Reviewed, UniProtKB/Swiss-Prot Q32L93 (GMPR2_BOVIN)

Names and origin

Protein names

Recommended name:
    GMP reductase 2
    EC=1.7.1.7
Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductase 2
      Short name=Guanosine monophosphate reductase 2

Gene names

Name:

GMPR2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation By similarity.
Catalytic activity	Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
Sequence similarities	Belongs to the IMPDH/GMPR family.

Ontologies

Keywords
Ligand	Metal-binding NADP Potassium
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: InterPro potassium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	GMP reductase 2		PRO_0000253472
Regions
	Nucleotide binding	108 – 131	24	NADP By similarity
Sites
	Active site	186	1	Thioimidate intermediate By similarity
	Metal binding	181	1	Potassium; via carbonyl oxygen By similarity
	Metal binding	183	1	Potassium; via carbonyl oxygen By similarity
	Binding site	219	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q32L93-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: B4DA9AF8BC5474D2	FASTA	348	38,033
	10 20 30 40 50 60 MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFAFRN SKQMYTGIPI IAANMDTVGT 70 80 90 100 110 120 FEMAKVLCKF SLFTAVHKHY SLEQWKEFAS QNPDCLEHLA ASSGTGSSDF EQLEQILNAI 130 140 150 160 170 180 PQVKYVCLDV ANGYSEHFVE FVKDVRKRFP EHTIMAGNVV TGEMVEELIL SGADIIKVGI 190 200 210 220 230 240 GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 250 260 270 280 290 300 LGGMLAGHSE SGGELIERNG RKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD 310 320 330 340 VEHTIRDIIG GIRSTCTYVG AAKQKELSRR TTFIRVTQQV KPIFSDES

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC109695 mRNA. Translation: AAI09696.1.
RefSeq	NP_001033208.1.
UniGene	Bt.76123
3D structure databases
SMR	Q32L93. Positions 10-337.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000002715. Bos taurus. [Contig view]
GeneID	515837.
KEGG	bta:515837.
Phylogenomic databases
HOVERGEN	Q32L93.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DHase_GMPRtase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPR2_BOVIN

Accession

Primary (citable) accession number: Q32L93

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	December 6, 2005
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)