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Protein

Nuclear transcription factor Y subunit beta

Gene

NFYB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi59 – 657By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-2426168. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit beta
Alternative name(s):
CAAT box DNA-binding protein subunit B
Nuclear transcription factor Y subunit B
Short name:
NF-YB
Gene namesi
Name:NFYB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Nuclear transcription factor Y subunit betaPRO_0000269713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki140 – 140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ32KW0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000030744.

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041024.

Structurei

3D structure databases

ProteinModelPortaliQ32KW0.
SMRiQ32KW0. Positions 57-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5252A domainAdd
BLAST
Regioni53 – 14290B domainAdd
BLAST
Regioni86 – 9712Subunit association domain (SAD)By similarityAdd
BLAST
Regioni143 – 20765C domainAdd
BLAST

Domaini

Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.

Sequence similaritiesi

Belongs to the NFYB/HAP3 subunit family.Curated

Phylogenomic databases

eggNOGiKOG0869. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00550000074689.
HOVERGENiHBG008864.
InParanoidiQ32KW0.
KOiK08065.
OMAiIAGDYIG.
OrthoDBiEOG091G0Y4D.
TreeFamiTF314521.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR003956. Transcrpt_fac_NFYB/HAP3_CS.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00685. NFYB_HAP3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32KW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMDGDSSTT DASQLGISAD YIGGSHYVIQ PHDDTEDSMN DHEDTNGSKE
60 70 80 90 100
SFREQDIYLP IANVARIMKN AIPQTGKIAK DAKECVQECV SEFISFITSE
110 120 130 140 150
ASERCHQEKR KTINGEDILF AMSTLGFDSY VEPLKLYLQK FREAMKGEKG
160 170 180 190 200
IGGAVTATDG LSEELTDEAF TNQLPAGLIT ADGQQQNVMV YTTSYQQISG

VQQIQFS
Length:207
Mass (Da):22,787
Last modified:December 6, 2005 - v1
Checksum:i1B8EF1A01A3CF972
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109900 mRNA. Translation: AAI09901.1.
RefSeqiNP_001073254.1. NM_001079786.2.
XP_005206739.1. XM_005206682.3.
XP_005206741.1. XM_005206684.3.
UniGeneiBt.63176.

Genome annotation databases

EnsembliENSBTAT00000043454; ENSBTAP00000041024; ENSBTAG00000030744.
GeneIDi614382.
KEGGibta:614382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109900 mRNA. Translation: AAI09901.1.
RefSeqiNP_001073254.1. NM_001079786.2.
XP_005206739.1. XM_005206682.3.
XP_005206741.1. XM_005206684.3.
UniGeneiBt.63176.

3D structure databases

ProteinModelPortaliQ32KW0.
SMRiQ32KW0. Positions 57-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041024.

Proteomic databases

PaxDbiQ32KW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000043454; ENSBTAP00000041024; ENSBTAG00000030744.
GeneIDi614382.
KEGGibta:614382.

Organism-specific databases

CTDi4801.

Phylogenomic databases

eggNOGiKOG0869. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00550000074689.
HOVERGENiHBG008864.
InParanoidiQ32KW0.
KOiK08065.
OMAiIAGDYIG.
OrthoDBiEOG091G0Y4D.
TreeFamiTF314521.

Enzyme and pathway databases

ReactomeiR-BTA-2426168. Activation of gene expression by SREBF (SREBP).

Gene expression databases

BgeeiENSBTAG00000030744.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR003956. Transcrpt_fac_NFYB/HAP3_CS.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00685. NFYB_HAP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFYB_BOVIN
AccessioniPrimary (citable) accession number: Q32KW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.