Reviewed, UniProtKB/Swiss-Prot Q32L89 (PIGH_BOVIN)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
    EC=2.4.1.198
Alternative name(s):
    Phosphatidylinositol-glycan biosynthesis class H protein
      Short name=PIG-H

Gene names

Name:

PIGH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis By similarity.
Catalytic activity	UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subunit structure	Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PIGH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylinositol N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H		PRO_0000281861
Amino acid modifications
	Modified residue	6	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q32L89-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: E450717E79AB0E48	FASTA	188	21,006
	10 20 30 40 50 60 MEDERSLSDI CGGRLALHRR YYSPSCLEFC LSCPRISLRS ITAVTCTVWL AAYGLFTLCE 70 80 90 100 110 120 NSMILSAAIF ITLLGLLGYL HFVKIDHETL LIIDSLGIQM TSSYASGKES TTFIEMGKVK 130 140 150 160 170 180 DVIINEAIYM QKVIYYLCIL LKDPVEPHGI SQVVPIFQSA KPRLDCLIEV YRSCQEILAH QKAASTSP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC109701 mRNA. Translation: AAI09702.1.
IPI	IPI00713566.
RefSeq	NP_001033205.1.
UniGene	Bt.61756
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q32L89.
Genome annotation databases
Ensembl	ENSBTAT00000024352; ENSBTAP00000024352; ENSBTAG00000018299; Bos taurus. [Genome view]
GeneID	515306.
KEGG	bta:515306.
Organism-specific databases
CTD	515306.
Phylogenomic databases
HOVERGEN	Q32L89.
Enzyme and pathway databases
BRENDA	2.4.1.198. 251.
Family and domain databases
InterPro	IPR019328. GPI-GlcNAc_cplx_Trfase_PIG-H. [Graphical view]
Pfam	PF10181. PIG-H. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PIGH_BOVIN

Accession

Primary (citable) accession number: Q32L89

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	December 6, 2005
Last modified:	September 1, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)