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Protein

Fermitin family homolog 3

Gene

FERMT3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Fermitin family homolog 3
Alternative name(s):
Kindlin-3
Unc-112-related protein 2
Gene namesi
Name:FERMT3
Synonyms:KIND3, URP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cell projectionpodosome By similarity

  • Note: Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Fermitin family homolog 3PRO_0000254653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphotyrosineBy similarity
Modified residuei502 – 5021PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ32LP0.
PRIDEiQ32LP0.

Interactioni

Subunit structurei

Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055364.

Structurei

3D structure databases

ProteinModelPortaliQ32LP0.
SMRiQ32LP0. Positions 349-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini229 – 556328FERMAdd
BLAST
Domaini354 – 453100PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi147 – 1559Poly-Lys

Domaini

The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

Sequence similaritiesi

Belongs to the kindlin family.Curated
Contains 1 FERM domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3727. Eukaryota.
ENOG410XS1B. LUCA.
HOGENOMiHOG000231715.
HOVERGENiHBG020688.
InParanoidiQ32LP0.
KOiK17084.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50729. SSF50729. 2 hits.
PROSITEiPS00661. FERM_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32LP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGMKTATGD YIDSSWELRV FIGEEDPEAE SLTLRVTGES HIGGVLLKIV
60 70 80 90 100
EEIKRKQDWS DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV
110 120 130 140 150
ILRLPNRRAL RLRASFSQPL FQAMVAICRL LSIRHPEEMS LLRAPEKEKK
160 170 180 190 200
KKKEKEPEEE VYDLTKVVLV GGVAPASFRG MPAHFSDSAQ TEACYHMLSR
210 220 230 240 250
PQPPPDPLLL QRLPRPSSLL DKTQLHSRWL DSSRCLMQQG IKAGDTLWLR
260 270 280 290 300
FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEEIDCTEEE MMVFAALQYH
310 320 330 340 350
INKLSQSGEV DEPAGTDSGL DDLDLALSNL EVKLEGSAPT DMLDSLTTIP
360 370 380 390 400
ELKDHLRIFR PRKLTLKGYR QHWVVFKETT LSYYKSQDEA PGEPIQQLNL
410 420 430 440 450
KGCEVVPDVN VSGQKFCIKL LVPSPEGMSE IYLRCQDEQQ YARWMAGCRL
460 470 480 490 500
ASKGRTMADS SYSSEVQAIL AFLSLQRTGG GGGGSGNHPQ GPDASAEGLN
510 520 530 540 550
PYGLVAPRFQ RKFKAKQLTP RILEAHQNVA QLSLSEAQLR FIQAWQSLPD
560 570 580 590 600
FGISYVVVRF KGSRKDEILG IANNRLIRID LSVGDVVKTW RFSNMRQWNV
610 620 630 640 650
NWDIRQVAIE FDEHINVAFS CVSASCRIVH EYIGGYIFLS TRERARGEEL
660
DEDLFLQLTG GHEAF
Length:665
Mass (Da):75,783
Last modified:December 6, 2005 - v1
Checksum:i3E899F65044101CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109488 mRNA. Translation: AAI09489.1.
RefSeqiNP_001032695.1. NM_001037606.1.
XP_010819463.1. XM_010821161.1.
XP_015325547.1. XM_015470061.1.
UniGeneiBt.2657.

Genome annotation databases

GeneIDi107131138.
525159.
KEGGibta:525159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109488 mRNA. Translation: AAI09489.1.
RefSeqiNP_001032695.1. NM_001037606.1.
XP_010819463.1. XM_010821161.1.
XP_015325547.1. XM_015470061.1.
UniGeneiBt.2657.

3D structure databases

ProteinModelPortaliQ32LP0.
SMRiQ32LP0. Positions 349-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055364.

Proteomic databases

PaxDbiQ32LP0.
PRIDEiQ32LP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107131138.
525159.
KEGGibta:525159.

Organism-specific databases

CTDi83706.

Phylogenomic databases

eggNOGiKOG3727. Eukaryota.
ENOG410XS1B. LUCA.
HOGENOMiHOG000231715.
HOVERGENiHBG020688.
InParanoidiQ32LP0.
KOiK17084.

Miscellaneous databases

NextBioi20874113.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50729. SSF50729. 2 hits.
PROSITEiPS00661. FERM_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiURP2_BOVIN
AccessioniPrimary (citable) accession number: Q32LP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 6, 2005
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.