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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

SGTA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Gene namesi
Name:SGTA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Small glutamine-rich tetratricopeptide repeat-containing protein alphaPRO_0000333273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei81 – 811PhosphothreonineBy similarity
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei137 – 1371N6-acetyllysineBy similarity
Modified residuei301 – 3011PhosphoserineBy similarity
Modified residuei303 – 3031PhosphothreonineBy similarity
Modified residuei305 – 3051PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ32LM2.

Interactioni

Subunit structurei

Homooligomerize. Interacts with DNAJC5 and DNAJC5B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020081.

Structurei

3D structure databases

ProteinModelPortaliQ32LM2.
SMRiQ32LM2. Positions 86-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati91 – 12434TPR 1Add
BLAST
Repeati125 – 15834TPR 2Add
BLAST
Repeati159 – 19234TPR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 28713Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ32LM2.
KOiK16365.
OMAiEAVAYYR.
OrthoDBiEOG78SQJJ.
TreeFamiTF313092.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32LM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKKRLAYA IIRFLHDQLR HGELSSDAQE SLEVAIQCLE TAFGVTVEDS
60 70 80 90 100
DLALPQTLPE IFEAAAAGKE LPPDLRSPQE TPPSEEDSAE AERLKTEGNE
110 120 130 140 150
QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER
160 170 180 190 200
AICIDPSYSK AYGRMGLALS SLNKHTEAVA YYRKALELDP DNETYKSNLK
210 220 230 240 250
VAELRLREAP SPTGGVGSFD IAGLLNNPSF MSMASNLMNN PQVQQLMSGM
260 270 280 290 300
ISGGHNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR
310
SRTPSASNDD QQE
Length:313
Mass (Da):34,213
Last modified:December 6, 2005 - v1
Checksum:i67075AC382E5D7CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109513 mRNA. Translation: AAI09514.1.
RefSeqiNP_001033119.1. NM_001038030.2.
XP_005209059.1. XM_005209002.3.
XP_010805314.1. XM_010807012.2.
XP_010805315.1. XM_010807013.2.
UniGeneiBt.20203.

Genome annotation databases

EnsembliENSBTAT00000020081; ENSBTAP00000020081; ENSBTAG00000015090.
GeneIDi504701.
KEGGibta:504701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109513 mRNA. Translation: AAI09514.1.
RefSeqiNP_001033119.1. NM_001038030.2.
XP_005209059.1. XM_005209002.3.
XP_010805314.1. XM_010807012.2.
XP_010805315.1. XM_010807013.2.
UniGeneiBt.20203.

3D structure databases

ProteinModelPortaliQ32LM2.
SMRiQ32LM2. Positions 86-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020081.

Proteomic databases

PaxDbiQ32LM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020081; ENSBTAP00000020081; ENSBTAG00000015090.
GeneIDi504701.
KEGGibta:504701.

Organism-specific databases

CTDi6449.

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ32LM2.
KOiK16365.
OMAiEAVAYYR.
OrthoDBiEOG78SQJJ.
TreeFamiTF313092.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiSGTA_BOVIN
AccessioniPrimary (citable) accession number: Q32LM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.