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Q32LP4

- S4A10_BOVIN

UniProt

Q32LP4 - S4A10_BOVIN

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Protein
Sodium-driven chloride bicarbonate exchanger
Gene
SLC4A10
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity.

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:SLC4A10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Localizes to the basolateral membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 508508Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei509 – 52921Helical; Reviewed prediction
Add
BLAST
Topological domaini530 – 5378Extracellular Reviewed prediction
Transmembranei538 – 55821Helical; Reviewed prediction
Add
BLAST
Topological domaini559 – 5613Cytoplasmic Reviewed prediction
Transmembranei562 – 58221Helical; Reviewed prediction
Add
BLAST
Topological domaini583 – 59513Extracellular Reviewed prediction
Add
BLAST
Transmembranei596 – 61621Helical; Reviewed prediction
Add
BLAST
Topological domaini617 – 6259Cytoplasmic Reviewed prediction
Transmembranei626 – 64621Helical; Reviewed prediction
Add
BLAST
Topological domaini647 – 71973Extracellular Reviewed prediction
Add
BLAST
Transmembranei720 – 74021Helical; Reviewed prediction
Add
BLAST
Topological domaini741 – 76121Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei762 – 78221Helical; Reviewed prediction
Add
BLAST
Topological domaini783 – 80826Extracellular Reviewed prediction
Add
BLAST
Transmembranei809 – 82921Helical; Reviewed prediction
Add
BLAST
Topological domaini830 – 85425Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei855 – 87521Helical; Reviewed prediction
Add
BLAST
Topological domaini876 – 91136Extracellular Reviewed prediction
Add
BLAST
Transmembranei912 – 93221Helical; Reviewed prediction
Add
BLAST
Topological domaini933 – 9342Cytoplasmic Reviewed prediction
Transmembranei935 – 95521Helical; Reviewed prediction
Add
BLAST
Topological domaini956 – 99742Extracellular Reviewed prediction
Add
BLAST
Transmembranei998 – 101821Helical; Reviewed prediction
Add
BLAST
Topological domaini1019 – 111799Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11171117Sodium-driven chloride bicarbonate exchanger
PRO_0000245239Add
BLAST

Proteomic databases

PRIDEiQ32LP4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020366.

Structurei

3D structure databases

ProteinModelPortaliQ32LP4.
SMRiQ32LP4. Positions 492-532.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ32LP4.
KOiK13861.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32LP4-1 [UniParc]FASTAAdd to Basket

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MQSGTCESFQ SLSHQRNDEE AVVDRGGTRS ILKTHFEKED LEGHRTLFIG     50
VHVPLGGRKS HRRHRHRGHK HRKRDRERDS GLEDGRESPS FDTPSQRVQF 100
ILGTEDDDEE HIPHDLFTEL DEICWREGED AEWRETARWL KFEEDVEDGG 150
ERWSKPYVAT LSLHSLFELR SCILNGTVLL DMHANTLEEI ADMVLDQQVS 200
SGQLNEDVRH RVHEALMKQH HHQNQKKLTN RIPIVRSFAD IGKKQSEPNS 250
MDKNAGQVVS PQSAPACVEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM 300
KQRHEKGPPH QQDREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR 350
LSPAVLLQGL AEVPIPTRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH 400
DVAYKAKDRN DLVSGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK 450
IPAVPNGTAA HGEAEPHGGH SGPELQRTGR LFGGLILDIK RKAPYFWSDF 500
TDALSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT 550
GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT 600
ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSEAY 650
PINMHNDLEL LTQYSCNCVE PHNPSNNTLK EWRESNISAS DIIWENLTVS 700
ECTSLHGEYV GRACGHEHPY VPDVLFWSVI LFFSTVTLSA TLKQFKTSRY 750
FPTKVRSIVS DFAVFLTILC MVLIDYAIGI PSPKLQVPSV FKPTRDDRGW 800
FVTPLGPNPW WTVIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG 850
YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP 900
KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK 950
GIQFFDRIKL FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK 1000
VSRAAIVFPM MVLALVFVRK LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE 1050
KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV INISDEMSKT ALWRNLLITA 1100
DNSKDKESSF PSKSSPS 1117
Length:1,117
Mass (Da):125,776
Last modified:December 6, 2005 - v1
Checksum:i5C53EE5C535DC58F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC109483 mRNA. Translation: AAI09484.1.
RefSeqiNP_001033217.1. NM_001038128.1.
UniGeneiBt.37992.

Genome annotation databases

GeneIDi517077.
KEGGibta:517077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC109483 mRNA. Translation: AAI09484.1 .
RefSeqi NP_001033217.1. NM_001038128.1.
UniGenei Bt.37992.

3D structure databases

ProteinModelPortali Q32LP4.
SMRi Q32LP4. Positions 492-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000020366.

Proteomic databases

PRIDEi Q32LP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 517077.
KEGGi bta:517077.

Organism-specific databases

CTDi 57282.

Phylogenomic databases

eggNOGi NOG268067.
HOGENOMi HOG000280684.
HOVERGENi HBG004326.
InParanoidi Q32LP4.
KOi K13861.

Miscellaneous databases

NextBioi 20872371.

Family and domain databases

Gene3Di 3.40.1100.10. 2 hits.
InterProi IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiS4A10_BOVIN
AccessioniPrimary (citable) accession number: Q32LP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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