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Protein

Translation initiation factor IF-3, mitochondrial

Gene

MTIF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.By similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrial translational initiation Source: BHF-UCL
  • ribosome disassembly Source: BHF-UCL

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-3, mitochondrial
Short name:
IF-3(Mt)
Short name:
IF-3Mt
Short name:
IF3(mt)
Short name:
IF3mt
Gene namesi
Name:MTIF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:31734 MTIF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionBy similarityAdd BLAST32
PropeptideiPRO_000028003433 – 92Removed in mature formBy similarityAdd BLAST60
ChainiPRO_000028003593 – 273Translation initiation factor IF-3, mitochondrialAdd BLAST181

Proteomic databases

PaxDbiQ32KZ1
PRIDEiQ32KZ1

Expressioni

Gene expression databases

BgeeiENSBTAG00000020530

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027352

Structurei

3D structure databases

ProteinModelPortaliQ32KZ1
SMRiQ32KZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 65Poly-Lys4

Sequence similaritiesi

Belongs to the IF-3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXD5 Eukaryota
COG0290 LUCA
GeneTreeiENSGT00390000014424
HOGENOMiHOG000264227
HOVERGENiHBG080563
InParanoidiQ32KZ1
KOiK02520
OMAiQTMPGIA
OrthoDBiEOG091G0GZ5
TreeFamiTF332326

Family and domain databases

Gene3Di3.10.20.80, 1 hit
3.30.110.10, 1 hit
InterProiView protein in InterPro
IPR036788 T_IF-3_C_sf
IPR036787 T_IF-3_N_sf
IPR001288 Translation_initiation_fac_3
IPR019815 Translation_initiation_fac_3_C
IPR019814 Translation_initiation_fac_3_N
PANTHERiPTHR10938 PTHR10938, 1 hit
PfamiView protein in Pfam
PF00707 IF3_C, 1 hit
PF05198 IF3_N, 1 hit
SUPFAMiSSF54364 SSF54364, 1 hit
SSF55200 SSF55200, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32KZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALFLKKLT LQTVKTENYC IRRCLGKYIL QGPAPTQQPP RPSCLIHAKA
60 70 80 90 100
FSTEDTQDEM TKKKKNETAF SSVGRKINER IIHVLDEQGN DLGHMHRANV
110 120 130 140 150
IRLMAERDLR LVKRDASAEP PQYQLLTGAQ IHQERLRLRE AERAAPKPGP
160 170 180 190 200
TLTKELTFSS NIGQHDLDTK SKQIQQWIEK KYKVQITVKK GKSADEPEDK
210 220 230 240 250
MEEMCNRIVQ TMSGIATFSS RPQPIRGGKA VMCVLRPLSK KEEAAWKAAP
260 270
DTPRRDALNG GDGKDGASGV LPQ
Length:273
Mass (Da):30,619
Last modified:December 6, 2005 - v1
Checksum:iFA50E18C558875BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109845 mRNA Translation: AAI09846.1
RefSeqiNP_001033155.1, NM_001038066.2
XP_005213827.1, XM_005213770.3
XP_005213829.1, XM_005213772.3
XP_005213830.1, XM_005213773.3
XP_015329307.1, XM_015473821.1
UniGeneiBt.30788

Genome annotation databases

EnsembliENSBTAT00000027352; ENSBTAP00000027352; ENSBTAG00000020530
GeneIDi509987
KEGGibta:509987

Similar proteinsi

Entry informationi

Entry nameiIF3M_BOVIN
AccessioniPrimary (citable) accession number: Q32KZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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