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Protein

Centrin-1

Gene

CETN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi41 – 52121CuratedAdd
BLAST
Calcium bindingi150 – 161122CuratedAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Gene namesi
Name:CETN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Centrin-1PRO_0000244557Add
BLAST

Proteomic databases

PaxDbiQ32LE3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012320.

Interactioni

Subunit structurei

Monomer. Interacts with PIFO.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052557.

Structurei

3D structure databases

ProteinModelPortaliQ32LE3.
SMRiQ32LE3. Positions 24-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 9936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 13636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 17236EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ32LE3.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG091G0RLZ.
TreeFamiTF101141.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32LE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSYRKPTV ASTSQKRKVG PKPELTEEQK QEVREAFDLF DADGSGTIDV
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK RMIADVDKEG TGKISFNDFL AVMTQKMAEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNED EFLRIMKKTN LY
Length:172
Mass (Da):19,697
Last modified:December 6, 2005 - v1
Checksum:i45731CA62BF720CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109624 mRNA. Translation: AAI09625.1.
RefSeqiNP_001072974.1. NM_001079506.2.
UniGeneiBt.54186.

Genome annotation databases

EnsembliENSBTAT00000016356; ENSBTAP00000052557; ENSBTAG00000012320.
GeneIDi512850.
KEGGibta:512850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109624 mRNA. Translation: AAI09625.1.
RefSeqiNP_001072974.1. NM_001079506.2.
UniGeneiBt.54186.

3D structure databases

ProteinModelPortaliQ32LE3.
SMRiQ32LE3. Positions 24-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052557.

Proteomic databases

PaxDbiQ32LE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016356; ENSBTAP00000052557; ENSBTAG00000012320.
GeneIDi512850.
KEGGibta:512850.

Organism-specific databases

CTDi1068.

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ32LE3.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG091G0RLZ.
TreeFamiTF101141.

Gene expression databases

BgeeiENSBTAG00000012320.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCETN1_BOVIN
AccessioniPrimary (citable) accession number: Q32LE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two moles of calcium per mole of protein.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.