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Protein

Cytoplasmic dynein 2 light intermediate chain 1

Gene

DYNC2LI1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-BTA-2132295. MHC class II antigen presentation.
R-BTA-5620924. Intraflagellar transport.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 2 light intermediate chain 1
Gene namesi
Name:DYNC2LI1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Cytoplasmic dynein 2 light intermediate chain 1PRO_0000318749Add
BLAST

Proteomic databases

PaxDbiQ32KV4.

Interactioni

Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043454.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3929. Eukaryota.
ENOG410XTE5. LUCA.
GeneTreeiENSGT00390000010498.
HOGENOMiHOG000006828.
HOVERGENiHBG066237.
InParanoidiQ32KV4.
KOiK10417.
OMAiLELWKKV.
OrthoDBiEOG70CR6X.
TreeFamiTF314138.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q32KV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSETLWEIA KAEVEKRGSS ENEGDGAEIG EKSVFFIGSK NGGKTTIILR
60 70 80 90 100
CLDRDEPPKP TLALEYTYGR RTKGHNIPKD IAHFWELGGG TSLLDLISIP
110 120 130 140 150
ITSDTLRTFS IVLVLDLSKP NDLWPTMENL LQATKLNIDK VIMKLGKKNS
160 170 180 190 200
KAASEMRQKM WSNMQKDHPD RELLDPFPIP LVIIGSKYDI FQDFDSEKRK
210 220 230 240 250
VICKTLRFVA HYYGASLMFT SKSEALLLKI RGVINQLAFG INKSKSICVD
260 270 280 290 300
QNKPLFITAG LDSLSQIGPP PLPDNDIGKL HARSPMDLWK KVYEKLFPPK
310 320 330 340 350
SINTLKDVKD PAKDPQYAES EVDEMRIQKD QELEQYKRSS SKSWKQIELD

S
Length:351
Mass (Da):39,712
Last modified:December 6, 2005 - v1
Checksum:i3AF8201417BA1569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109910 mRNA. Translation: AAI09911.1.
RefSeqiNP_001033140.1. NM_001038051.2.
UniGeneiBt.10818.

Genome annotation databases

EnsembliENSBTAT00000046128; ENSBTAP00000043454; ENSBTAG00000013676.
GeneIDi507311.
KEGGibta:507311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109910 mRNA. Translation: AAI09911.1.
RefSeqiNP_001033140.1. NM_001038051.2.
UniGeneiBt.10818.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043454.

Proteomic databases

PaxDbiQ32KV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046128; ENSBTAP00000043454; ENSBTAG00000013676.
GeneIDi507311.
KEGGibta:507311.

Organism-specific databases

CTDi51626.

Phylogenomic databases

eggNOGiKOG3929. Eukaryota.
ENOG410XTE5. LUCA.
GeneTreeiENSGT00390000010498.
HOGENOMiHOG000006828.
HOVERGENiHBG066237.
InParanoidiQ32KV4.
KOiK10417.
OMAiLELWKKV.
OrthoDBiEOG70CR6X.
TreeFamiTF314138.

Enzyme and pathway databases

ReactomeiR-BTA-2132295. MHC class II antigen presentation.
R-BTA-5620924. Intraflagellar transport.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiDC2L1_BOVIN
AccessioniPrimary (citable) accession number: Q32KV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.