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Protein

Glutaredoxin-2, mitochondrial

Gene

GLRX2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity).By similarity

Enzyme regulationi

The 2Fe-2S present in the homodimer leads to inactivation of the enzyme. The 2Fe-2S may serve as a redox sensor: the presence of one-electron oxidants or reductants leading to the loss of the 2Fe-2S cluster, subsequent monomerization and activation of the enzyme (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Iron-sulfur (2Fe-2S); shared with dimeric partner; in inactive formBy similarity1
Binding sitei68GlutathioneBy similarity1
Binding sitei103GlutathioneBy similarity1
Binding sitei115Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi147Iron-sulfur (2Fe-2S); shared with dimeric partner; in inactive formBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-2, mitochondrial
Gene namesi
Name:GLRX2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:29416 GLRX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000032662819 – 157Glutaredoxin-2, mitochondrialAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineBy similarity1
Disulfide bondi71 ↔ 74Redox-active; alternateBy similarity
Modified residuei71S-glutathionyl cysteine; alternateBy similarity1

Keywords - PTMi

Disulfide bond, Glutathionylation, Phosphoprotein

Proteomic databases

PaxDbiQ32L67

Expressioni

Gene expression databases

BgeeiENSBTAG00000015972

Interactioni

Subunit structurei

Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021249

Structurei

3D structure databases

ProteinModelPortaliQ32L67
SMRiQ32L67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 151GlutaredoxinPROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141123
HOGENOMiHOG000095204
HOVERGENiHBG096801
InParanoidiQ32L67
KOiK03676
OMAiDMLEYGS
OrthoDBiEOG091G0WLY
TreeFamiTF319627

Family and domain databases

InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32L67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYWRRAALVG TRLIPVRSSS AGRLEGPAGI SGSGMGNSTS SSLGNAATAP
60 70 80 90 100
VNQIQETISN NCVVIFSKTS CSYCTMAKNL FHDMNVNYKV VELDMLEYGS
110 120 130 140 150
QFQDALHKMT GERTVPRIFV NGTFIGGATD THRLHKEGKL LPLVHQCHLK

NSKREEL
Length:157
Mass (Da):17,202
Last modified:December 6, 2005 - v1
Checksum:i3106F9214733EFD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109742 mRNA Translation: AAI09743.1
RefSeqiNP_001035613.1, NM_001040523.2
XP_005216824.1, XM_005216767.3
XP_010811391.1, XM_010813089.2
UniGeneiBt.27603

Genome annotation databases

EnsembliENSBTAT00000021249; ENSBTAP00000021249; ENSBTAG00000015972
GeneIDi513762
KEGGibta:513762

Similar proteinsi

Entry informationi

Entry nameiGLRX2_BOVIN
AccessioniPrimary (citable) accession number: Q32L67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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