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Protein

[Protein ADP-ribosylarginine] hydrolase

Gene

ADPRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reverse reaction of mono-ADP-ribosylation.By similarity

Catalytic activityi

Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine.
N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Potassium; via carbonyl oxygenBy similarity1
Metal bindingi30Potassium; via carbonyl oxygenBy similarity1
Metal bindingi32Potassium; via carbonyl oxygenBy similarity1
Metal bindingi59MagnesiumBy similarity1
Metal bindingi60MagnesiumBy similarity1
Metal bindingi61MagnesiumBy similarity1
Binding sitei90ADP-D-riboseBy similarity1
Binding sitei129ADP-D-ribose; via carbonyl oxygenBy similarity1
Binding sitei135ADP-D-ribose; via amide nitrogenBy similarity1
Metal bindingi308PotassiumBy similarity1
Metal bindingi309MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 108ADP-D-riboseBy similarity3
Nucleotide bindingi168 – 170ADP-D-riboseBy similarity3
Nucleotide bindingi268 – 269ADP-D-riboseBy similarity2
Nucleotide bindingi274 – 275ADP-D-riboseBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
[Protein ADP-ribosylarginine] hydrolase (EC:3.2.2.19)
Short name:
ADP-ribosylarginine hydrolase
Alternative name(s):
ADP-ribose-L-arginine cleaving enzyme
Gene namesi
Name:ADPRH
Synonyms:ARH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472921 – 353[Protein ADP-ribosylarginine] hydrolaseAdd BLAST353

Proteomic databases

PaxDbiQ32KR8.
PRIDEiQ32KR8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009391.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049744.

Structurei

3D structure databases

ProteinModelPortaliQ32KR8.
SMRiQ32KR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosylglycohydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ32KR8.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG091G0AJ4.
TreeFamiTF329417.

Family and domain databases

Gene3Di1.10.4080.10. 1 hit.
InterProiView protein in InterPro
IPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
PfamiView protein in Pfam
PF03747. ADP_ribosyl_GH. 1 hit.
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32KR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGALMERYV AAMVLSAAGD ALGYFNGKWE FLQNGEKIHR QLAQLGGLDA
60 70 80 90 100
IDVERWRVSD DTVMHLATAE ALLEAGKVSD LTHLYSLLAK HYQDCMGDMD
110 120 130 140 150
GRAPGGASVQ NAMLLEPDKA DGWRIPFNSH EGGCGAAMRA MCIGLRFPHS
160 170 180 190 200
SQLDSLIQVS IESGRMTHHH PTGYLGALVS ALFTAYAVNG KPPQQWGRGL
210 220 230 240 250
MEVLPEAKKY IVQSGFFVEQ NLQHWSYFQD QWEKYLKLRG IWDGKSAPTF
260 270 280 290 300
PKPFDVKERD QFYSSVSYSG WGGSSGHDAP MIAYDAILAA GDSWKELAHR
310 320 330 340 350
AFFHGGDSDS TAAIAGCWWG VMYGFKGVSP SNYEKLEYRN RLEETARALY

SLR
Length:353
Mass (Da):39,152
Last modified:December 6, 2005 - v1
Checksum:i1FE3280025C0D274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109957 mRNA. Translation: AAI09958.1.
RefSeqiNP_001033643.1. NM_001038554.1.
UniGeneiBt.97346.

Genome annotation databases

EnsembliENSBTAT00000053553; ENSBTAP00000049744; ENSBTAG00000009391.
GeneIDi525738.
KEGGibta:525738.

Similar proteinsi

Entry informationi

Entry nameiADPRH_BOVIN
AccessioniPrimary (citable) accession number: Q32KR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 6, 2005
Last modified: September 27, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families