ID   IF3M_BOVIN              Reviewed;         273 AA.
AC   Q32KZ1;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   24-JAN-2024, entry version 104.
DE   RecName: Full=Translation initiation factor IF-3, mitochondrial;
DE            Short=IF-3(Mt);
DE            Short=IF-3Mt;
DE            Short=IF3(mt);
DE            Short=IF3mt;
DE   Flags: Precursor;
GN   Name=MTIF3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: IF-3 binds to the 28S ribosomal subunit and shifts the
CC       equilibrium between 55S ribosomes and their 39S and 28S subunits in
CC       favor of the free subunits, thus enhancing the availability of 28S
CC       subunits on which protein synthesis initiation begins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000305}.
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DR   EMBL; BC109845; AAI09846.1; -; mRNA.
DR   RefSeq; NP_001033155.1; NM_001038066.2.
DR   RefSeq; XP_005213827.1; XM_005213770.3.
DR   RefSeq; XP_005213829.1; XM_005213772.3.
DR   RefSeq; XP_005213830.1; XM_005213773.3.
DR   RefSeq; XP_015329307.1; XM_015473821.1.
DR   AlphaFoldDB; Q32KZ1; -.
DR   SMR; Q32KZ1; -.
DR   STRING; 9913.ENSBTAP00000027352; -.
DR   PaxDb; 9913-ENSBTAP00000027352; -.
DR   GeneID; 509987; -.
DR   KEGG; bta:509987; -.
DR   CTD; 219402; -.
DR   eggNOG; ENOG502SBZS; Eukaryota.
DR   HOGENOM; CLU_086230_0_1_1; -.
DR   InParanoid; Q32KZ1; -.
DR   TreeFam; TF332326; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; TAS:Reactome.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0043024; F:ribosomal small subunit binding; ISS:BHF-UCL.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0008135; F:translation factor activity, RNA binding; ISS:BHF-UCL.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0070124; P:mitochondrial translational initiation; ISS:BHF-UCL.
DR   GO; GO:0032790; P:ribosome disassembly; ISS:BHF-UCL.
DR   Gene3D; 3.30.110.10; Translation initiation factor 3 (IF-3), C-terminal domain; 1.
DR   Gene3D; 3.10.20.80; Translation initiation factor 3 (IF-3), N-terminal domain; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   PANTHER; PTHR10938; TRANSLATION INITIATION FACTOR IF-3; 1.
DR   PANTHER; PTHR10938:SF0; TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF55200; Translation initiation factor IF3, C-terminal domain; 1.
DR   SUPFAM; SSF54364; Translation initiation factor IF3, N-terminal domain; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Mitochondrion; Protein biosynthesis; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..32
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   PROPEP          33..92
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000280034"
FT   CHAIN           93..273
FT                   /note="Translation initiation factor IF-3, mitochondrial"
FT                   /id="PRO_0000280035"
FT   REGION          242..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   273 AA;  30619 MW;  FA50E18C558875BF CRC64;
     MAALFLKKLT LQTVKTENYC IRRCLGKYIL QGPAPTQQPP RPSCLIHAKA FSTEDTQDEM
     TKKKKNETAF SSVGRKINER IIHVLDEQGN DLGHMHRANV IRLMAERDLR LVKRDASAEP
     PQYQLLTGAQ IHQERLRLRE AERAAPKPGP TLTKELTFSS NIGQHDLDTK SKQIQQWIEK
     KYKVQITVKK GKSADEPEDK MEEMCNRIVQ TMSGIATFSS RPQPIRGGKA VMCVLRPLSK
     KEEAAWKAAP DTPRRDALNG GDGKDGASGV LPQ
//