ID   GMPR2_BOVIN             Reviewed;         348 AA.
AC   Q32L93;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=GMP reductase 2;
DE            EC=1.7.1.7;
DE   AltName: Full=Guanosine 5'-monophosphate oxidoreductase 2;
DE            Short=Guanosine monophosphate reductase 2;
GN   Name=GMPR2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination
CC       of GMP to IMP. It functions in the conversion of nucleobase,
CC       nucleoside and nucleotide derivatives of G to A nucleotides, and
CC       in maintaining the intracellular balance of A and G nucleotides.
CC       Plays a role in modulating cellular differentiation (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) =
CC       guanosine 5'-phosphate + NADPH.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
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DR   EMBL; BC109695; AAI09696.1; -; mRNA.
DR   IPI; IPI00706578; -.
DR   RefSeq; NP_001033208.1; -.
DR   UniGene; Bt.76123; -.
DR   SMR; Q32L93; 10-337.
DR   Ensembl; ENSBTAG00000002715; Bos taurus.
DR   GeneID; 515837; -.
DR   KEGG; bta:515837; -.
DR   HOVERGEN; Q32L93; -.
DR   BRENDA; 1.7.1.7; 251.
DR   GO; GO:0003920; F:GMP reductase activity; IEA:EC.
DR   GO; GO:0030955; F:potassium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005993; GMP_reduct1.
DR   InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   PIRSF; PIRSF000235; GMP_reductase; 1.
DR   TIGRFAMs; TIGR01305; GMP_reduct_1; 1.
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; NADP; Oxidoreductase; Potassium.
FT   CHAIN         1    348       GMP reductase 2.
FT                                /FTId=PRO_0000253472.
FT   NP_BIND     108    131       NADP (By similarity).
FT   ACT_SITE    186    186       Thioimidate intermediate (By similarity).
FT   METAL       181    181       Potassium; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       183    183       Potassium; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     219    219       NADP (By similarity).
SQ   SEQUENCE   348 AA;  38033 MW;  B4DA9AF8BC5474D2 CRC64;
     MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFAFRN SKQMYTGIPI IAANMDTVGT
     FEMAKVLCKF SLFTAVHKHY SLEQWKEFAS QNPDCLEHLA ASSGTGSSDF EQLEQILNAI
     PQVKYVCLDV ANGYSEHFVE FVKDVRKRFP EHTIMAGNVV TGEMVEELIL SGADIIKVGI
     GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM
     LGGMLAGHSE SGGELIERNG RKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD
     VEHTIRDIIG GIRSTCTYVG AAKQKELSRR TTFIRVTQQV KPIFSDES
//