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Q32LN1 (UBE2H_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 H

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein H
Ubiquitin-protein ligase H
Gene names
Name:UBE2H
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Ubiquitin-conjugating enzyme E2 H
PRO_0000245038

Sites

Active site871Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q32LN1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 3DD5D365945F708C

FASTA18320,655
        10         20         30         40         50         60 
MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV WKVRVDLPDK 

        70         80         90        100        110        120 
YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD LTNIFESFLP QLLAYPNPID 

       130        140        150        160        170        180 
PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT EEALKEQEEG TGDSSSESSM SDFSEDEAQD 


MEL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC109502 mRNA. Translation: AAI09503.1.
RefSeqNP_001032703.1. NM_001037614.2.
UniGeneBt.4543.

3D structure databases

ProteinModelPortalQ32LN1.
SMRQ32LN1. Positions 4-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000001205.

Proteomic databases

PRIDEQ32LN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001205; ENSBTAP00000001205; ENSBTAG00000000911.
GeneID539313.
KEGGbta:539313.

Organism-specific databases

CTD7328.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00390000004852.
HOGENOMHOG000233452.
HOVERGENHBG063308.
InParanoidQ32LN1.
KOK10576.
OMACIESKHE.
OrthoDBEOG7Z3F66.
TreeFamTF101121.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20877911.

Entry information

Entry nameUBE2H_BOVIN
AccessionPrimary (citable) accession number: Q32LN1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways