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Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

UBE2Q2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei271 – 2711Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ligase activity Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Q2
Ubiquitin-protein ligase Q2
Gene namesi
Name:UBE2Q2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 21

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Ubiquitin-conjugating enzyme E2 Q2PRO_0000223878Add
BLAST

Proteomic databases

PRIDEiQ32L27.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005253.

Structurei

3D structure databases

ProteinModelPortaliQ32L27.
SMRiQ32L27. Positions 168-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 5515Pro-richAdd
BLAST
Compositional biasi102 – 14544Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ32L27.
KOiK10582.
OMAiSPLRCEQ.
OrthoDBiEOG76DTSS.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32L27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH
60 70 80 90 100
SPPPPLTLHC NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT
110 120 130 140 150
TEEVTSEEEE EEEMAEDIED LDHYEMKEEE PISGKKSEDE GIEKENLAIL
160 170 180 190 200
EKIRKTQRQD HLNGAVSGSV QASDRLMKEL RDIYRSQSYK TGIYSVELIN
210 220 230 240 250
DSLYDWHVKL QKVDPDSPLH SDLQILKEKE GIEYILLNFS FKDNFPFDPP
260 270 280 290 300
FVRVVLPVLS GGYVLGGGAL CMELLTKQGW SSAYSIESVI MQINATLVKG
310 320 330 340
KARVQFGANK NQYNLARAQQ SYNSIVQIHE KNGWYTPPKE DG
Length:342
Mass (Da):38,717
Last modified:December 6, 2005 - v1
Checksum:i5BB0CFBD4222BA51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109798 mRNA. Translation: AAI09799.1.
RefSeqiNP_001068998.1. NM_001075530.2.
UniGeneiBt.53371.

Genome annotation databases

EnsembliENSBTAT00000005257; ENSBTAP00000005257; ENSBTAG00000004024.
GeneIDi511631.
KEGGibta:511631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109798 mRNA. Translation: AAI09799.1.
RefSeqiNP_001068998.1. NM_001075530.2.
UniGeneiBt.53371.

3D structure databases

ProteinModelPortaliQ32L27.
SMRiQ32L27. Positions 168-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005253.

Proteomic databases

PRIDEiQ32L27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005257; ENSBTAP00000005257; ENSBTAG00000004024.
GeneIDi511631.
KEGGibta:511631.

Organism-specific databases

CTDi92912.

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ32L27.
KOiK10582.
OMAiSPLRCEQ.
OrthoDBiEOG76DTSS.
TreeFamiTF313338.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi20870026.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiUB2Q2_BOVIN
AccessioniPrimary (citable) accession number: Q32L27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 6, 2005
Last modified: March 4, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.