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Protein

Centrin-1

Gene

CETN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity).By similarity

Miscellaneous

Binds two moles of calcium per mole of protein.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521CuratedAdd BLAST12
Calcium bindingi150 – 1612CuratedAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Gene namesi
Name:CETN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:27233 CETN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445571 – 172Centrin-1Add BLAST172

Proteomic databases

PaxDbiQ32LE3
PRIDEiQ32LE3

Expressioni

Gene expression databases

BgeeiENSBTAG00000012320

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052557

Structurei

3D structure databases

ProteinModelPortaliQ32LE3
SMRiQ32LE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the centrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ32LE3
KOiK16465
OMAiEPRKEEM
OrthoDBiEOG091G0RLZ
TreeFamiTF101141

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000629 RNA-helicase_DEAD-box_CS
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q32LE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSYRKPTV ASTSQKRKVG PKPELTEEQK QEVREAFDLF DADGSGTIDV
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK RMIADVDKEG TGKISFNDFL AVMTQKMAEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNED EFLRIMKKTN LY
Length:172
Mass (Da):19,697
Last modified:December 6, 2005 - v1
Checksum:i45731CA62BF720CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109624 mRNA Translation: AAI09625.1
RefSeqiNP_001072974.1, NM_001079506.2
UniGeneiBt.54186

Genome annotation databases

EnsembliENSBTAT00000016356; ENSBTAP00000052557; ENSBTAG00000012320
GeneIDi512850
KEGGibta:512850

Similar proteinsi

Entry informationi

Entry nameiCETN1_BOVIN
AccessioniPrimary (citable) accession number: Q32LE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health