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Protein

Phosphatidate cytidylyltransferase, mitochondrial

Gene

TAMM41

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactori

Mg2+By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)
  3. Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase (CDS1)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase, mitochondrial (EC:2.7.7.41)
Alternative name(s):
CDP-diacylglycerol synthase
Short name:
CDP-DAG synthase
Mitochondrial translocator assembly and maintenance protein 41 homolog
Short name:
TAM41
Gene namesi
Name:TAMM41
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence analysisAdd
BLAST
Chaini25 – 335311Phosphatidate cytidylyltransferase, mitochondrialPRO_0000248353Add
BLAST

Proteomic databases

PaxDbiQ32L81.
PRIDEiQ32L81.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003328.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004316.

Family & Domainsi

Sequence similaritiesi

Belongs to the TAM41 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2986. Eukaryota.
ENOG410ZNKE. LUCA.
HOGENOMiHOG000205225.
HOVERGENiHBG081975.
InParanoidiQ32L81.
KOiK17807.

Family and domain databases

InterProiIPR015222. Mmp37.
[Graphical view]
PANTHERiPTHR13619. PTHR13619. 1 hit.
PfamiPF09139. Mmp37. 1 hit.
[Graphical view]
PIRSFiPIRSF028840. Mmp37. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32L81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQALQSSG VAFRKILSHF PEELSLAFAY GSGVYRQAGP SSDQKNAMLD
60 70 80 90 100
FVFTVDDPWH SKNLKRNWNH YSFLKVLGPR IITAVQNNYG AGVYYNTLIT
110 120 130 140 150
CDGRLIKYGV ISTSVLIEDL LNWNNLYIAG RLQKPVKIVA MNEDVALRSA
160 170 180 190 200
LDQNLKSAVT AAFLMLPESF SEEDLFTEIA GLSYSGDFRM VVGEDKAKVL
210 220 230 240 250
NIVKPNMAHF RELYGSILQE SPQVVYKAQQ GSLEIDKSPE GQFTQLMTLP
260 270 280 290 300
KTLQQQINHI MDPPGKNRDV EETLLQVAHD PDCGDVVRLG LAAIVRPSSM
310 320 330
RQSTKGIFTA GLKKSVVYSS LKLHKMWKGW VRKTS
Length:335
Mass (Da):37,420
Last modified:December 6, 2005 - v1
Checksum:iAA84ADCDAC4511B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109718 mRNA. Translation: AAI09719.1.
RefSeqiNP_001073242.1. NM_001079774.1.
UniGeneiBt.25402.

Genome annotation databases

GeneIDi514330.
KEGGibta:514330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109718 mRNA. Translation: AAI09719.1.
RefSeqiNP_001073242.1. NM_001079774.1.
UniGeneiBt.25402.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004316.

Proteomic databases

PaxDbiQ32L81.
PRIDEiQ32L81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514330.
KEGGibta:514330.

Organism-specific databases

CTDi132001.

Phylogenomic databases

eggNOGiKOG2986. Eukaryota.
ENOG410ZNKE. LUCA.
HOGENOMiHOG000205225.
HOVERGENiHBG081975.
InParanoidiQ32L81.
KOiK17807.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Gene expression databases

BgeeiENSBTAG00000003328.

Family and domain databases

InterProiIPR015222. Mmp37.
[Graphical view]
PANTHERiPTHR13619. PTHR13619. 1 hit.
PfamiPF09139. Mmp37. 1 hit.
[Graphical view]
PIRSFiPIRSF028840. Mmp37. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAM41_BOVIN
AccessioniPrimary (citable) accession number: Q32L81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.