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Protein

[Protein ADP-ribosylarginine] hydrolase

Gene

ADPRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reverse reaction of mono-ADP-ribosylation.By similarity

Catalytic activityi

Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine.
N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
[Protein ADP-ribosylarginine] hydrolase (EC:3.2.2.19)
Short name:
ADP-ribosylarginine hydrolase
Alternative name(s):
ADP-ribose-L-arginine cleaving enzyme
Gene namesi
Name:ADPRH
Synonyms:ARH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353[Protein ADP-ribosylarginine] hydrolasePRO_0000247292Add
BLAST

Proteomic databases

PaxDbiQ32KR8.
PRIDEiQ32KR8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009391.

Structurei

3D structure databases

ProteinModelPortaliQ32KR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosylglycohydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ32KR8.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG091G0AJ4.
TreeFamiTF329417.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32KR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGALMERYV AAMVLSAAGD ALGYFNGKWE FLQNGEKIHR QLAQLGGLDA
60 70 80 90 100
IDVERWRVSD DTVMHLATAE ALLEAGKVSD LTHLYSLLAK HYQDCMGDMD
110 120 130 140 150
GRAPGGASVQ NAMLLEPDKA DGWRIPFNSH EGGCGAAMRA MCIGLRFPHS
160 170 180 190 200
SQLDSLIQVS IESGRMTHHH PTGYLGALVS ALFTAYAVNG KPPQQWGRGL
210 220 230 240 250
MEVLPEAKKY IVQSGFFVEQ NLQHWSYFQD QWEKYLKLRG IWDGKSAPTF
260 270 280 290 300
PKPFDVKERD QFYSSVSYSG WGGSSGHDAP MIAYDAILAA GDSWKELAHR
310 320 330 340 350
AFFHGGDSDS TAAIAGCWWG VMYGFKGVSP SNYEKLEYRN RLEETARALY

SLR
Length:353
Mass (Da):39,152
Last modified:December 6, 2005 - v1
Checksum:i1FE3280025C0D274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109957 mRNA. Translation: AAI09958.1.
RefSeqiNP_001033643.1. NM_001038554.1.
UniGeneiBt.97346.

Genome annotation databases

EnsembliENSBTAT00000053553; ENSBTAP00000049744; ENSBTAG00000009391.
GeneIDi525738.
KEGGibta:525738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109957 mRNA. Translation: AAI09958.1.
RefSeqiNP_001033643.1. NM_001038554.1.
UniGeneiBt.97346.

3D structure databases

ProteinModelPortaliQ32KR8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ32KR8.
PRIDEiQ32KR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000053553; ENSBTAP00000049744; ENSBTAG00000009391.
GeneIDi525738.
KEGGibta:525738.

Organism-specific databases

CTDi141.

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ32KR8.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG091G0AJ4.
TreeFamiTF329417.

Gene expression databases

BgeeiENSBTAG00000009391.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADPRH_BOVIN
AccessioniPrimary (citable) accession number: Q32KR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.