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Protein

cAMP-responsive element-binding protein-like 2

Gene

Crebl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of lipid biosynthetic process Source: UniProtKB
  • positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:Crebl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1889385. Crebl2.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181931 – 123cAMP-responsive element-binding protein-like 2Add BLAST123

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ32M00.
PRIDEiQ32M00.

Expressioni

Tissue specificityi

Widely expressed with higher expression in adipose tissue, skeletal muscle, and liver (at protein level).1 Publication

Inductioni

Up-regulated during preadipocyte differentiation (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000032652.
CleanExiMM_CREBL2.

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Creb1Q011474EBI-5314489,EBI-2291098

Protein-protein interaction databases

IntActiQ32M00. 1 interactor.
STRINGi10090.ENSMUSP00000035304.

Structurei

3D structure databases

ProteinModelPortaliQ32M00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 60Basic motifBy similarityAdd BLAST32
Regioni62 – 69Leucine-zipperBy similarity8

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410J0Q3. Eukaryota.
ENOG4111T4Y. LUCA.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiQ32M00.
PhylomeDBiQ32M00.
TreeFamiTF323305.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32M00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQSKP
110 120
QQNSSRHPKA GKTDANTNSL VGN
Length:123
Mass (Da):14,002
Last modified:December 6, 2005 - v1
Checksum:iA1B85B8AA582D62E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103N → S in BAC32383 (PubMed:16141072).Curated1
Sequence conflicti116N → D in BAC32383 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045467 mRNA. Translation: BAC32383.1.
BC109358 mRNA. Translation: AAI09359.1.
BC109359 mRNA. Translation: AAI09360.1.
CCDSiCCDS20640.1.
RefSeqiNP_808355.1. NM_177687.3.
UniGeneiMm.267010.

Genome annotation databases

GeneIDi232430.
KEGGimmu:232430.
UCSCiuc009ekt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045467 mRNA. Translation: BAC32383.1.
BC109358 mRNA. Translation: AAI09359.1.
BC109359 mRNA. Translation: AAI09360.1.
CCDSiCCDS20640.1.
RefSeqiNP_808355.1. NM_177687.3.
UniGeneiMm.267010.

3D structure databases

ProteinModelPortaliQ32M00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ32M00. 1 interactor.
STRINGi10090.ENSMUSP00000035304.

Proteomic databases

PaxDbiQ32M00.
PRIDEiQ32M00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi232430.
KEGGimmu:232430.
UCSCiuc009ekt.1. mouse.

Organism-specific databases

CTDi1389.
MGIiMGI:1889385. Crebl2.

Phylogenomic databases

eggNOGiENOG410J0Q3. Eukaryota.
ENOG4111T4Y. LUCA.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiQ32M00.
PhylomeDBiQ32M00.
TreeFamiTF323305.

Miscellaneous databases

PROiQ32M00.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032652.
CleanExiMM_CREBL2.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBL2_MOUSE
AccessioniPrimary (citable) accession number: Q32M00
Secondary accession number(s): Q8BR67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.