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Q32LP4 (S4A10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene names
Name:SLC4A10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length1117 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Localizes to the basolateral membrane By similarity.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11171117Sodium-driven chloride bicarbonate exchanger
PRO_0000245239

Regions

Topological domain1 – 508508Cytoplasmic Potential
Transmembrane509 – 52921Helical; Potential
Topological domain530 – 5378Extracellular Potential
Transmembrane538 – 55821Helical; Potential
Topological domain559 – 5613Cytoplasmic Potential
Transmembrane562 – 58221Helical; Potential
Topological domain583 – 59513Extracellular Potential
Transmembrane596 – 61621Helical; Potential
Topological domain617 – 6259Cytoplasmic Potential
Transmembrane626 – 64621Helical; Potential
Topological domain647 – 71973Extracellular Potential
Transmembrane720 – 74021Helical; Potential
Topological domain741 – 76121Cytoplasmic Potential
Transmembrane762 – 78221Helical; Potential
Topological domain783 – 80826Extracellular Potential
Transmembrane809 – 82921Helical; Potential
Topological domain830 – 85425Cytoplasmic Potential
Transmembrane855 – 87521Helical; Potential
Topological domain876 – 91136Extracellular Potential
Transmembrane912 – 93221Helical; Potential
Topological domain933 – 9342Cytoplasmic Potential
Transmembrane935 – 95521Helical; Potential
Topological domain956 – 99742Extracellular Potential
Transmembrane998 – 101821Helical; Potential
Topological domain1019 – 111799Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q32LP4 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 5C53EE5C535DC58F

FASTA1,117125,776
        10         20         30         40         50         60 
MQSGTCESFQ SLSHQRNDEE AVVDRGGTRS ILKTHFEKED LEGHRTLFIG VHVPLGGRKS 

        70         80         90        100        110        120 
HRRHRHRGHK HRKRDRERDS GLEDGRESPS FDTPSQRVQF ILGTEDDDEE HIPHDLFTEL 

       130        140        150        160        170        180 
DEICWREGED AEWRETARWL KFEEDVEDGG ERWSKPYVAT LSLHSLFELR SCILNGTVLL 

       190        200        210        220        230        240 
DMHANTLEEI ADMVLDQQVS SGQLNEDVRH RVHEALMKQH HHQNQKKLTN RIPIVRSFAD 

       250        260        270        280        290        300 
IGKKQSEPNS MDKNAGQVVS PQSAPACVEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM 

       310        320        330        340        350        360 
KQRHEKGPPH QQDREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR LSPAVLLQGL 

       370        380        390        400        410        420 
AEVPIPTRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH DVAYKAKDRN DLVSGIDEFL 

       430        440        450        460        470        480 
DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK IPAVPNGTAA HGEAEPHGGH SGPELQRTGR 

       490        500        510        520        530        540 
LFGGLILDIK RKAPYFWSDF TDALSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA 

       550        560        570        580        590        600 
IESLFGASMT GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT 

       610        620        630        640        650        660 
ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSEAY PINMHNDLEL 

       670        680        690        700        710        720 
LTQYSCNCVE PHNPSNNTLK EWRESNISAS DIIWENLTVS ECTSLHGEYV GRACGHEHPY 

       730        740        750        760        770        780 
VPDVLFWSVI LFFSTVTLSA TLKQFKTSRY FPTKVRSIVS DFAVFLTILC MVLIDYAIGI 

       790        800        810        820        830        840 
PSPKLQVPSV FKPTRDDRGW FVTPLGPNPW WTVIAAIIPA LLCTILIFMD QQITAVIINR 

       850        860        870        880        890        900 
KEHKLKKGCG YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP 

       910        920        930        940        950        960 
KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK GIQFFDRIKL 

       970        980        990       1000       1010       1020 
FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK VSRAAIVFPM MVLALVFVRK 

      1030       1040       1050       1060       1070       1080 
LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV 

      1090       1100       1110 
INISDEMSKT ALWRNLLITA DNSKDKESSF PSKSSPS 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC109483 mRNA. Translation: AAI09484.1.
RefSeqNP_001033217.1. NM_001038128.1.
UniGeneBt.37992.

3D structure databases

ProteinModelPortalQ32LP4.
SMRQ32LP4. Positions 492-532.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000020366.

Proteomic databases

PRIDEQ32LP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID517077.
KEGGbta:517077.

Organism-specific databases

CTD57282.

Phylogenomic databases

eggNOGNOG268067.
HOGENOMHOG000280684.
HOVERGENHBG004326.
InParanoidQ32LP4.
KOK13861.

Family and domain databases

Gene3D3.40.1100.10. 2 hits.
InterProIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
ProtoNetSearch...

Other

NextBio20872371.

Entry information

Entry nameS4A10_BOVIN
AccessionPrimary (citable) accession number: Q32LP4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families