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Q32KZ1

- IF3M_BOVIN

UniProt

Q32KZ1 - IF3M_BOVIN

Protein

Translation initiation factor IF-3, mitochondrial

Gene

MTIF3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.By similarity

    GO - Molecular functioni

    1. ribosomal small subunit binding Source: BHF-UCL
    2. translation factor activity, nucleic acid binding Source: BHF-UCL
    3. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. formation of translation initiation complex Source: BHF-UCL
    2. regulation of translational initiation Source: BHF-UCL
    3. ribosome disassembly Source: BHF-UCL

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-3, mitochondrial
    Short name:
    IF-3(Mt)
    Short name:
    IF-3Mt
    Short name:
    IF3(mt)
    Short name:
    IF3mt
    Gene namesi
    Name:MTIF3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 12

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: BHF-UCL

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3232MitochondrionBy similarityAdd
    BLAST
    Propeptidei33 – 9260Removed in mature formBy similarityPRO_0000280034Add
    BLAST
    Chaini93 – 273181Translation initiation factor IF-3, mitochondrialPRO_0000280035Add
    BLAST

    Proteomic databases

    PRIDEiQ32KZ1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000027352.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32KZ1.
    SMRiQ32KZ1. Positions 144-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 654Poly-Lys

    Sequence similaritiesi

    Belongs to the IF-3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG87881.
    GeneTreeiENSGT00390000014424.
    HOGENOMiHOG000264227.
    HOVERGENiHBG080563.
    InParanoidiQ32KZ1.
    KOiK02520.
    OMAiQTMPGIA.
    OrthoDBiEOG7DZ8KV.
    TreeFamiTF332326.

    Family and domain databases

    Gene3Di3.10.20.80. 1 hit.
    3.30.110.10. 1 hit.
    InterProiIPR001288. Translation_initiation_fac_3.
    IPR019815. Translation_initiation_fac_3_C.
    IPR019814. Translation_initiation_fac_3_N.
    [Graphical view]
    PANTHERiPTHR10938. PTHR10938. 1 hit.
    PfamiPF00707. IF3_C. 1 hit.
    PF05198. IF3_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54364. SSF54364. 1 hit.
    SSF55200. SSF55200. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q32KZ1-1 [UniParc]FASTAAdd to Basket

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    MAALFLKKLT LQTVKTENYC IRRCLGKYIL QGPAPTQQPP RPSCLIHAKA    50
    FSTEDTQDEM TKKKKNETAF SSVGRKINER IIHVLDEQGN DLGHMHRANV 100
    IRLMAERDLR LVKRDASAEP PQYQLLTGAQ IHQERLRLRE AERAAPKPGP 150
    TLTKELTFSS NIGQHDLDTK SKQIQQWIEK KYKVQITVKK GKSADEPEDK 200
    MEEMCNRIVQ TMSGIATFSS RPQPIRGGKA VMCVLRPLSK KEEAAWKAAP 250
    DTPRRDALNG GDGKDGASGV LPQ 273
    Length:273
    Mass (Da):30,619
    Last modified:December 6, 2005 - v1
    Checksum:iFA50E18C558875BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109845 mRNA. Translation: AAI09846.1.
    RefSeqiNP_001033155.1. NM_001038066.2.
    XP_005213827.1. XM_005213770.1.
    XP_005213828.1. XM_005213771.1.
    XP_005213829.1. XM_005213772.1.
    XP_005213830.1. XM_005213773.1.
    UniGeneiBt.30788.

    Genome annotation databases

    EnsembliENSBTAT00000027352; ENSBTAP00000027352; ENSBTAG00000020530.
    GeneIDi509987.
    KEGGibta:509987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109845 mRNA. Translation: AAI09846.1 .
    RefSeqi NP_001033155.1. NM_001038066.2.
    XP_005213827.1. XM_005213770.1.
    XP_005213828.1. XM_005213771.1.
    XP_005213829.1. XM_005213772.1.
    XP_005213830.1. XM_005213773.1.
    UniGenei Bt.30788.

    3D structure databases

    ProteinModelPortali Q32KZ1.
    SMRi Q32KZ1. Positions 144-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000027352.

    Proteomic databases

    PRIDEi Q32KZ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000027352 ; ENSBTAP00000027352 ; ENSBTAG00000020530 .
    GeneIDi 509987.
    KEGGi bta:509987.

    Organism-specific databases

    CTDi 219402.

    Phylogenomic databases

    eggNOGi NOG87881.
    GeneTreei ENSGT00390000014424.
    HOGENOMi HOG000264227.
    HOVERGENi HBG080563.
    InParanoidi Q32KZ1.
    KOi K02520.
    OMAi QTMPGIA.
    OrthoDBi EOG7DZ8KV.
    TreeFami TF332326.

    Miscellaneous databases

    NextBioi 20869232.

    Family and domain databases

    Gene3Di 3.10.20.80. 1 hit.
    3.30.110.10. 1 hit.
    InterProi IPR001288. Translation_initiation_fac_3.
    IPR019815. Translation_initiation_fac_3_C.
    IPR019814. Translation_initiation_fac_3_N.
    [Graphical view ]
    PANTHERi PTHR10938. PTHR10938. 1 hit.
    Pfami PF00707. IF3_C. 1 hit.
    PF05198. IF3_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54364. SSF54364. 1 hit.
    SSF55200. SSF55200. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiIF3M_BOVIN
    AccessioniPrimary (citable) accession number: Q32KZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3