Q32KR8 (ADPRH_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
[Protein ADP-ribosylarginine] hydrolase
Short name=ADP-ribosylarginine hydrolase
EC=3.2.2.19

Alternative name(s):
ADP-ribose-L-arginine cleaving enzyme

Gene names

Name:	ADPRH
Synonyms:	ARH1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reverse reaction of mono-ADP-ribosylation By similarity.
Catalytic activity	Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + protein-L-arginine. N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + L-arginine.
Sequence similarities	Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein de-ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Molecular function	ADP-ribosylarginine hydrolase activity Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	[Protein ADP-ribosylarginine] hydrolase		PRO_0000247292

Sequences

	Sequence		Length	Mass (Da)
	Q32KR8 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 1FE3280025C0D274	FASTA	353	39,152
	10 20 30 40 50 60 MCGALMERYV AAMVLSAAGD ALGYFNGKWE FLQNGEKIHR QLAQLGGLDA IDVERWRVSD 70 80 90 100 110 120 DTVMHLATAE ALLEAGKVSD LTHLYSLLAK HYQDCMGDMD GRAPGGASVQ NAMLLEPDKA 130 140 150 160 170 180 DGWRIPFNSH EGGCGAAMRA MCIGLRFPHS SQLDSLIQVS IESGRMTHHH PTGYLGALVS 190 200 210 220 230 240 ALFTAYAVNG KPPQQWGRGL MEVLPEAKKY IVQSGFFVEQ NLQHWSYFQD QWEKYLKLRG 250 260 270 280 290 300 IWDGKSAPTF PKPFDVKERD QFYSSVSYSG WGGSSGHDAP MIAYDAILAA GDSWKELAHR 310 320 330 340 350 AFFHGGDSDS TAAIAGCWWG VMYGFKGVSP SNYEKLEYRN RLEETARALY SLR

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC109957 mRNA. Translation: AAI09958.1.
IPI	IPI00905627.
RefSeq	NP_001033643.1. NM_001038554.1.
UniGene	Bt.97346.
3D structure databases
ProteinModelPortal	Q32KR8.
ModBase	Search...
Proteomic databases
PRIDE	Q32KR8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000053553; ENSBTAP00000049744; ENSBTAG00000009391.
GeneID	525738.
KEGG	bta:525738.
Organism-specific databases
CTD	141.
Phylogenomic databases
eggNOG	maNOG16396.
GeneTree	ENSGT00530000063627.
HOVERGEN	HBG050462.
Family and domain databases
InterPro	IPR012108. ADP-ribosylarg_hydro. IPR005502. Ribosyl_crysJ1. [Graphical view]
KO	K01245.
Pfam	PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view]
PIRSF	PIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAM	SSF101478. Ribosyl_crysJ1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADPRH_BOVIN

Accession

Primary (citable) accession number: Q32KR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	December 6, 2005
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program