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Protein

Coronin-2A

Gene

CORO2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2A
Gene namesi
Name:CORO2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:27623 CORO2A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782021 – 525Coronin-2AAdd BLAST525

Proteomic databases

PaxDbiQ32LP9
PRIDEiQ32LP9

Expressioni

Gene expression databases

BgeeiENSBTAG00000007659

Interactioni

Subunit structurei

Binds actin. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016014

Structurei

3D structure databases

ProteinModelPortaliQ32LP9
SMRiQ32LP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 120WD 1Add BLAST41
Repeati130 – 170WD 2Add BLAST41
Repeati178 – 217WD 3Add BLAST40
Repeati220 – 263WD 4Add BLAST44
Repeati269 – 308WD 5Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili485 – 524Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ32LP9
KOiK13887
OMAiCRKELVG
OrthoDBiEOG091G03H5
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027335 CORO2A
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF2 PTHR10856:SF2, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q32LP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITHSVQDNHF CAVNPHFIAV
60 70 80 90 100
VTECTGGGAF LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFNDFEIAS
110 120 130 140 150
CSEDATIKIW DIPKQLLTKN LTAFRKELVG HARKVGLVEW HPTAANILFS
160 170 180 190 200
SGYDYKVMVW NLDSKESVIM SPVKTINCHQ DVILSMSFNT NGSLLATACK
210 220 230 240 250
DRKIRVLDPR AGTVLQEANY KGHRANKVLF LGNLKKLLST GTSRWNNRQM
260 270 280 290 300
ALWDQDDLSV PVTEVDLDGS SGVLFPFYDA DTNMLYVVGK GDRNIHYYEI
310 320 330 340 350
SANKPHLNYL MEYHSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI
360 370 380 390 400
EPVSMIVPRR SESYQEDIYP PTASAQPSLT AQEWLSGMNK EPVLMSLRPG
410 420 430 440 450
AEPLSPQPLP SERTLSMPTA PTSPHLFNQT ESLVAEDGRR PFSLLEEKAP
460 470 480 490 500
RWAAEHRQEE KKTWLSDGFD IFECPPPKTE NELLQMFYRQ QDEIRRLREL
510 520
VTQREVQAKQ LELEIRNLRM NSPRL
Length:525
Mass (Da):59,845
Last modified:December 6, 2005 - v1
Checksum:i8FC4B2CB9EFE7CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109477 mRNA Translation: AAI09478.1
RefSeqiNP_001033309.1, NM_001038220.1
UniGeneiBt.28800

Genome annotation databases

EnsembliENSBTAT00000016014; ENSBTAP00000016014; ENSBTAG00000007659
GeneIDi617620
KEGGibta:617620

Similar proteinsi

Entry informationi

Entry nameiCOR2A_BOVIN
AccessioniPrimary (citable) accession number: Q32LP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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