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Protein

Translation initiation factor IF-3, mitochondrial

Gene

MTIF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.By similarity

GO - Molecular functioni

  1. ribosomal small subunit binding Source: BHF-UCL
  2. translation factor activity, nucleic acid binding Source: BHF-UCL
  3. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. formation of cytoplasmic translation initiation complex Source: Ensembl
  2. mitochondrial translational initiation Source: BHF-UCL
  3. regulation of translational initiation Source: Ensembl
  4. ribosome disassembly Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiREACT_335377. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-3, mitochondrial
Short name:
IF-3(Mt)
Short name:
IF-3Mt
Short name:
IF3(mt)
Short name:
IF3mt
Gene namesi
Name:MTIF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: Reactome
  2. mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionBy similarityAdd
BLAST
Propeptidei33 – 9260Removed in mature formBy similarityPRO_0000280034Add
BLAST
Chaini93 – 273181Translation initiation factor IF-3, mitochondrialPRO_0000280035Add
BLAST

Proteomic databases

PRIDEiQ32KZ1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027352.

Structurei

3D structure databases

ProteinModelPortaliQ32KZ1.
SMRiQ32KZ1. Positions 144-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 654Poly-Lys

Sequence similaritiesi

Belongs to the IF-3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG87881.
GeneTreeiENSGT00390000014424.
HOGENOMiHOG000264227.
HOVERGENiHBG080563.
InParanoidiQ32KZ1.
KOiK02520.
OMAiQTMPGIA.
OrthoDBiEOG7DZ8KV.
TreeFamiTF332326.

Family and domain databases

Gene3Di3.10.20.80. 1 hit.
3.30.110.10. 1 hit.
InterProiIPR001288. Translation_initiation_fac_3.
IPR019815. Translation_initiation_fac_3_C.
IPR019814. Translation_initiation_fac_3_N.
[Graphical view]
PANTHERiPTHR10938. PTHR10938. 1 hit.
PfamiPF00707. IF3_C. 1 hit.
PF05198. IF3_N. 1 hit.
[Graphical view]
SUPFAMiSSF54364. SSF54364. 1 hit.
SSF55200. SSF55200. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32KZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALFLKKLT LQTVKTENYC IRRCLGKYIL QGPAPTQQPP RPSCLIHAKA
60 70 80 90 100
FSTEDTQDEM TKKKKNETAF SSVGRKINER IIHVLDEQGN DLGHMHRANV
110 120 130 140 150
IRLMAERDLR LVKRDASAEP PQYQLLTGAQ IHQERLRLRE AERAAPKPGP
160 170 180 190 200
TLTKELTFSS NIGQHDLDTK SKQIQQWIEK KYKVQITVKK GKSADEPEDK
210 220 230 240 250
MEEMCNRIVQ TMSGIATFSS RPQPIRGGKA VMCVLRPLSK KEEAAWKAAP
260 270
DTPRRDALNG GDGKDGASGV LPQ
Length:273
Mass (Da):30,619
Last modified:December 6, 2005 - v1
Checksum:iFA50E18C558875BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109845 mRNA. Translation: AAI09846.1.
RefSeqiNP_001033155.1. NM_001038066.2.
XP_005213827.1. XM_005213770.2.
XP_005213829.1. XM_005213772.2.
XP_005213830.1. XM_005213773.2.
UniGeneiBt.30788.

Genome annotation databases

EnsembliENSBTAT00000027352; ENSBTAP00000027352; ENSBTAG00000020530.
GeneIDi509987.
KEGGibta:509987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109845 mRNA. Translation: AAI09846.1.
RefSeqiNP_001033155.1. NM_001038066.2.
XP_005213827.1. XM_005213770.2.
XP_005213829.1. XM_005213772.2.
XP_005213830.1. XM_005213773.2.
UniGeneiBt.30788.

3D structure databases

ProteinModelPortaliQ32KZ1.
SMRiQ32KZ1. Positions 144-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027352.

Proteomic databases

PRIDEiQ32KZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027352; ENSBTAP00000027352; ENSBTAG00000020530.
GeneIDi509987.
KEGGibta:509987.

Organism-specific databases

CTDi219402.

Phylogenomic databases

eggNOGiNOG87881.
GeneTreeiENSGT00390000014424.
HOGENOMiHOG000264227.
HOVERGENiHBG080563.
InParanoidiQ32KZ1.
KOiK02520.
OMAiQTMPGIA.
OrthoDBiEOG7DZ8KV.
TreeFamiTF332326.

Enzyme and pathway databases

ReactomeiREACT_335377. Mitochondrial translation initiation.

Miscellaneous databases

NextBioi20869232.

Family and domain databases

Gene3Di3.10.20.80. 1 hit.
3.30.110.10. 1 hit.
InterProiIPR001288. Translation_initiation_fac_3.
IPR019815. Translation_initiation_fac_3_C.
IPR019814. Translation_initiation_fac_3_N.
[Graphical view]
PANTHERiPTHR10938. PTHR10938. 1 hit.
PfamiPF00707. IF3_C. 1 hit.
PF05198. IF3_N. 1 hit.
[Graphical view]
SUPFAMiSSF54364. SSF54364. 1 hit.
SSF55200. SSF55200. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiIF3M_BOVIN
AccessioniPrimary (citable) accession number: Q32KZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 6, 2005
Last modified: April 1, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.