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Q32LN1

- UBE2H_BOVIN

UniProt

Q32LN1 - UBE2H_BOVIN

Protein

Ubiquitin-conjugating enzyme E2 H

Gene

UBE2H

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K11-linked ubiquitination Source: UniProtKB
    2. protein K48-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 H (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein H
    Ubiquitin-protein ligase H
    Gene namesi
    Name:UBE2H
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Ubiquitin-conjugating enzyme E2 HPRO_0000245038Add
    BLAST

    Proteomic databases

    PRIDEiQ32LN1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000001205.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32LN1.
    SMRiQ32LN1. Positions 4-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00390000004852.
    HOGENOMiHOG000233452.
    HOVERGENiHBG063308.
    InParanoidiQ32LN1.
    KOiK10576.
    OMAiCIESKHE.
    OrthoDBiEOG7Z3F66.
    TreeFamiTF101121.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q32LN1-1 [UniParc]FASTAAdd to Basket

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    MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV    50
    WKVRVDLPDK YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD 100
    LTNIFESFLP QLLAYPNPID PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT 150
    EEALKEQEEG TGDSSSESSM SDFSEDEAQD MEL 183
    Length:183
    Mass (Da):20,655
    Last modified:December 6, 2005 - v1
    Checksum:i3DD5D365945F708C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109502 mRNA. Translation: AAI09503.1.
    RefSeqiNP_001032703.1. NM_001037614.2.
    UniGeneiBt.4543.

    Genome annotation databases

    EnsembliENSBTAT00000001205; ENSBTAP00000001205; ENSBTAG00000000911.
    GeneIDi539313.
    KEGGibta:539313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109502 mRNA. Translation: AAI09503.1 .
    RefSeqi NP_001032703.1. NM_001037614.2.
    UniGenei Bt.4543.

    3D structure databases

    ProteinModelPortali Q32LN1.
    SMRi Q32LN1. Positions 4-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000001205.

    Proteomic databases

    PRIDEi Q32LN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000001205 ; ENSBTAP00000001205 ; ENSBTAG00000000911 .
    GeneIDi 539313.
    KEGGi bta:539313.

    Organism-specific databases

    CTDi 7328.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00390000004852.
    HOGENOMi HOG000233452.
    HOVERGENi HBG063308.
    InParanoidi Q32LN1.
    KOi K10576.
    OMAi CIESKHE.
    OrthoDBi EOG7Z3F66.
    TreeFami TF101121.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 20877911.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiUBE2H_BOVIN
    AccessioniPrimary (citable) accession number: Q32LN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3