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Protein

Ankyrin repeat and SOCS box protein 17

Gene

ASB17

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 17
Short name:
ASB-17
Gene namesi
Name:ASB17
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830601 – 295Ankyrin repeat and SOCS box protein 17Add BLAST295

Proteomic databases

PaxDbiQ32KY8.
PRIDEiQ32KY8.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007708.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati146 – 176ANKAdd BLAST31
Domaini232 – 295SOCS boxPROSITE-ProRule annotationAdd BLAST64

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat

Phylogenomic databases

eggNOGiENOG410IHXS. Eukaryota.
ENOG4111HC1. LUCA.
HOGENOMiHOG000034087.
HOVERGENiHBG050587.
InParanoidiQ32KY8.
KOiK10339.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR036770. Ankyrin_rpt-contain_sf.
IPR001496. SOCS_box.
PfamiView protein in Pfam
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00969. SOCS_box. 1 hit.
PROSITEiView protein in PROSITE
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32KY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSSKLCCK TSCPRSNIFC SLVDKVFKRP SLQSLHQWGY HCYEPRVYRT
60 70 80 90 100
LAKILRYVDL EGFDILLSDY IAFVEKSGCH LEVNFNLEFT EICVNTILYW
110 120 130 140 150
VFARKGNPDF VELLLKKTKD YVQDRSFNLA LIWRTFTPVY CPSPLSGITP
160 170 180 190 200
LLYVAQTRQS NILKILLQYG ILERENNPIN IVLTILLYPS RVRIMVDHEL
210 220 230 240 250
VDIEEDAKTC LVLCSRVLST ISIREIEMQL SLGRRPIISN WLDYIPSTRY
260 270 280 290
KDPCELLHLC RITIRAQLLT NNMLPNGIFS LLIPVCLQNY LNLES
Length:295
Mass (Da):34,253
Last modified:December 6, 2005 - v1
Checksum:iA06CEE8E3F4CAFE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109851 mRNA. Translation: AAI09852.1.
RefSeqiNP_001069898.1. NM_001076430.2.
UniGeneiBt.50682.

Genome annotation databases

GeneIDi616654.
KEGGibta:616654.

Similar proteinsi

Entry informationi

Entry nameiASB17_BOVIN
AccessioniPrimary (citable) accession number: Q32KY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 6, 2005
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families