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Q32LP4

- S4A10_BOVIN

UniProt

Q32LP4 - S4A10_BOVIN

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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

SLC4A10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).By similarity

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:SLC4A10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Localizes to the basolateral membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 508508CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei509 – 52921HelicalSequence AnalysisAdd
BLAST
Topological domaini530 – 5378ExtracellularSequence Analysis
Transmembranei538 – 55821HelicalSequence AnalysisAdd
BLAST
Topological domaini559 – 5613CytoplasmicSequence Analysis
Transmembranei562 – 58221HelicalSequence AnalysisAdd
BLAST
Topological domaini583 – 59513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei596 – 61621HelicalSequence AnalysisAdd
BLAST
Topological domaini617 – 6259CytoplasmicSequence Analysis
Transmembranei626 – 64621HelicalSequence AnalysisAdd
BLAST
Topological domaini647 – 71973ExtracellularSequence AnalysisAdd
BLAST
Transmembranei720 – 74021HelicalSequence AnalysisAdd
BLAST
Topological domaini741 – 76121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei762 – 78221HelicalSequence AnalysisAdd
BLAST
Topological domaini783 – 80826ExtracellularSequence AnalysisAdd
BLAST
Transmembranei809 – 82921HelicalSequence AnalysisAdd
BLAST
Topological domaini830 – 85425CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei855 – 87521HelicalSequence AnalysisAdd
BLAST
Topological domaini876 – 91136ExtracellularSequence AnalysisAdd
BLAST
Transmembranei912 – 93221HelicalSequence AnalysisAdd
BLAST
Topological domaini933 – 9342CytoplasmicSequence Analysis
Transmembranei935 – 95521HelicalSequence AnalysisAdd
BLAST
Topological domaini956 – 99742ExtracellularSequence AnalysisAdd
BLAST
Transmembranei998 – 101821HelicalSequence AnalysisAdd
BLAST
Topological domaini1019 – 111799CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11171117Sodium-driven chloride bicarbonate exchangerPRO_0000245239Add
BLAST

Proteomic databases

PRIDEiQ32LP4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020366.

Structurei

3D structure databases

ProteinModelPortaliQ32LP4.
SMRiQ32LP4. Positions 492-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ32LP4.
KOiK13861.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32LP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSGTCESFQ SLSHQRNDEE AVVDRGGTRS ILKTHFEKED LEGHRTLFIG
60 70 80 90 100
VHVPLGGRKS HRRHRHRGHK HRKRDRERDS GLEDGRESPS FDTPSQRVQF
110 120 130 140 150
ILGTEDDDEE HIPHDLFTEL DEICWREGED AEWRETARWL KFEEDVEDGG
160 170 180 190 200
ERWSKPYVAT LSLHSLFELR SCILNGTVLL DMHANTLEEI ADMVLDQQVS
210 220 230 240 250
SGQLNEDVRH RVHEALMKQH HHQNQKKLTN RIPIVRSFAD IGKKQSEPNS
260 270 280 290 300
MDKNAGQVVS PQSAPACVEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM
310 320 330 340 350
KQRHEKGPPH QQDREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR
360 370 380 390 400
LSPAVLLQGL AEVPIPTRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH
410 420 430 440 450
DVAYKAKDRN DLVSGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK
460 470 480 490 500
IPAVPNGTAA HGEAEPHGGH SGPELQRTGR LFGGLILDIK RKAPYFWSDF
510 520 530 540 550
TDALSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT
560 570 580 590 600
GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT
610 620 630 640 650
ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSEAY
660 670 680 690 700
PINMHNDLEL LTQYSCNCVE PHNPSNNTLK EWRESNISAS DIIWENLTVS
710 720 730 740 750
ECTSLHGEYV GRACGHEHPY VPDVLFWSVI LFFSTVTLSA TLKQFKTSRY
760 770 780 790 800
FPTKVRSIVS DFAVFLTILC MVLIDYAIGI PSPKLQVPSV FKPTRDDRGW
810 820 830 840 850
FVTPLGPNPW WTVIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG
860 870 880 890 900
YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP
910 920 930 940 950
KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK
960 970 980 990 1000
GIQFFDRIKL FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK
1010 1020 1030 1040 1050
VSRAAIVFPM MVLALVFVRK LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE
1060 1070 1080 1090 1100
KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV INISDEMSKT ALWRNLLITA
1110
DNSKDKESSF PSKSSPS
Length:1,117
Mass (Da):125,776
Last modified:December 6, 2005 - v1
Checksum:i5C53EE5C535DC58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109483 mRNA. Translation: AAI09484.1.
RefSeqiNP_001033217.1. NM_001038128.1.
UniGeneiBt.37992.

Genome annotation databases

GeneIDi517077.
KEGGibta:517077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109483 mRNA. Translation: AAI09484.1 .
RefSeqi NP_001033217.1. NM_001038128.1.
UniGenei Bt.37992.

3D structure databases

ProteinModelPortali Q32LP4.
SMRi Q32LP4. Positions 492-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000020366.

Proteomic databases

PRIDEi Q32LP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 517077.
KEGGi bta:517077.

Organism-specific databases

CTDi 57282.

Phylogenomic databases

eggNOGi NOG268067.
HOGENOMi HOG000280684.
HOVERGENi HBG004326.
InParanoidi Q32LP4.
KOi K13861.

Miscellaneous databases

NextBioi 20872371.

Family and domain databases

Gene3Di 3.40.1100.10. 2 hits.
InterProi IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiS4A10_BOVIN
AccessioniPrimary (citable) accession number: Q32LP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3