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Protein

Fermitin family homolog 3

Gene

FERMT3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Fermitin family homolog 3
Alternative name(s):
Kindlin-3
Unc-112-related protein 2
Gene namesi
Name:FERMT3
Synonyms:KIND3, URP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546531 – 665Fermitin family homolog 3Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphotyrosineBy similarity1
Modified residuei502PhosphotyrosineBy similarity1
Modified residuei589PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ32LP0.
PeptideAtlasiQ32LP0.
PRIDEiQ32LP0.

Interactioni

Subunit structurei

Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055364.

Structurei

3D structure databases

ProteinModelPortaliQ32LP0.
SMRiQ32LP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 556FERMAdd BLAST328
Domaini354 – 453PHPROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 155Poly-Lys9

Domaini

The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

Sequence similaritiesi

Belongs to the kindlin family.Curated

Phylogenomic databases

eggNOGiKOG3727. Eukaryota.
ENOG410XS1B. LUCA.
HOGENOMiHOG000231715.
HOVERGENiHBG020688.
InParanoidiQ32LP0.
KOiK17084.

Family and domain databases

CDDicd14473. FERM_B-lobe. 1 hit.
Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00373. FERM_M. 1 hit.
PF00169. PH. 1 hit.
SMARTiView protein in SMART
SM00295. B41. 1 hit.
SM00233. PH. 1 hit.
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS00661. FERM_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32LP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGMKTATGD YIDSSWELRV FIGEEDPEAE SLTLRVTGES HIGGVLLKIV
60 70 80 90 100
EEIKRKQDWS DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV
110 120 130 140 150
ILRLPNRRAL RLRASFSQPL FQAMVAICRL LSIRHPEEMS LLRAPEKEKK
160 170 180 190 200
KKKEKEPEEE VYDLTKVVLV GGVAPASFRG MPAHFSDSAQ TEACYHMLSR
210 220 230 240 250
PQPPPDPLLL QRLPRPSSLL DKTQLHSRWL DSSRCLMQQG IKAGDTLWLR
260 270 280 290 300
FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEEIDCTEEE MMVFAALQYH
310 320 330 340 350
INKLSQSGEV DEPAGTDSGL DDLDLALSNL EVKLEGSAPT DMLDSLTTIP
360 370 380 390 400
ELKDHLRIFR PRKLTLKGYR QHWVVFKETT LSYYKSQDEA PGEPIQQLNL
410 420 430 440 450
KGCEVVPDVN VSGQKFCIKL LVPSPEGMSE IYLRCQDEQQ YARWMAGCRL
460 470 480 490 500
ASKGRTMADS SYSSEVQAIL AFLSLQRTGG GGGGSGNHPQ GPDASAEGLN
510 520 530 540 550
PYGLVAPRFQ RKFKAKQLTP RILEAHQNVA QLSLSEAQLR FIQAWQSLPD
560 570 580 590 600
FGISYVVVRF KGSRKDEILG IANNRLIRID LSVGDVVKTW RFSNMRQWNV
610 620 630 640 650
NWDIRQVAIE FDEHINVAFS CVSASCRIVH EYIGGYIFLS TRERARGEEL
660
DEDLFLQLTG GHEAF
Length:665
Mass (Da):75,783
Last modified:December 6, 2005 - v1
Checksum:i3E899F65044101CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109488 mRNA. Translation: AAI09489.1.
RefSeqiNP_001032695.1. NM_001037606.1.
XP_010819463.1. XM_010821161.1.
XP_015325547.1. XM_015470061.1.
UniGeneiBt.2657.

Genome annotation databases

GeneIDi107131138.
525159.
KEGGibta:107131138.
bta:525159.

Similar proteinsi

Entry informationi

Entry nameiURP2_BOVIN
AccessioniPrimary (citable) accession number: Q32LP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 6, 2005
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families