Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q32L27 (UB2Q2_BOVIN)

Last modified November 25, 2008. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ubiquitin-conjugating enzyme E2 Q2
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase Q2
    Ubiquitin carrier protein Q2
Gene names
Name: UBE2Q2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Ubiquitin-conjugating enzyme E2 Q2
PRO_0000223878

Regions

Compositional bias41 – 5515Pro-rich
Compositional bias102 – 14544Glu-rich

Sites

Active site2711Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue3361Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q32L27-1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 5BB0CFBD4222BA51

FASTA34238,717
        10         20         30         40         50         60 
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH SPPPPLTLHC 

        70         80         90        100        110        120 
NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT TEEVTSEEEE EEEMAEDIED 

       130        140        150        160        170        180 
LDHYEMKEEE PISGKKSEDE GIEKENLAIL EKIRKTQRQD HLNGAVSGSV QASDRLMKEL 

       190        200        210        220        230        240 
RDIYRSQSYK TGIYSVELIN DSLYDWHVKL QKVDPDSPLH SDLQILKEKE GIEYILLNFS 

       250        260        270        280        290        300 
FKDNFPFDPP FVRVVLPVLS GGYVLGGGAL CMELLTKQGW SSAYSIESVI MQINATLVKG 

       310        320        330        340 
KARVQFGANK NQYNLARAQQ SYNSIVQIHE KNGWYTPPKE DG 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

BC109798 mRNA. Translation: AAI09799.1.
RefSeqNP_001068998.1.
UniGeneBt.53371

3D structure databases

SMRQ32L27. Positions 168-329.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000004024. Bos taurus. [Contig view]
GeneID511631.
KEGGbta:511631.

Phylogenomic databases

HOVERGENQ32L27.

Family and domain databases

InterProIPR006575. RWD.
IPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHERPTHR11621. UBQ-conjugat_E2. 1 hit.
PfamPF05773. RWD. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. False negative.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUB2Q2_BOVIN
AccessionPrimary (citable) accession number: Q32L27
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 6, 2005
Last modified: November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents