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Q32LP4

- S4A10_BOVIN

UniProt

Q32LP4 - S4A10_BOVIN

Protein

Sodium-driven chloride bicarbonate exchanger

Gene

SLC4A10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity.By similarity

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-driven chloride bicarbonate exchanger
    Alternative name(s):
    Solute carrier family 4 member 10
    Gene namesi
    Name:SLC4A10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: Localizes to the basolateral membrane.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11171117Sodium-driven chloride bicarbonate exchangerPRO_0000245239Add
    BLAST

    Proteomic databases

    PRIDEiQ32LP4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000020366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32LP4.
    SMRiQ32LP4. Positions 492-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 508508CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini530 – 5378ExtracellularSequence Analysis
    Topological domaini559 – 5613CytoplasmicSequence Analysis
    Topological domaini583 – 59513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini617 – 6259CytoplasmicSequence Analysis
    Topological domaini647 – 71973ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini741 – 76121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini783 – 80826ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini830 – 85425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini876 – 91136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini933 – 9342CytoplasmicSequence Analysis
    Topological domaini956 – 99742ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1019 – 111799CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei509 – 52921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei538 – 55821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei562 – 58221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei596 – 61621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei626 – 64621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei720 – 74021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei762 – 78221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei809 – 82921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei855 – 87521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei912 – 93221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei935 – 95521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei998 – 101821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    HOGENOMiHOG000280684.
    HOVERGENiHBG004326.
    InParanoidiQ32LP4.
    KOiK13861.

    Family and domain databases

    Gene3Di3.40.1100.10. 2 hits.
    InterProiIPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q32LP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSGTCESFQ SLSHQRNDEE AVVDRGGTRS ILKTHFEKED LEGHRTLFIG     50
    VHVPLGGRKS HRRHRHRGHK HRKRDRERDS GLEDGRESPS FDTPSQRVQF 100
    ILGTEDDDEE HIPHDLFTEL DEICWREGED AEWRETARWL KFEEDVEDGG 150
    ERWSKPYVAT LSLHSLFELR SCILNGTVLL DMHANTLEEI ADMVLDQQVS 200
    SGQLNEDVRH RVHEALMKQH HHQNQKKLTN RIPIVRSFAD IGKKQSEPNS 250
    MDKNAGQVVS PQSAPACVEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM 300
    KQRHEKGPPH QQDREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR 350
    LSPAVLLQGL AEVPIPTRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH 400
    DVAYKAKDRN DLVSGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK 450
    IPAVPNGTAA HGEAEPHGGH SGPELQRTGR LFGGLILDIK RKAPYFWSDF 500
    TDALSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT 550
    GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT 600
    ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSEAY 650
    PINMHNDLEL LTQYSCNCVE PHNPSNNTLK EWRESNISAS DIIWENLTVS 700
    ECTSLHGEYV GRACGHEHPY VPDVLFWSVI LFFSTVTLSA TLKQFKTSRY 750
    FPTKVRSIVS DFAVFLTILC MVLIDYAIGI PSPKLQVPSV FKPTRDDRGW 800
    FVTPLGPNPW WTVIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG 850
    YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP 900
    KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK 950
    GIQFFDRIKL FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK 1000
    VSRAAIVFPM MVLALVFVRK LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE 1050
    KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV INISDEMSKT ALWRNLLITA 1100
    DNSKDKESSF PSKSSPS 1117
    Length:1,117
    Mass (Da):125,776
    Last modified:December 6, 2005 - v1
    Checksum:i5C53EE5C535DC58F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109483 mRNA. Translation: AAI09484.1.
    RefSeqiNP_001033217.1. NM_001038128.1.
    UniGeneiBt.37992.

    Genome annotation databases

    GeneIDi517077.
    KEGGibta:517077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109483 mRNA. Translation: AAI09484.1 .
    RefSeqi NP_001033217.1. NM_001038128.1.
    UniGenei Bt.37992.

    3D structure databases

    ProteinModelPortali Q32LP4.
    SMRi Q32LP4. Positions 492-532.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000020366.

    Proteomic databases

    PRIDEi Q32LP4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 517077.
    KEGGi bta:517077.

    Organism-specific databases

    CTDi 57282.

    Phylogenomic databases

    eggNOGi NOG268067.
    HOGENOMi HOG000280684.
    HOVERGENi HBG004326.
    InParanoidi Q32LP4.
    KOi K13861.

    Miscellaneous databases

    NextBioi 20872371.

    Family and domain databases

    Gene3Di 3.40.1100.10. 2 hits.
    InterProi IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR003024. Na/HCO3_transpt.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR01231. HCO3TRNSPORT.
    PR01232. NAHCO3TRSPRT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiS4A10_BOVIN
    AccessioniPrimary (citable) accession number: Q32LP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3