Q32KZ1 (IF3M_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-3, mitochondrial
Short name=IF-3(Mt)
Short name=IF-3Mt
Short name=IF3(mt)
Short name=IF3mt

Gene names

Name:

MTIF3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins By similarity.
Subcellular location	Mitochondrion Probable.
Sequence similarities	Belongs to the IF-3 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translational initiation Inferred from direct assay PubMed 12095986. Source: HGNC ribosome disassembly Inferred from direct assay PubMed 12095986. Source: HGNC
Cellular_component	mitochondrion Inferred from direct assay PubMed 12095986. Source: HGNC
Molecular_function	ribosomal small subunit binding Inferred from direct assay PubMed 12095986. Source: HGNC translation factor activity, nucleic acid binding Inferred from direct assay PubMed 12095986. Source: HGNC translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 32	32	Mitochondrion By similarity
	Propeptide	33 – 92	60	Removed in mature form By similarity		PRO_0000280034
	Chain	93 – 273	181	Translation initiation factor IF-3, mitochondrial		PRO_0000280035
Regions
	Compositional bias	62 – 65	4	Poly-Lys

Sequences

	Sequence		Length	Mass (Da)
	Q32KZ1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: FA50E18C558875BF	FASTA	273	30,619
	10 20 30 40 50 60 MAALFLKKLT LQTVKTENYC IRRCLGKYIL QGPAPTQQPP RPSCLIHAKA FSTEDTQDEM 70 80 90 100 110 120 TKKKKNETAF SSVGRKINER IIHVLDEQGN DLGHMHRANV IRLMAERDLR LVKRDASAEP 130 140 150 160 170 180 PQYQLLTGAQ IHQERLRLRE AERAAPKPGP TLTKELTFSS NIGQHDLDTK SKQIQQWIEK 190 200 210 220 230 240 KYKVQITVKK GKSADEPEDK MEEMCNRIVQ TMSGIATFSS RPQPIRGGKA VMCVLRPLSK 250 260 270 KEEAAWKAAP DTPRRDALNG GDGKDGASGV LPQ

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC109845 mRNA. Translation: AAI09846.1.
IPI	IPI00688456.
RefSeq	NP_001033155.1. NM_001038066.2.
UniGene	Bt.30788.
3D structure databases
ProteinModelPortal	Q32KZ1.
SMR	Q32KZ1. Positions 144-245.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000027352.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000027352; ENSBTAP00000027352; ENSBTAG00000020530.
GeneID	509987.
KEGG	bta:509987.
Organism-specific databases
CTD	219402.
Phylogenomic databases
eggNOG	NOG87881.
GeneTree	ENSGT00390000014424.
HOGENOM	HOG000264227.
HOVERGEN	HBG080563.
InParanoid	Q32KZ1.
KO	K02520.
OMA	HDLDTKS.
OrthoDB	EOG498V23.
Enzyme and pathway databases
BioCyc	CATTLE:509987-MONOMER.
Family and domain databases
Gene3D	3.10.20.80. 1 hit.
InterPro	IPR001288. Translation_initiation_fac_3. IPR019815. Translation_initiation_fac_3_C. IPR019814. Translation_initiation_fac_3_N. [Graphical view]
PANTHER	PTHR10938. PTHR10938. 1 hit.
Pfam	PF00707. IF3_C. 1 hit. PF05198. IF3_N. 1 hit. [Graphical view]
SUPFAM	SSF54364. IF3. 1 hit. SSF55200. IF3. 1 hit.
PROSITE	PS00938. IF3. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20869232.

Entry information

Entry name

IF3M_BOVIN

Accession

Primary (citable) accession number: Q32KZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	December 6, 2005
Last modified:	May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program