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Protein

Coronin-2A

Gene

CORO2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2A
Gene namesi
Name:CORO2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Coronin-2APRO_0000278202Add
BLAST

Proteomic databases

PaxDbiQ32LP9.
PRIDEiQ32LP9.

Interactioni

Subunit structurei

Binds actin. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016014.

Structurei

3D structure databases

ProteinModelPortaliQ32LP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati80 – 12041WD 1Add
BLAST
Repeati130 – 17041WD 2Add
BLAST
Repeati178 – 21740WD 3Add
BLAST
Repeati220 – 26344WD 4Add
BLAST
Repeati269 – 30840WD 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili485 – 52440Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ32LP9.
KOiK13887.
OMAiKKSWLTN.
OrthoDBiEOG7J70FB.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027335. CORO2A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF2. PTHR10856:SF2. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32LP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITHSVQDNHF CAVNPHFIAV
60 70 80 90 100
VTECTGGGAF LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFNDFEIAS
110 120 130 140 150
CSEDATIKIW DIPKQLLTKN LTAFRKELVG HARKVGLVEW HPTAANILFS
160 170 180 190 200
SGYDYKVMVW NLDSKESVIM SPVKTINCHQ DVILSMSFNT NGSLLATACK
210 220 230 240 250
DRKIRVLDPR AGTVLQEANY KGHRANKVLF LGNLKKLLST GTSRWNNRQM
260 270 280 290 300
ALWDQDDLSV PVTEVDLDGS SGVLFPFYDA DTNMLYVVGK GDRNIHYYEI
310 320 330 340 350
SANKPHLNYL MEYHSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI
360 370 380 390 400
EPVSMIVPRR SESYQEDIYP PTASAQPSLT AQEWLSGMNK EPVLMSLRPG
410 420 430 440 450
AEPLSPQPLP SERTLSMPTA PTSPHLFNQT ESLVAEDGRR PFSLLEEKAP
460 470 480 490 500
RWAAEHRQEE KKTWLSDGFD IFECPPPKTE NELLQMFYRQ QDEIRRLREL
510 520
VTQREVQAKQ LELEIRNLRM NSPRL
Length:525
Mass (Da):59,845
Last modified:December 6, 2005 - v1
Checksum:i8FC4B2CB9EFE7CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109477 mRNA. Translation: AAI09478.1.
RefSeqiNP_001033309.1. NM_001038220.1.
UniGeneiBt.28800.

Genome annotation databases

EnsembliENSBTAT00000016014; ENSBTAP00000016014; ENSBTAG00000007659.
GeneIDi617620.
KEGGibta:617620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109477 mRNA. Translation: AAI09478.1.
RefSeqiNP_001033309.1. NM_001038220.1.
UniGeneiBt.28800.

3D structure databases

ProteinModelPortaliQ32LP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016014.

Proteomic databases

PaxDbiQ32LP9.
PRIDEiQ32LP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016014; ENSBTAP00000016014; ENSBTAG00000007659.
GeneIDi617620.
KEGGibta:617620.

Organism-specific databases

CTDi7464.

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ32LP9.
KOiK13887.
OMAiKKSWLTN.
OrthoDBiEOG7J70FB.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027335. CORO2A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF2. PTHR10856:SF2. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCOR2A_BOVIN
AccessioniPrimary (citable) accession number: Q32LP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.