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Q32L27

- UB2Q2_BOVIN

UniProt

Q32L27 - UB2Q2_BOVIN

Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

UBE2Q2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei271 – 2711Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein Q2
    Ubiquitin-protein ligase Q2
    Gene namesi
    Name:UBE2Q2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 21

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Ubiquitin-conjugating enzyme E2 Q2PRO_0000223878Add
    BLAST

    Proteomic databases

    PRIDEiQ32L27.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000005253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32L27.
    SMRiQ32L27. Positions 168-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 5515Pro-richAdd
    BLAST
    Compositional biasi102 – 14544Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320521.
    GeneTreeiENSGT00390000018573.
    HOGENOMiHOG000007757.
    HOVERGENiHBG061368.
    KOiK10582.
    OMAiSYKAGIY.
    OrthoDBiEOG76DTSS.
    TreeFamiTF313338.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR006575. RWD-domain.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF05773. RWD. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 2 hits.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q32L27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH    50
    SPPPPLTLHC NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT 100
    TEEVTSEEEE EEEMAEDIED LDHYEMKEEE PISGKKSEDE GIEKENLAIL 150
    EKIRKTQRQD HLNGAVSGSV QASDRLMKEL RDIYRSQSYK TGIYSVELIN 200
    DSLYDWHVKL QKVDPDSPLH SDLQILKEKE GIEYILLNFS FKDNFPFDPP 250
    FVRVVLPVLS GGYVLGGGAL CMELLTKQGW SSAYSIESVI MQINATLVKG 300
    KARVQFGANK NQYNLARAQQ SYNSIVQIHE KNGWYTPPKE DG 342
    Length:342
    Mass (Da):38,717
    Last modified:December 6, 2005 - v1
    Checksum:i5BB0CFBD4222BA51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109798 mRNA. Translation: AAI09799.1.
    RefSeqiNP_001068998.1. NM_001075530.2.
    UniGeneiBt.53371.

    Genome annotation databases

    EnsembliENSBTAT00000005257; ENSBTAP00000005257; ENSBTAG00000004024.
    GeneIDi511631.
    KEGGibta:511631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109798 mRNA. Translation: AAI09799.1 .
    RefSeqi NP_001068998.1. NM_001075530.2.
    UniGenei Bt.53371.

    3D structure databases

    ProteinModelPortali Q32L27.
    SMRi Q32L27. Positions 168-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000005253.

    Proteomic databases

    PRIDEi Q32L27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000005257 ; ENSBTAP00000005257 ; ENSBTAG00000004024 .
    GeneIDi 511631.
    KEGGi bta:511631.

    Organism-specific databases

    CTDi 92912.

    Phylogenomic databases

    eggNOGi NOG320521.
    GeneTreei ENSGT00390000018573.
    HOGENOMi HOG000007757.
    HOVERGENi HBG061368.
    KOi K10582.
    OMAi SYKAGIY.
    OrthoDBi EOG76DTSS.
    TreeFami TF313338.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 20870026.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR006575. RWD-domain.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF05773. RWD. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 2 hits.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiUB2Q2_BOVIN
    AccessioniPrimary (citable) accession number: Q32L27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3