAC34026. (PubMed:16141072)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091R → H in prebycusis phenotype; when associated with waltzer cadherin 23 mutant. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050002 mRNA. Translation: BAC34026.1.
    AL669855 Genomic DNA. Translation: CAM27038.1.
    CH466558 Genomic DNA. Translation: EDL34739.1.
    BC109356 mRNA. Translation: AAI09357.1.
    BC109357 mRNA. Translation: AAI09358.1.
    CCDSiCCDS25731.1.
    RefSeqiNP_766390.2. NM_172802.4.
    UniGeneiMm.481403.

    Genome annotation databases

    EnsembliENSMUST00000026445; ENSMUSP00000026445; ENSMUSG00000025380.
    GeneIDi238021.
    KEGGimmu:238021.
    UCSCiuc007msk.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050002 mRNA. Translation: BAC34026.1 .
    AL669855 Genomic DNA. Translation: CAM27038.1 .
    CH466558 Genomic DNA. Translation: EDL34739.1 .
    BC109356 mRNA. Translation: AAI09357.1 .
    BC109357 mRNA. Translation: AAI09358.1 .
    CCDSi CCDS25731.1.
    RefSeqi NP_766390.2. NM_172802.4.
    UniGenei Mm.481403.

    3D structure databases

    ProteinModelPortali Q32M02.
    SMRi Q32M02. Positions 8-492.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q32M02.
    PRIDEi Q32M02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026445 ; ENSMUSP00000026445 ; ENSMUSG00000025380 .
    GeneIDi 238021.
    KEGGi mmu:238021.
    UCSCi uc007msk.2. mouse.

    Organism-specific databases

    CTDi 25794.
    MGIi MGI:2443337. Fscn2.

    Phylogenomic databases

    eggNOGi NOG85029.
    GeneTreei ENSGT00530000063373.
    HOGENOMi HOG000267034.
    HOVERGENi HBG000968.
    InParanoidi Q8BWU0.
    KOi K17455.
    OMAi YQIRGRG.
    OrthoDBi EOG7VQJCP.
    PhylomeDBi Q32M02.
    TreeFami TF323992.

    Miscellaneous databases

    NextBioi 383636.
    PROi Q32M02.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q32M02.
    Genevestigatori Q32M02.

    Family and domain databases

    InterProi IPR008999. Actin_cross-linking.
    IPR010431. Fascin.
    IPR022768. Fascin-domain.
    IPR024703. Fascin_metazoans.
    [Graphical view ]
    PANTHERi PTHR10551. PTHR10551. 1 hit.
    Pfami PF06268. Fascin. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF005682. Fascin. 1 hit.
    SUPFAMi SSF50405. SSF50405. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice."
      Shin J.B., Longo-Guess C.M., Gagnon L.H., Saylor K.W., Dumont R.A., Spinelli K.J., Pagana J.M., Wilmarth P.A., David L.L., Gillespie P.G., Johnson K.R.
      J. Neurosci. 30:9683-9694(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, VARIANT PREBYCUSIS HIS-109.

    Entry informationi

    Entry nameiFSCN2_MOUSE
    AccessioniPrimary (citable) accession number: Q32M02
    Secondary accession number(s): Q8BWU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3