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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

SLC4A10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:SLC4A10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 508CytoplasmicSequence analysisAdd BLAST508
Transmembranei509 – 529HelicalSequence analysisAdd BLAST21
Topological domaini530 – 537ExtracellularSequence analysis8
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 561CytoplasmicSequence analysis3
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 595ExtracellularSequence analysisAdd BLAST13
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Topological domaini617 – 625CytoplasmicSequence analysis9
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Topological domaini647 – 719ExtracellularSequence analysisAdd BLAST73
Transmembranei720 – 740HelicalSequence analysisAdd BLAST21
Topological domaini741 – 761CytoplasmicSequence analysisAdd BLAST21
Transmembranei762 – 782HelicalSequence analysisAdd BLAST21
Topological domaini783 – 808ExtracellularSequence analysisAdd BLAST26
Transmembranei809 – 829HelicalSequence analysisAdd BLAST21
Topological domaini830 – 854CytoplasmicSequence analysisAdd BLAST25
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Topological domaini876 – 911ExtracellularSequence analysisAdd BLAST36
Transmembranei912 – 932HelicalSequence analysisAdd BLAST21
Topological domaini933 – 934CytoplasmicSequence analysis2
Transmembranei935 – 955HelicalSequence analysisAdd BLAST21
Topological domaini956 – 997ExtracellularSequence analysisAdd BLAST42
Transmembranei998 – 1018HelicalSequence analysisAdd BLAST21
Topological domaini1019 – 1117CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452391 – 1117Sodium-driven chloride bicarbonate exchangerAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineBy similarity1
Modified residuei93PhosphothreonineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei1056PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ32LP4.
PRIDEiQ32LP4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020366.

Structurei

3D structure databases

ProteinModelPortaliQ32LP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ32LP4.
KOiK13861.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32LP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSGTCESFQ SLSHQRNDEE AVVDRGGTRS ILKTHFEKED LEGHRTLFIG
60 70 80 90 100
VHVPLGGRKS HRRHRHRGHK HRKRDRERDS GLEDGRESPS FDTPSQRVQF
110 120 130 140 150
ILGTEDDDEE HIPHDLFTEL DEICWREGED AEWRETARWL KFEEDVEDGG
160 170 180 190 200
ERWSKPYVAT LSLHSLFELR SCILNGTVLL DMHANTLEEI ADMVLDQQVS
210 220 230 240 250
SGQLNEDVRH RVHEALMKQH HHQNQKKLTN RIPIVRSFAD IGKKQSEPNS
260 270 280 290 300
MDKNAGQVVS PQSAPACVEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM
310 320 330 340 350
KQRHEKGPPH QQDREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR
360 370 380 390 400
LSPAVLLQGL AEVPIPTRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH
410 420 430 440 450
DVAYKAKDRN DLVSGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK
460 470 480 490 500
IPAVPNGTAA HGEAEPHGGH SGPELQRTGR LFGGLILDIK RKAPYFWSDF
510 520 530 540 550
TDALSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT
560 570 580 590 600
GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT
610 620 630 640 650
ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSEAY
660 670 680 690 700
PINMHNDLEL LTQYSCNCVE PHNPSNNTLK EWRESNISAS DIIWENLTVS
710 720 730 740 750
ECTSLHGEYV GRACGHEHPY VPDVLFWSVI LFFSTVTLSA TLKQFKTSRY
760 770 780 790 800
FPTKVRSIVS DFAVFLTILC MVLIDYAIGI PSPKLQVPSV FKPTRDDRGW
810 820 830 840 850
FVTPLGPNPW WTVIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG
860 870 880 890 900
YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP
910 920 930 940 950
KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK
960 970 980 990 1000
GIQFFDRIKL FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK
1010 1020 1030 1040 1050
VSRAAIVFPM MVLALVFVRK LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE
1060 1070 1080 1090 1100
KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV INISDEMSKT ALWRNLLITA
1110
DNSKDKESSF PSKSSPS
Length:1,117
Mass (Da):125,776
Last modified:December 6, 2005 - v1
Checksum:i5C53EE5C535DC58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109483 mRNA. Translation: AAI09484.1.
RefSeqiNP_001033217.1. NM_001038128.1.
UniGeneiBt.37992.

Genome annotation databases

GeneIDi517077.
KEGGibta:517077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109483 mRNA. Translation: AAI09484.1.
RefSeqiNP_001033217.1. NM_001038128.1.
UniGeneiBt.37992.

3D structure databases

ProteinModelPortaliQ32LP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020366.

Proteomic databases

PaxDbiQ32LP4.
PRIDEiQ32LP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi517077.
KEGGibta:517077.

Organism-specific databases

CTDi57282.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ32LP4.
KOiK13861.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS4A10_BOVIN
AccessioniPrimary (citable) accession number: Q32LP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 6, 2005
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.