Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q32L27 (UB2Q2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 Q2

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein Q2
Ubiquitin-protein ligase Q2
Gene names
Name:UBE2Q2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein K48-linked ubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Ubiquitin-conjugating enzyme E2 Q2
PRO_0000223878

Regions

Compositional bias41 – 5515Pro-rich
Compositional bias102 – 14544Glu-rich

Sites

Active site2711Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q32L27 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 5BB0CFBD4222BA51

FASTA34238,717
        10         20         30         40         50         60 
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH SPPPPLTLHC 

        70         80         90        100        110        120 
NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT TEEVTSEEEE EEEMAEDIED 

       130        140        150        160        170        180 
LDHYEMKEEE PISGKKSEDE GIEKENLAIL EKIRKTQRQD HLNGAVSGSV QASDRLMKEL 

       190        200        210        220        230        240 
RDIYRSQSYK TGIYSVELIN DSLYDWHVKL QKVDPDSPLH SDLQILKEKE GIEYILLNFS 

       250        260        270        280        290        300 
FKDNFPFDPP FVRVVLPVLS GGYVLGGGAL CMELLTKQGW SSAYSIESVI MQINATLVKG 

       310        320        330        340 
KARVQFGANK NQYNLARAQQ SYNSIVQIHE KNGWYTPPKE DG 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC109798 mRNA. Translation: AAI09799.1.
RefSeqNP_001068998.1. NM_001075530.2.
UniGeneBt.53371.

3D structure databases

ProteinModelPortalQ32L27.
SMRQ32L27. Positions 168-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000005253.

Proteomic databases

PRIDEQ32L27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000005257; ENSBTAP00000005257; ENSBTAG00000004024.
GeneID511631.
KEGGbta:511631.

Organism-specific databases

CTD92912.

Phylogenomic databases

eggNOGNOG320521.
GeneTreeENSGT00390000018573.
HOGENOMHOG000007757.
HOVERGENHBG061368.
KOK10582.
OMASYKAGIY.
OrthoDBEOG76DTSS.
TreeFamTF313338.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR006575. RWD-domain.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF05773. RWD. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 2 hits.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870026.

Entry information

Entry nameUB2Q2_BOVIN
AccessionPrimary (citable) accession number: Q32L27
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways