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Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

UBE2Q2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei271Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme Q2
Ubiquitin carrier protein Q2
Ubiquitin-protein ligase Q2
Gene namesi
Name:UBE2Q2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:36593 UBE2Q2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002238781 – 342Ubiquitin-conjugating enzyme E2 Q2Add BLAST342

Post-translational modificationi

Auto-ubiquitinated in vitro.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ32L27
PRIDEiQ32L27

Expressioni

Gene expression databases

BgeeiENSBTAG00000004024

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005257

Structurei

3D structure databases

ProteinModelPortaliQ32L27
SMRiQ32L27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 55Pro-richAdd BLAST15
Compositional biasi102 – 145Glu-richAdd BLAST44

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0897 Eukaryota
ENOG410XRET LUCA
GeneTreeiENSGT00390000018573
HOGENOMiHOG000007757
HOVERGENiHBG061368
InParanoidiQ32L27
KOiK10582
OMAiIPTGQNG
OrthoDBiEOG091G0LGG
TreeFamiTF313338

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.102 hits
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 2 hits
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q32L27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH
60 70 80 90 100
SPPPPLTLHC NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT
110 120 130 140 150
TEEVTSEEEE EEEMAEDIED LDHYEMKEEE PISGKKSEDE GIEKENLAIL
160 170 180 190 200
EKIRKTQRQD HLNGAVSGSV QASDRLMKEL RDIYRSQSYK TGIYSVELIN
210 220 230 240 250
DSLYDWHVKL QKVDPDSPLH SDLQILKEKE GIEYILLNFS FKDNFPFDPP
260 270 280 290 300
FVRVVLPVLS GGYVLGGGAL CMELLTKQGW SSAYSIESVI MQINATLVKG
310 320 330 340
KARVQFGANK NQYNLARAQQ SYNSIVQIHE KNGWYTPPKE DG
Length:342
Mass (Da):38,717
Last modified:December 6, 2005 - v1
Checksum:i5BB0CFBD4222BA51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109798 mRNA Translation: AAI09799.1
RefSeqiNP_001068998.1, NM_001075530.2
UniGeneiBt.53371

Genome annotation databases

EnsembliENSBTAT00000005257; ENSBTAP00000005257; ENSBTAG00000004024
GeneIDi511631
KEGGibta:511631

Similar proteinsi

Entry informationi

Entry nameiUB2Q2_BOVIN
AccessioniPrimary (citable) accession number: Q32L27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome